ID A0A2I3TV33_PANTR Unreviewed; 450 AA.
AC A0A2I3TV33;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Prune exopolyphosphatase 1 {ECO:0000313|Ensembl:ENSPTRP00000093038.1};
GN Name=PRUNE1 {ECO:0000313|Ensembl:ENSPTRP00000093038.1,
GN ECO:0000313|VGNC:VGNC:57603};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000093038.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000093038.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000093038.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the PPase class C family. Prune subfamily.
CC {ECO:0000256|ARBA:ARBA00010331}.
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DR EMBL; AACZ04025302; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I3TV33; -.
DR Ensembl; ENSPTRT00000079422.1; ENSPTRP00000093038.1; ENSPTRG00000050821.1.
DR VGNC; VGNC:57603; PRUNE1.
DR GeneTree; ENSGT00450000040262; -.
DR Proteomes; UP000002277; Chromosome 1.
DR Bgee; ENSPTRG00000050821; Expressed in hindlimb stylopod muscle and 21 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016462; F:pyrophosphatase activity; IEA:InterPro.
DR Gene3D; 3.10.310.20; DHHA2 domain; 1.
DR Gene3D; 3.90.1640.10; inorganic pyrophosphatase (n-terminal core); 1.
DR InterPro; IPR001667; DDH_dom.
DR InterPro; IPR038763; DHH_sf.
DR InterPro; IPR004097; DHHA2.
DR InterPro; IPR038222; DHHA2_dom_sf.
DR PANTHER; PTHR12112; BNIP - RELATED; 1.
DR PANTHER; PTHR12112:SF47; EXOPOLYPHOSPHATASE PRUNE1; 1.
DR Pfam; PF01368; DHH; 1.
DR Pfam; PF02833; DHHA2; 1.
DR SMART; SM01131; DHHA2; 1.
DR SUPFAM; SSF64182; DHH phosphoesterases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 212..356
FT /note="DHHA2"
FT /evidence="ECO:0000259|SMART:SM01131"
FT REGION 392..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 450 AA; 49852 MW; 936B925FEC3E9C35 CRC64;
SEFPIFLSLQ ESRPLHVVLG NEACDLDSTV SALALAFYLA KTTEAEEVFV PVLNIKRSEL
PLRGDIVFFL QKVHIPESIL IFRDEIDLHA LYQAGQLTLI LVDHHILSKS DTALEEAVAE
VLDHRPIEPK HCPPCHVSVE LVGSCATLVT ERILQGAPEI LDRQTAALLH GTIILDCVNM
DLKIGKATPK DSKYVEKLEV LFPDLPKRND IFGSLQKAKF DVSGLTTEQM LRKDQKTIYR
QGVKVAISAI YMDLEAFLQR SNLLADLHAF CQAHSYDVLV AMTIFFNTHN EPVRQLAIFC
PHVALQTTIC EVLERSHSPP LKLTPASSTH PNLHAYLQGN TQVSRKKLLP LLQEALSAYF
DSMKIPSGQP ETADVSREQV DKELDRASNS LISGLSQDEE DPPLPPTPMN SLVDECPLDQ
GLPKLSAEAV FEKCSQISLS QSTTASLSKK
//
