ID A0A2I3TTN5_PANTR Unreviewed; 494 AA.
AC A0A2I3TTN5; A0A2J8QL02;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Cochlin {ECO:0000256|ARBA:ARBA00013828};
GN Name=COCH {ECO:0000313|Ensembl:ENSPTRP00000092581.1,
GN ECO:0000313|VGNC:VGNC:12614};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000092581.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000092581.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000092581.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in the control of cell shape and motility in the
CC trabecular meshwork. {ECO:0000256|ARBA:ARBA00003388}.
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DR EMBL; AACZ04059444; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04059445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3TTN5; -.
DR SMR; A0A2I3TTN5; -.
DR Ensembl; ENSPTRT00000080490.1; ENSPTRP00000092581.1; ENSPTRG00000006237.6.
DR VGNC; VGNC:12614; COCH.
DR GeneTree; ENSGT00940000159386; -.
DR Proteomes; UP000002277; Chromosome 14.
DR Bgee; ENSPTRG00000006237; Expressed in pituitary gland and 16 other cell types or tissues.
DR CDD; cd01472; vWA_collagen; 1.
DR CDD; cd01482; vWA_collagen_alphaI-XII-like; 1.
DR Gene3D; 2.170.130.20; LCCL-like domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR InterPro; IPR004043; LCCL.
DR InterPro; IPR036609; LCCL_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020:SF36; COCHLIN; 1.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR Pfam; PF03815; LCCL; 1.
DR Pfam; PF00092; VWA; 2.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00603; LCCL; 1.
DR SMART; SM00327; VWA; 2.
DR SUPFAM; SSF69848; LCCL domain; 1.
DR SUPFAM; SSF53300; vWA-like; 2.
DR PROSITE; PS50820; LCCL; 1.
DR PROSITE; PS50234; VWFA; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..494
FT /note="Cochlin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015082105"
FT DOMAIN 28..121
FT /note="LCCL"
FT /evidence="ECO:0000259|PROSITE:PS50820"
FT DOMAIN 165..350
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 367..494
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 128..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 494 AA; 53230 MW; 9920EEF97A0AF2FF CRC64;
MSAAWIPALG LGVCLLLLPG PAGSEGAAPI AITCFTRGLD IRKEKADVLC PGGCPLEEFS
VYGNIVYASV SSICGAAVHR GVISNSGGPV RVYSLPGREN YSSVDANGIQ SQMLSRWSAS
FTVTKGKSST QEATGQAVST AHPPTGKRLK KTPEKKTGNK DCKADIAFLI DGSFNIGQRR
FNLQKNFVGK VALMLGIGTE GPHVGLVQAS EHPKIEFYLK NFTSAKDVLF AIKEVGFRGG
NSNTGKALKH TAQKFFTVDA GVRKGIPKVV VVFIDGWPSD DIEEAGIVAR EFGVNVFIVS
VAKPIPEELG MVQDVTFVDK AVCRNNGFFS YHMPNWFGTT KYVKPLVQKL CTHEQMMCSK
TCYNSVNIAF LIDGSSSVGD SNFRLMLEFV SNIAKTFEIS DIGAKIAAVQ FTYDQRTEFS
FTDYSTKENV LAVIRNIRYM SGGTATGDAI SFTVRNVFGP IRESPNKNFL VIVTDGQSYD
DVQGPAAAAH DAAK
//
