ID A0A2I3TXF4_PANTR Unreviewed; 358 AA.
AC A0A2I3TXF4; A0A2J8MUD4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Sodium/bile acid cotransporter {ECO:0000256|PIRNR:PIRNR026166};
GN Name=SLC10A7 {ECO:0000313|Ensembl:ENSPTRP00000093956.1,
GN ECO:0000313|VGNC:VGNC:12977};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000093956.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000093956.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000093956.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Does not show transport activity towards bile acids or
CC steroid sulfates. {ECO:0000256|PIRNR:PIRNR026166}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|PIRNR:PIRNR026166}.
CC Endoplasmic reticulum membrane {ECO:0000256|PIRNR:PIRNR026166}. Golgi
CC apparatus membrane {ECO:0000256|ARBA:ARBA00004394}.
CC -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC 2.A.28) family. {ECO:0000256|ARBA:ARBA00006528,
CC ECO:0000256|PIRNR:PIRNR026166}.
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DR EMBL; AACZ04004999; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009446668.2; XM_009448393.2.
DR RefSeq; XP_016807824.1; XM_016952335.1.
DR AlphaFoldDB; A0A2I3TXF4; -.
DR SMR; A0A2I3TXF4; -.
DR STRING; 9598.ENSPTRP00000093956; -.
DR PaxDb; 9598-ENSPTRP00000057141; -.
DR Ensembl; ENSPTRT00000096714.1; ENSPTRP00000093956.1; ENSPTRG00000016491.6.
DR GeneID; 101056859; -.
DR KEGG; ptr:101056859; -.
DR CTD; 84068; -.
DR VGNC; VGNC:12977; SLC10A7.
DR GeneTree; ENSGT00390000011932; -.
DR InParanoid; A0A2I3TXF4; -.
DR OrthoDB; 3290500at2759; -.
DR Proteomes; UP000002277; Chromosome 4.
DR Bgee; ENSPTRG00000016491; Expressed in bone marrow and 21 other cell types or tissues.
DR GO; GO:0005801; C:cis-Golgi network; IEA:Ensembl.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005797; C:Golgi medial cisterna; IEA:Ensembl.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005802; C:trans-Golgi network; IEA:Ensembl.
DR GO; GO:0015125; F:bile acid transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0060348; P:bone development; IEA:Ensembl.
DR GO; GO:0034436; P:glycoprotein transport; IEA:Ensembl.
DR GO; GO:0048193; P:Golgi vesicle transport; IEA:Ensembl.
DR GO; GO:0030210; P:heparin biosynthetic process; IEA:Ensembl.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR016833; Put_Na-Bile_cotransptr.
DR PANTHER; PTHR18640:SF5; SODIUM_BILE ACID COTRANSPORTER 7; 1.
DR PANTHER; PTHR18640; SOLUTE CARRIER FAMILY 10 MEMBER 7; 1.
DR Pfam; PF13593; SBF_like; 1.
DR PIRSF; PIRSF026166; UCP026166; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|PIRNR:PIRNR026166};
KW Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR026166};
KW Ion transport {ECO:0000256|PIRNR:PIRNR026166};
KW Membrane {ECO:0000256|PIRNR:PIRNR026166, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Sodium {ECO:0000256|PIRNR:PIRNR026166};
KW Sodium transport {ECO:0000256|PIRNR:PIRNR026166};
KW Symport {ECO:0000256|PIRNR:PIRNR026166};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|PIRNR:PIRNR026166}.
FT TRANSMEM 41..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 70..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 103..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 268..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 358 AA; 39485 MW; D23352F5F3990822 CRC64;
MRLLERMRKD WFMVGIVLAI AGAKLEPSIG VNGGPLKPEI TVSYIAVATI FFNSGLSLKT
EELTSALVHL KLHLFIQIFT LAFFPATIWL FLQLLSITPI NEWLLKGLQT VGCMPPPVSS
AVILTKAVGG NEAAAIFNSA FGSFLGIVIT PLLLLLFLGS SSSVPFTSIF SQLFMTVVVP
LIIGQIVRRY IKDWLERKKP PFGAISSSVL LMIIYTTFCD TFSNPNIDLD KFSLVLILFI
IFSIQLSFML LTFIFSTRNN SGFTPADTVA IIFCSTHKSL TLGIPMLKIV FAGHEHLSLI
SVPLLIYHPA QILLGSVLVP TIKSWMVSRQ KKLLQTRGPL ANLNNPEGLE YLSIKFGH
//
