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Database: UniProt
Entry: A0A2I4ANA0_9TELE
LinkDB: A0A2I4ANA0_9TELE
Original site: A0A2I4ANA0_9TELE 
ID   A0A2I4ANA0_9TELE        Unreviewed;       963 AA.
AC   A0A2I4ANA0;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   11-DEC-2019, entry version 12.
DE   SubName: Full=interferon-induced helicase C domain-containing protein 1 {ECO:0000313|RefSeq:XP_013856958.1};
GN   Name=ifih1 {ECO:0000313|RefSeq:XP_013856958.1};
OS   Austrofundulus limnaeus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae;
OC   Austrofundulus.
OX   NCBI_TaxID=52670 {ECO:0000313|Proteomes:UP000192220, ECO:0000313|RefSeq:XP_013856958.1};
RN   [1] {ECO:0000313|RefSeq:XP_013856958.1}
RP   IDENTIFICATION.
RC   STRAIN=Quisiro {ECO:0000313|RefSeq:XP_013856958.1};
RC   TISSUE=Liver {ECO:0000313|RefSeq:XP_013856958.1};
RG   RefSeq;
RL   Submitted (JAN-2018) to UniProtKB.
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DR   RefSeq; XP_013856958.1; XM_014001504.1.
DR   GeneID; 106512943; -.
DR   KEGG; alim:106512943; -.
DR   CTD; 64135; -.
DR   KO; K12647; -.
DR   OrthoDB; 1337630at2759; -.
DR   Proteomes; UP000192220; Genome assembly.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   Gene3D; 2.170.150.30; -; 1.
DR   InterPro; IPR001315; CARD.
DR   InterPro; IPR031964; CARD_dom.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR041204; RIG-I_C.
DR   InterPro; IPR038557; RLR_C_sf.
DR   InterPro; IPR021673; RLR_CTR.
DR   Pfam; PF16739; CARD_2; 2.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   Pfam; PF18119; RIG-I_C; 1.
DR   Pfam; PF11648; RIG-I_C-RD; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF47986; SSF47986; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50209; CARD; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51789; RLR_CTR; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000313|RefSeq:XP_013856958.1};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Helicase {ECO:0000313|RefSeq:XP_013856958.1};
KW   Hydrolase {ECO:0000313|RefSeq:XP_013856958.1};
KW   Nucleotide-binding {ECO:0000313|RefSeq:XP_013856958.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192220}.
FT   DOMAIN          110..196
FT                   /note="CARD"
FT                   /evidence="ECO:0000259|PROSITE:PS50209"
FT   DOMAIN          273..466
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          638..814
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   DOMAIN          821..951
FT                   /note="RLR CTR"
FT                   /evidence="ECO:0000259|PROSITE:PS51789"
FT   REGION          220..254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          534..554
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   963 AA;  109096 MW;  A7D646AB13F02B3D CRC64;
     MESASDEIQE RLIEGFRLRL EKNITVAPTL NHLAFIQPEE KEQIIQKLRS DGEICAARLL
     ITVVLKKPHS EGWFRAFVDG LILGGSELAA KYLELNPPSP DVEEENDYCV KLIQILAPGL
     ETMKTEEVCA ECFSSEIITE DDKEKILAET RNKGSRSGAS ELLRRIVKRP PGWFSTFLDV
     LRKTEHKHLY ELTGGSPECE PCEKSLNGEP AVETKEIRFT EEPQDDPTDL YASADMPEST
     DASNPGDLGA AAAATKSPEK AEITLWDYQM EVARPALEGK NIIICLPTGS GKTRVAVYVT
     KKHLDSRREE GKPGKVIILV NKIPLVEQHF TTEFSPYLKP KYKVERVSGD SQLKISFAKT
     VQRNDVLICT AQILENYLER ANSGEDEGVK LSDLTLIIID ECHHTQKGGV YNHIMMRYLK
     QKHKNIRRKK EEKDPIPLPQ ILGLTASPGV GKANTMDKAV EHIMRICANL DASNIMTRSL
     GEDQKKLRKI TMTAEDRKED PFGDVIKTIM NAIHDHAKFS PTCDLGSQNY EQWAVQKERQ
     AAKEENQIER VCAEYLRRYN EGLILSNTIR MCDALRCLNK FHEEQIKKKS SVDEEQNIQI
     TDTERFLFKQ FKDKKEMLEK LAKIPEYEND SLAKLKSKIL QEFSTRQEAR GIIFTKTRHS
     AITLSQWIQE NPKFADIGVK PSHVIGGGDQ SDVKPMTAAE QKDVLKKFKT GEVNLLVATT
     VAEEGLDIPA CNFVIRYGLS TNEIAMIQAQ GRGRAEDSSY TVVDVKNSGV AEKECVNEHR
     EDMMNKAIKK IKTYSSDKYN EKIDEFQIQA IMEERVRQVK QKQKAIKDES PSAVKFSCRG
     CSENICSGED INIIENMHRV NVTPQFKELF NLRENAALQE RLLDYETNGV IACKICGQTW
     GSMMMYRGIE CPCLHVKNFV VDIRGKKISN CTKWSDLPVR FSSFDYAEYA YQMAQSSDDE
     EAD
//
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