ID A0A2I3TV86_PANTR Unreviewed; 1412 AA.
AC A0A2I3TV86; A0A2J8LPL7;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Zinc finger protein 462 {ECO:0000313|Ensembl:ENSPTRP00000093149.1};
GN Name=ZNF462 {ECO:0000313|Ensembl:ENSPTRP00000093149.1,
GN ECO:0000313|VGNC:VGNC:4907};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000093149.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000093149.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000093149.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AACZ04023136; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPTRT00000080664.1; ENSPTRP00000093149.1; ENSPTRG00000021228.5.
DR VGNC; VGNC:4907; ZNF462.
DR GeneTree; ENSGT00940000156411; -.
DR OMA; MHYNDCH; -.
DR Proteomes; UP000002277; Chromosome 9.
DR Bgee; ENSPTRG00000021228; Expressed in skeletal muscle tissue and 20 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 7.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24403:SF67; ENHANCER OF VARIEGATION 3-9-RELATED; 1.
DR PANTHER; PTHR24403; ZINC FINGER PROTEIN; 1.
DR SMART; SM00355; ZnF_C2H2; 23.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 315..343
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 737..764
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 897..919
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 931..959
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 960..988
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1206..1233
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1234..1262
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1320..1342
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1028..1058
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1277..1302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1412 AA; 161469 MW; 7A740A50DE97F29E CRC64;
MMRGVEGPQG SPRPPAPIQQ LNRSSSERDG PPVENEMFFC QHCDYGNRTV KGVLIHYQKK
HRDFKANADV IRQHTATIRS LCDRNQKKPA SCVLVSPSNL ERDKTKLRAL KCRQCSYTSP
YFYALRKHIK KDHPALKATV TSIMRWAFLD GLIEAGYHCE WCIYSHTEPN GLLLHYQRRH
PEHYVDYTYM ATKLWAGPDP SPPSLTMPAE AKTYRCRDCV FEAVSIWDIT NHYQAFHPWA
MNGDESVLLD IIKEKDAVEK PILSSEELAG PVNCENSIPT PLPEQEAECP EDARLSPEKS
LQLASANPAI SSTPYQCTVC QSEYNNLHGL LTHYGKKHPG MKVKAADFAQ DIDINPGAVY
KCRHCPYINT RIHGVLTHYQ KRHPSIKVTA EDFVHDVEQS ADISQNDVEE TSRIFKQGYG
AYRCKLCPYT HGTLEKLKIH YEKYHNQPEF DVFSQSPPKL PVPLEPEMTT EVSPSQVSIT
EEEVGEEPVS TSHFSTSHLV SHTVFRCQLC KYFCSTRKGI ARHYRIKHNN VRAQPEGKNN
LFKCALCAYT NPIRKGLAAH YQKRHDIDAY YTHCLAASRT ISDKPNKVII PSPPKDDSPQ
LSEELRRAVE KKKCSLCSFQ SFSKKGIVSH YMKRHPGVFP KKQHASKLGG YFTAVYADEH
EKPTLMEEEE RGSFEKAEVE GEAQEIEWLP FRCIKCFKLS FSTAELLCMH YTDHHSRDLK
RDFIILGNGP RLQNSTYQCK HCDSKLQSTA ELTSHLNIHN EEFQKRAKRQ ERRKQLLSKQ
KYADGAFADF KQERPFGHLE EVPKIKERKV VGYKCKFCVE VHPTLRAICN HLRKHVQYGN
VPAVSAAVKQ EADDPAHLFL DGLEAAKDAS GALVGRVDGE HCLLDGMLED ETRPGGYHCS
QCDRVLMSMQ GLRSHERSHL ALAMFTREDK YSCQYCSFVS AFRHNLDRHM QTHHGHHKPF
RCKLCSFKSS YNSRLKTHIL KAHAGEHAYK CSWCSFSTMT ISQLKEHSLK VHGKALTLPR
PRIVSLLSSH SHHSSQKATP AEEVEDSNDS SYSEPPDVQQ QLNHYQSAAL ARNNSRVSPV
PLSGAAAGTE QKTEAVLHCE FCEFSSGYIQ SIRRHYRDKH GGKKLFKCKD CSFYTGFKSA
FTMHVEAGHS AVPEEGPKDL RCPLCLYHTK YKRNMIDHIV LHREERVVPI EVCRSKLSKY
LQGVVFRCDK CTFTCSSDES LQQHIEKHNE LKPYKCQLCY YETKHTEELD SHLRDEHKVS
RNFELVGRVN LDQLEQMKEK MESSSSDDED KEEEMNSKAE DRELMRFSDH GAALNTEKRF
PCEFCGRAFS QGSEWERHVL RHGMALNDTK QVSREEIHPK EIMENSVKMP SIEEKEDDEA
IGIDFSLKNE TVAICVVTAD KSLLENAEAK KE
//
