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Database: UniProt
Entry: A0A2I3TWE9_PANTR
LinkDB: A0A2I3TWE9_PANTR
Original site: A0A2I3TWE9_PANTR 
ID   A0A2I3TWE9_PANTR        Unreviewed;      2689 AA.
AC   A0A2I3TWE9;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   05-DEC-2018, entry version 5.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 2 {ECO:0000313|Ensembl:ENSPTRP00000093590};
GN   Name=ITPR2 {ECO:0000313|Ensembl:ENSPTRP00000093590,
GN   ECO:0000313|VGNC:VGNC:8425};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000093590, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000093590, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000093590}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
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DR   EMBL; AACZ04032292; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04032293; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04032294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04032295; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04032296; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPTRT00000093881; ENSPTRP00000093590; ENSPTRG00000004781.
DR   VGNC; VGNC:8425; ITPR2.
DR   GeneTree; ENSGT00940000156039; -.
DR   OMA; ENQVKGG; -.
DR   Proteomes; UP000002277; Chromosome 12.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2222   2246       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2258   2278       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2298   2323       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2335   2357       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2369   2396       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2417   2439       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      104    158       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      165    215       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      223    279       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      286    364       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      370    426       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       81    101       {ECO:0000256|SAM:Coils}.
FT   COILED     1918   1938       {ECO:0000256|SAM:Coils}.
FT   COILED     2634   2668       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2689 AA;  307744 MW;  13B79C54EC599C43 CRC64;
     LELIMMLHIY IHEIIKLYWA VIQLVDDRCV VHPEAGDLAN PPKKFRDCLF KVCPMNRYSA
     QKQYWKAKQA KQGNHTEAAL LKKLQHAAEL EQKQNESENK KLLGEIVKYS NVIQLLHIKS
     NKYLTVNKRL PALLEKNAMR VSLDAAGNEG SWFYIHPFWK LRSEGDNIVV GDKVVLMPVN
     AGQPLHASNI ELLDNPGCKE VNAVNCNTSW KITLFMKYSS YREDVLKGGD VVRLFHAEQE
     KFLTCDEYEK KQHIFLRTTL RQSATSATSS KALWEIEVVH HDPCRGGAGQ WNSLFRFKHL
     ATGNYLAAEL NPDYRDAQNE GKNVRDGVPP TSKKKRQAGE KIMYTLVSVP HGNDIASLFE
     LDATTLQRAD CLVPRNSYVR LRHLCTNTWV TSTSIPIDTD EERPVMLKIG TCQTKEDKEA
     FAIVSVPLSE VRDLDFANDA NKVLATTVKK LENGTITQNE RRFVTKLLED LIFFVADVPN
     NGQEVLDVVI TKPNRERQKL MREQNILAQV FGILKAPFKE KAGEGSMLRL EDLGDQRYAP
     YKYMLRLCYR VLRHSQQDYR KNQEYIAKNF CVMQSQIGYD ILAEDTITAL LHNNRKLLEK
     HITAKEIETF VSLLRRNREP RFLDYLSDLC VSNTTAIPVT QELICKFMLS PGNADILIQT
     KVVSMQADNP MESSILSDDI DDEEVWLYWI DSNKEPHGKA IRHLAQEAKE GTKADLEVLT
     YYRYQLNLFA RMCLDRQYLA INQISTQLSV DLILRCVSDE SLPFDLRASF CRLMLHMHVD
     RDPQESVVPV RYARLWTEIP TKITIHEYDS ITDSSRNDMK RKFALTMEFV EEYLKEVVNQ
     PFPFGDKEKN KLTFEVVHLA RNLIYFGFYS FSELLRLTRT LLAILDIVQA PMSSYFERLS
     KFQDGGNNVM RTIHGVGEMM TQMVLSRGSI FPMSMPDVPP SIHPSKQGSP TEHEDVTVMD
     TKLKIIEILQ FILSVRLDYR ISYMLSIYKK EFGEDNDNAE TSASGSPDTL LPSAIVPDID
     EIAAQAETMF AGRKEKNPVQ LDDEGGRTFL RVLIHLIMHD YPPLLSGALQ LLFKHFSQRA
     EVLQAFKQVQ LLVSNQDVDN YKQIKADLDQ LRLTVEKSEL WVEKSSNYEN GEIGESQVKG
     GEEPIEESNI LSPVQDGTKK PQIDSNKSNN YRIVKEILIR LSKLCVQNKK CRNQHQRLLK
     NMGAHSVVLD LLQIPYEKND EKMNEVMNLA HTFLQNFCRG NPQNQVLLHK HLSLFLTPGL
     LEAETMRHIF MNNYHLCNEI SERVVQHFVH CIETHGRHVE YLRFLQTIVK ADGKYVKKCQ
     DMVMTELING GEDVLIFYND RASFPILLHM MCSERDRGDE SGPLAYHITL VELLAACTEG
     KNVYTEIKCN SLLPLDDIVR VVTHDDCIPE VKIAYVNFVN HCYVDTEVEM KEIYTSNHIW
     KLFENFLVDM ARVCNTTTDR KHADIFLEKC VTESIMNIVS GFFNSPFSDN STSLQTHQPV
     FIQLLQSAFR IYNCTWPNPA QKASVESCIR TLAEVAKNRG IAIPVDLDSQ VNTLFMKSHS
     NMVQRAAMGW RLSARSGPRF KEALGGPAWD YRNIIEKLQD VVASLEHQFS PMMQAEFSVL
     VDVLYSPELL FPEGSDARIR CGAFMSKLIN HTKKLMEKEE KLCIKILQTL REMLEKKDSF
     VEEGNTLRKI LLNRYFKGDY SIGVNGHLSG AYSKTAQSCH SFSHFRILMI HLHMGISMSD
     IQCLLDKEGA SELVIDVIVN TKNDRIFSEG IFLGIALLEG GNTQTQYSFY QQLHEQKKSE
     KFFKVLYDRM KAAQKEIRST VTVNTIDLGN KKRDDDNELM TSGPRMRVRD STLHLKEGMK
     GQLTEASSAT SKAYCVYRRE MDPEIDIMCT GPEAGNTEEK SAEEVTMSPA IAIMQPILRF
     LQLLCENHNR ELQNFLRNQN NKTNYNLVCE TLQFLDCICG STTGGLGLLG LYINEKNVAL
     VNQTLESLTE YCQGPCHENQ TCIATHESNG IDIIIALILN DINPLGKYRM DLVLQLKNNA
     SKLLLAIMES RHDSENAERI LFNMRPRELV DVMKNAYNQG LECDHGDDEG GDDGVSPKDV
     GHNIYILAHQ LARHNKLLQQ MLKPGSDPDE GDEALKYYAK HTAQIEIVRH DRTMEQIVFP
     VPNICEYLTR ESKCRVFNTT ERDEQGSKVN DFFQQTEDLY NEMKWQKKIR NNPALFWFSR
     HISLWGSISF NLAVFINLAV ALFYPFGDDG DEGTLSPLFS VLLWIAVAIC TSMLFFFSKP
     VGIRPFLVSI MLRSIYTIGL GPTLILLGAA NLCNKIVFLV SFVGNRGTFT RGYRAVILDM
     AFLYHVAYVL VCMLGLFVHE FFYSFLVKWL AFVFVIIFLF VHLFLQCLLF LLLFDLVYRE
     ETLLNVIKSV TRNGRSIILT AVLALILVYL FSIIGFLFLK DDFTMEVDRL KNRTPVTGSH
     QVPTMTLTTM MEACAKENCS PTIPASNTAD EEYEDGIERT CDTLLMCIVT VLNQGLRNGG
     GVGDVLRRPS KDVSLVYCVV FNHNILNWHT LTERLERDKF DNKTVSFEEH IKSEHNMWHY
     LYFIVLVKVK DPTEYTGPES YVAQMIVEKN LDWFPRMRAM SLVSNEGDSE QNEIRSLQEK
     LESTMSLVKQ LSGQLAELKE QMTEQRKNKQ RLGFLGSNTP HVNHHMPPH
//
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