ID A0A2I4AP57_9TELE Unreviewed; 2748 AA.
AC A0A2I4AP57;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 10-FEB-2021, entry version 8.
DE SubName: Full=centromere protein F isoform X2 {ECO:0000313|RefSeq:XP_013857265.1};
GN Name=cenpf {ECO:0000313|RefSeq:XP_013857265.1};
OS Austrofundulus limnaeus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae;
OC Austrofundulus.
OX NCBI_TaxID=52670 {ECO:0000313|Proteomes:UP000192220, ECO:0000313|RefSeq:XP_013857265.1};
RN [1] {ECO:0000313|RefSeq:XP_013857265.1}
RP IDENTIFICATION.
RC STRAIN=Quisiro {ECO:0000313|RefSeq:XP_013857265.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_013857265.1};
RG RefSeq;
RL Submitted (OCT-2020) to UniProtKB.
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DR RefSeq; XP_013857265.1; XM_014001811.1.
DR Proteomes; UP000192220; Genome assembly.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:InterPro.
DR GO; GO:0070840; F:dynein complex binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR GO; GO:0008134; F:transcription factor binding; IEA:InterPro.
DR InterPro; IPR043513; Cenp-F.
DR InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR InterPro; IPR018463; Centromere_CenpF_N.
DR PANTHER; PTHR18874; PTHR18874; 1.
DR Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR Pfam; PF10473; CENP-F_leu_zip; 2.
DR Pfam; PF10481; CENP-F_N; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000192220}.
FT DOMAIN 1..304
FT /note="CENP-F_N"
FT /evidence="ECO:0000259|Pfam:PF10481"
FT DOMAIN 1739..1881
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 1977..2120
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2642..2686
FT /note="CENP-F_C_Rb_bdg"
FT /evidence="ECO:0000259|Pfam:PF10490"
FT REGION 50..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 122..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 319..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 545..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1429..1458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1494..1620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2087..2122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2224..2254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2275..2326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2434..2459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2476..2529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2552..2664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2677..2748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 629..663
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 678..758
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 791..843
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 854..938
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 949..1011
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1016..1043
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1065..1092
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1114..1190
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1208..1325
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1458..1485
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1624..1651
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1659..1679
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1687..1721
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1743..1777
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1785..1812
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1855..1917
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2336..2412
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 50..65
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..154
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..231
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..255
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..284
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..360
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..422
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..578
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1529..1546
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1563..1598
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2230..2246
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2275..2302
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2567..2593
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2641..2655
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2716..2748
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT UNSURE 658
FT /note="D or N"
FT /evidence="ECO:0000313|RefSeq:XP_013857265.1"
SQ SEQUENCE 2748 AA; 315584 MW; 121182CB11DACF87 CRC64;
MSWAVEEWKD GLPGKALQKI QEMEVQLDKL KKERTQKQFQ LDSLESALQK QKQKVDSERT
ETSALKRENQ SLVESCDSLE KARQKAVHDL GVKEQQVNYL EGQLNSCRKT IERLEQELKK
YKNEMDRSQL GGSSSLSSSS SELQSFTPQK TFATPAPVPT HRHQDNRLEE LQEKYNQEVE
DRKRLETELK VLQVKMLSQS SVSSVSHKDI AARQAGSSIF PWQQQDHSAR APDGTETPLK
RRGASLWESH EETPIKPGQR VSSSRTVQSP GGSSQQLEQL KTLNQELRTR VSELERNLSN
QEKEIRNQAS KLQELQTHLN QARKDLAERD RDLARAGHEL SQAADKHQQL EAKSSSLEQK
LKRVTEEMNC QRHNAESCRQ ALEQKLKDQE RNSQKELAQL QSSHQALDQQ LNQTRTKMTQ
EIQQSKKDYN VLQADLDKMS LQKAQIEKES EEQKQKLLRS EQSLQVSQNK EQDLCKKMEE
LQKEKNCVTA ELDRSSRSLA QLQEEKRNSE QVLKRTQGLL EDLKVKSEGQ AEELKRLQSK
LEQQTQVSVQ EQEHLKKTLS DAEARNDKSQ NELQKQKQEA ERLNNKLAFL EKESQELNSK
LSVSQDECEA LKQEHRALLE WKQGKETLIN QTEAVQKELT DKISSLENDV SVLSEAKDEL
QNKTLCVEGE NARLSAHIDA LKGELLNKST ELEEKEHEYE KLQLQFSEAG QKHNKDLENA
GIQLAQLEAQ VKDLESRLQR EAARAELAER TNVELQEEHR AACDLVRSKD QLLELGLAEV
SQLKESLAQS TARQEEQSAR LVEEKADLLK QCEQRVSEKT EELEHIRLQM EEVQQELLLS
KNQISSTEQF LKVQEQLGAE LQKQNNAMSQ KEEELRKLCE QTSEELRDQR SQAEEQRRQA
AVQIVEVEMQ KSELETKVQD LKKEAEILLE QISSLEEREA ANRRAAEELP VLKNDLDVAN
RSLEQLNDAL SSANETKSNL ENILAEKLKL ISALETEILD LTEKMRDESE SRRAEIHDLM
NKEKQLKEQL EMSQKSAAAA KTELSSRREE IRTMKSTIAA ASRGLEERDG AIKSLKEKLN
KSEAEQVKAS DLLKEKIAAM NKIKVQMEML QMDLEDNETA ISSADSQVDE LKKTVASLEA
ELTQNQTQMS ELEARLEESK AQVSVLEIRL DEVQSQNSLL ESKYVTAKEE LLERSCEITR
LEEDTVRRQQ VEESVALLES KVAQLEDENT KLEATLRQLV QEKDHRLNEL LQEKNHLEVS
LKQLMEDQQR ADSENLRGKE EKEELEVRVG KLTEEIKQLQ TRLDEEKLET EARIVQMSLE
RHQAETALNL IREEKSNLVV ILSGIKEEKQ QLQDKFDILA AELKQETEEK VQLECGYARV
SEENKRLEFS LSQLAEEKQQ LQASREEISS LREENECIQR SLLSSEEERQ NLKEQLETAE
RRSDEQNRDR NHQFEAEQAE LHQKLTVLQT ELTELKEQYR SLVQQVAQQH SLIQELSEPQ
DCPEGTEIHD EAEPDAGANS SPPENEQRIV SEMKPDEAES EAELKFQVEN SETGMIQNQM
EEENEACQHD VEEMRSDTEN QQVSEDDCSP RDDVLNEPEL CDSSSVQSEK KNLKPIENET
QEDFDSLKEI VSNQETELEA LRSECDLLNS ELQLRKELTA DLEVQIHNLE QKAQASEAAA
LGAAHQLSAA VEAKKSLSDE VAQLLEEKET LTLQLQTSKC QLTDVMEMLE GLEMAKGGWD
EKFLQQESEL KRVRSEKANL EQHILGMESE LETMQLQSIG LKEEMEAQKR TSSGLEQQIE
TLLTETSQLR AELVTCTEDR DELSQALCQW REKVHSLEET NGDTRSLISI LEDDIRAGRK
EYEALQSSME KLNTEKIQLL EQVKALEQVV SHLSGEKEEL LGRLDQIKED HTSANQNTES
MVGKIQALKG DVCSLSQSLE ASLLEKGEIA SRLNSTQDEV QQMRTGIEKL QVRIESDERK
KKKMGELLKA AQRKFDSLQD RLDALQREKD DVEQSLETAV LQAETARAEL EEERQKVEEE
KKELKEKLTE LSAALDNLRS VKAHLERELE AKQREIDELK AAKDELETGL EKAEVARREE
EERQNQRVDE LQRGLREEAE RRVNDLQTQL EACQQREALL SSKCAETEEE NTKMQSVLLE
LETEREKLLS SLQEWQMNGE RFRSQGEELE KDRNSLKTHI ESLQEETTAL KTLVQVKEEE
KLALEKEADQ SRASLQSISN LTAEKEQLEE TNQRLVEEKQ KLQLSLSTVE EERENMSCAL
EATKQEKDRL DQERRVLEEE KQNLQETLSS LKQAKEQTEQ EKLRVEAEKG ELLSSFSAME
EEKNNLSSAV SLLEEEKQQM KEENEKIAEE QELLQQTAEC LKKEAETHKQ TVSQLREQVS
ELTSRSARLS KERDSALSKM SLWMKTCKQL EQERMMLNSS EAKPENVQTE ELAQLMMEAE
QRKKEVEELT AALQKKRTEA EERLKETQQK DEEVEELRDA LAQKKTELEE RKKELDEANQ
LAEERSREAD ESVEKYCSLL IKVHKLEEIN EGLKIRLEQF TATRRANEAN DNRRRSSRKS
SSKRQEAEKD DNAENLVPSA AQGASPGKRG RSEVSDEGSA QEVLHNLTKK LKASXMTTPK
TRGEQEEEEF RPEGLPELVQ RGFADIPVGE ASPFIMRRTT ARRCSPRLAA RHPLPDSKVL
GSVPFQSPST DRSDXRGLSP HNKEKLSQNE SKQQVLKETT QEENCRVQ
//
