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Database: UniProt
Entry: A0A2I4AQZ7_9TELE
LinkDB: A0A2I4AQZ7_9TELE
Original site: A0A2I4AQZ7_9TELE 
ID   A0A2I4AQZ7_9TELE        Unreviewed;       851 AA.
AC   A0A2I4AQZ7;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   08-MAY-2019, entry version 8.
DE   SubName: Full=guanine nucleotide exchange factor VAV2 isoform X8 {ECO:0000313|RefSeq:XP_013857919.1};
GN   Name=vav2 {ECO:0000313|RefSeq:XP_013857919.1};
OS   Austrofundulus limnaeus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae;
OC   Austrofundulus.
OX   NCBI_TaxID=52670 {ECO:0000313|Proteomes:UP000192220, ECO:0000313|RefSeq:XP_013857919.1};
RN   [1] {ECO:0000313|RefSeq:XP_013857919.1}
RP   IDENTIFICATION.
RC   STRAIN=Quisiro {ECO:0000313|RefSeq:XP_013857919.1};
RC   TISSUE=Liver {ECO:0000313|RefSeq:XP_013857919.1};
RG   RefSeq;
RL   Submitted (JAN-2018) to UniProtKB.
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DR   RefSeq; XP_013857919.1; XM_014002465.1.
DR   GeneID; 106513570; -.
DR   CTD; 7410; -.
DR   OrthoDB; 710582at2759; -.
DR   Proteomes; UP000192220; Genome assembly.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR   CDD; cd00029; C1; 1.
DR   CDD; cd00014; CH; 1.
DR   CDD; cd01223; PH_Vav; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd10406; SH2_Vav2; 1.
DR   CDD; cd11977; SH3_VAV2_2; 1.
DR   Gene3D; 1.10.418.10; -; 1.
DR   Gene3D; 1.20.900.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR022613; CAMSAP_CH.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR037832; PH_Vav.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR035880; VAV2_SH2.
DR   InterPro; IPR035732; VAV2_SH3_2.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF11971; CAMSAP_CH; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF07653; SH3_2; 2.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00109; C1; 1.
DR   SMART; SM00033; CH; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00326; SH3; 2.
DR   SUPFAM; SSF47576; SSF47576; 1.
DR   SUPFAM; SSF48065; SSF48065; 1.
DR   SUPFAM; SSF50044; SSF50044; 2.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50021; CH; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50002; SH3; 2.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000192220};
KW   Guanine-nucleotide releasing factor {ECO:0000256|SAAS:SAAS01163629};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00253054};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192220};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW   SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192,
KW   ECO:0000256|SAAS:SAAS01042643}; Zinc {ECO:0000256|SAAS:SAAS00253075}.
FT   DOMAIN        1    119       Calponin-homology (CH).
FT                                {ECO:0000259|PROSITE:PS50021}.
FT   DOMAIN      199    377       DH. {ECO:0000259|PROSITE:PS50010}.
FT   DOMAIN      407    514       PH. {ECO:0000259|PROSITE:PS50003}.
FT   DOMAIN      525    574       Phorbol-ester/DAG-type.
FT                                {ECO:0000259|PROSITE:PS50081}.
FT   DOMAIN      586    652       SH3. {ECO:0000259|PROSITE:PS50002}.
FT   DOMAIN      675    769       SH2. {ECO:0000259|PROSITE:PS50001}.
FT   DOMAIN      789    850       SH3. {ECO:0000259|PROSITE:PS50002}.
FT   COILED      291    311       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   851 AA;  99108 MW;  57C17793D60E721D CRC64;
     MEEWRQCGRW LIDCKVLPAN HRVVWPTSGV FDLAQALRDG VLLCQMLHNL SPGSVDLKEI
     NFRPQMSQFL CLKNIRTFLK VCHDKFGLRN CELFDPFDLF DVRDFGKVIS ALSRISHHSI
     AQIKGIRPFP SEDTALNEDD VYRSLEELAD EHDLGEDDIY DCVPCDDDGD DIYEDIIKVE
     VRQPMIRYMQ KMGMTEDDKR NCCLVEIQQT EAKYYKTLED IEKNYMIPLK QVFSPQEMEA
     IFVNFEDIIR VHFALLRAID LNMASGGSGL GKIFLDFKER LLIYGQYCSH MENAQKTLEE
     LLLTREDIKI KVEECTMKVQ EGKFKLQDLL VVPMQRVLKY HLLLKDLLSY STDRPERQQL
     KEALEAMQDL AMYINEVKRD NETLKKISEF QSSIENLQQV KLEEYGRPKI DGELKVSSIV
     NRTKQDRYIF LFDKVVIVCK RKGYSYELKE IIELQSYKMS DDPMNNRDMK KSSGKMWSYG
     FYLIHLQGKQ GFQFFCKTEE TKRKWMEQFE MAMSNIKPER ATANQHNFQM HTFDKNTNCR
     SCKMLLRGIF YQGYYCTRCG TGAHKECLER ITTCKINPLD MEPGLSPGPK MVAVRNYHGT
     PIPSGKTPLC FQTGDVIELL KGDPDTPWWE GKLMQTQKSG FFPSSCVKPC LDPKPFQSLT
     SRQSSRETDY FGYPWFAGNM ERQQADNLLK SHCSGTYLIR ERTAEAERFA ISIKFNDEVK
     HIKVTEKDSW IHITEAKKFE SLLELVEYYQ SHSLKESFKL LDTTLRYPYK TRERLLSRTS
     TRSPVFTPRV VSTAVARYNF AARDMRELSL REGDIVKIYS KIGGDQGWWK GEANGRIGWF
     PSTYVDEEGV Q
//
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