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Database: UniProt
Entry: A0A2I4ASY3_9TELE
LinkDB: A0A2I4ASY3_9TELE
Original site: A0A2I4ASY3_9TELE 
ID   A0A2I4ASY3_9TELE        Unreviewed;      5068 AA.
AC   A0A2I4ASY3;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   16-JAN-2019, entry version 4.
DE   SubName: Full=LOW QUALITY PROTEIN: ryanodine receptor 1-like {ECO:0000313|RefSeq:XP_013858586.1};
GN   Name=LOC106514048 {ECO:0000313|RefSeq:XP_013858586.1};
OS   Austrofundulus limnaeus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae;
OC   Austrofundulus.
OX   NCBI_TaxID=52670 {ECO:0000313|Proteomes:UP000192220, ECO:0000313|RefSeq:XP_013858586.1};
RN   [1] {ECO:0000313|RefSeq:XP_013858586.1}
RP   IDENTIFICATION.
RC   STRAIN=Quisiro {ECO:0000313|RefSeq:XP_013858586.1};
RC   TISSUE=Liver {ECO:0000313|RefSeq:XP_013858586.1};
RG   RefSeq;
RL   Submitted (JAN-2018) to UniProtKB.
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DR   RefSeq; XP_013858586.1; XM_014003132.1.
DR   GeneID; 106514048; -.
DR   OrthoDB; 5161at2759; -.
DR   Proteomes; UP000192220; Genome assembly.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000192220};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_013858586.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192220};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4353   4376       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4583   4603       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4673   4694       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4811   4832       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4870   4890       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4949   4972       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      103    158       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      165    210       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      218    273       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      279    336       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      344    401       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      604    803       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1019   1215       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1353   1563       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     1883   1904       {ECO:0000256|SAM:Coils}.
FT   COILED     3696   3716       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5068 AA;  574768 MW;  38B1BEFCC269EB7E CRC64;
     MAEGADGEEE IQFLRTDDQV VLQCTASILK EQIKLCLSCE GFGNRLCFLE TTSNAQNVPP
     DLAICCFILE QSLSVRALQE MLSNSSVDEA VDLDKWSSQG GGSRTLLYGH AILLKHTHSN
     MYLSCLTTSR SLTDKLAFDV GLQEDSTGEA CWWTIHPASK QRSEGEKVRV GDDLILVSAS
     SERYLHLSYA SGDLMVDASF MQTLWTMTPV MSGCELAEGF LTGGYVLRLF HGHMDECLAI
     PGADQGDDQR RVAHYEGGAV CSHARSLWRL EPLRIAWSGG HIKWGQSFRV RHITTGRYLF
     LDEEKGLLLV DPEKANSKMS AFCFRISKEK IEVTQKRDVE GMGTPEIKYG ESMCFVQHVS
     SGLWLTYAAV DAKSARLGPL KRKAILHKEG HMDDALTVAR SQTEESQAAR MIYSTTGLFN
     QFIKGLDALS GKNKSTNPPS LPMDTVVLSL QDLIFYFRPP EEELEHEDKQ FKLRSLKNRQ
     NLFQEEGMIT LVLDCIDRLN VYNTAAHFSE YAGEEAAESW KEIVNLLYEL LASLIRGNRA
     NCALFCENLD WLVSKLDRLE ASSGILEVLY CVLIESPEVL NIIQENHIKS IISLLDKHGR
     NHKVLDVLCS LCVCNGVAVR SNQNLITENL LPGRDLLLQT NIINYVTSMR PNIFLGTCEG
     STQYKKWYFE VMVDHVEPFL TAQPYHLRVG WALTEGYSPY PGGGEGWGCN GVGDDLYSYG
     FDGLFLWSGR VPRHVASSSQ HALAAEDVVS CCLDLSVPSI SFRINGHPVQ GMFENFNLDG
     LFFPVVSFSA GVKLRFLLGG RHGDFKFLPP PGYAPCYEAV LPRDRLRIEF IKEYKQDFNE
     VRNLLGPTQS LSHTAFTPCP VDTIQIVLPP HLERIREKLA ENSHELWAVT RIEQGWTYGP
     LRDDNKKMHP CLVDFQSLPE PEKNYNLAMS GETLKTLLAL GCHVGMGDEK AEENLKRTKL
     PKTYMQTNGY KPAPLDLNHV KLTPNQNTLV ERLAENGHNV WARDRVRQGW TYSIVQDIMN
     KRNPRLVPYN LLDEKTKKTN RDTVCAAVRT LIGYGYNIEP PDQESSGHGT GSSRDNKIRV
     FRAEKSYAVT QGKWYFEFEA VTVGEMRVGW ARPSVRADTE LGADELAYVF NGFKAQRWHV
     GTEPFGRQWQ SGDVVGCMID LTEMNIMFTL NGEMLISDSG SEMAFKDIEI GEGFIPVCSL
     GLSQIGRINL GQNVSSLRYF TICGLQEGFE PFAXNMKREI TMWFSKSLPQ FKIVPTDHPH
     IEISRVDGTV DTPPCLKVSH KTFGSQNANT DLLFFRLSIP IEFHETFKVP AGTTLLTRAL
     TIPEDELLEV DPNSEFEILK KSASRKEQEE EKKEPSVPKE ASGVKNGENE KDASTEKSKK
     KGFLFKAKKA ALITPPPVVP TLPRLVEDVV PDDRDEMDII LNTTTYYYSV RIFAGQEPAG
     VWVGWVTPDY HQYDLHYDLS KVRTVTVTVG DDKGNIQDSI KRSNCYMVWG GEFGGSQQTR
     VSQEDFVIGC LVDLDTGLMT FTANGKEINT FYQVETNTKL FPAVFVLPSN QNVIQFELGK
     LKNIMPLSAA MFRRERKNTV PQCPPRLDVQ MLTPVIWSRM PNNFLAPETG RISERLGWMV
     QCMEPLTMMA LHIPEENRCI DILELSERMD LLKFHYHTLK LYGSVCALGN NRVAHALCSH
     VDESQLFYAI ESTYLPGPMR SGFYDLLISM HLESAKRNRL GTNKEFIVPM TNETRSITLY
     TAKSHALPGV GLTTCLRPKL HFSSVGFVGT DPDIYTLSPV IPLQVLKTKA LNMLIEAVQD
     GSQAMRDPVG GSVEFHFVPI LKLISTLLIM GVFDDEDVTH ILKMIEPTVF HTSKSEEPAD
     EKXSEEKEPA KAAVVKEEGV DXAEEEEDEE FEEYSFDEEE LEEEEELEET ESGLAHEEAV
     DSDLVKGEKG AEETEKETKP DPETKEEHLE QGLFQMKLPE SVKLQMCTLL QYFXDCELRH
     XVETIAAYSD KFVTQIQSNQ RQRYNDLMMA FTMSAAETAR KTREFRSPPQ EQVNMLMNFK
     NCPDDEESPV PDDVRESLLA FHNTLLTHCG VHIEEEEQEE XVDNSLRGRL RRLLEKVKKF
     RKKKVDMEPE PQEDKKPSTL QELISHTMIH WAQESFIQNP ELVRMMFSLL HRQYDGLGEL
     MRALPKAYTI NEVSIQDTMD LLECLGQIRS LLIVQMGPEE ERLIIQSIGN IMSNRVFYQH
     PNLMRALGMH ETVMEVMVNV LGGGDSKEIR FPRVVTNCCR FLCYFCRISR QNQRSMFDHL
     SYLLQNSGIG LGMRGSTPLD VAAASCIDNN ELALALQEQD LEMVVKYLAG CGLQSCPMLL
     AKGYPDIGWN PCGGEKYLDF LRFAVFVNGE SVEENANVVV RLLIRRPECF GPALRGEGGN
     GLLAAIEEAI KISEDPARDG PSVKKDRRFP MFGGEEQQEE NRVHLGNAIM SFYSALIDLL
     GRCAPEMHLI QAGKGEALRI RAILRSLVPL EDLVGVISLP VQIPCFGKDN SIIEPKMSAS
     FVPDHKAPMV LFLDRVYGID NQDFLLHVLE VGFLPDMRAA ASLDTAAFST TEMALALNRY
     LCSAVLPLIT KCAPLFAGSD HRAIMXDSML HTIYRLSRGR AFTKAQRDII EECLMALCKY
     LRPSMLQHLL RRLVFDVPIL NEYAKRPLKL LTSHXERCWK YYCLPNGWAN FGVASEEELH
     LTRKLFWGIF ESLAHKKFDA EIFKISMPCL CAIAGAIPPD YVDASYSSKT EKKASVDAEG
     NFDPKPIDTT NTIIPERLDP FINRYAEYTH DKWAFEKIQN NWSYGEVLDE NAKTHPMLRP
     YKTFSEKDKE IYRWPIKESI KAMLAWEWNI EKAREEEESE KKKAASRKIS QTAQATYDPS
     HGYSPQPIDI SHMALSRDLQ SMAEQLAENY HNTWGRKKKI ELQSKGGGTH PLLVPYDTLT
     AKEKARDREK AYELLKFLQL NGYAVTRGLK DMESEISSIE KRFAYGFLQK LLKWMEIAQE
     FIAHLEAVVS SGRVEKSPHE QEIKFFAKIL MPLINQYFKN HCLYFLSTPA KVLGSGGHSS
     NKEKEMIASI FCKMSALVRH RVSLFGKMSV SLSLFSVYFT SSXFRTVMKS GPEIVKAGLR
     SFFESAADDV EKMVENLKLG KVSKGNQQVK GVSQNINYTT IALLPVLTSL FDHIAQHLFG
     DDVILDDLQI SCYRIMCSIY SVGTVKNPHV ERQRPALGEC LAHLAAAMPV AYLEPHLNEF
     NAFSVYTTKT PRERAILGLP SEVQELCPDI PALDVLLKDI GDLAESGARY TEMPHVIEIT
     LPMLXNYLPR WWERGPENFP EMDGQLCTEV TSEHLNQLLG SIMKIVVNNL GIDEASWMKR
     LAVFSQPIVS RAKPEMLKSH FIPTMEKLKK RTSKVVAEED HLRMEGKSEG DDEDGTIRDE
     FAVLCRDLYA LYPLLIRYVD NNRARWLTCP DPDAEELFRM VGEVFIFWSK SHNFKREEQN
     FVVMNEINNM SFLTADSKSK MSKGGDTEGG GSDTERTKKK KRGDRYSVQT SLIVAALKKM
     LPIGLNMCSP ADQELINLAK IRYSLRDTDE EVREFLQNNL HLQGKVDNPS MRWQMALYKE
     MAGKAEDADA PVKVVKRVQE VSAVLYHLEV TEHPFKSKKM VWHKLLSKQR RRAVVACFRM
     TPLYNIARHR ASKMFLEGYK RNWIQTEGYS FEDRMIDDLS KAMEQEEAEE EEERETKPDP
     LHQLILHFSR TALTEKSKLD TDHLYMAYAD IMAKSCHMGE EEEGGDENAE DEMSFEVRQS
     ELEKEMEKQR LLXQQSRLHN RGAAEMVLQM ISACKGETGP MVSTTLKLGI SILNGGNSEV
     QRKMLEYLKD KKDVGFFLSV QALMQTCCVL DLNAFERQNK AEGLGMVSEE GTNEKVMADD
     EFTCDLFRFL QLLCEGHNND FQNYLRTQTG STTSINVIIC TVDYLLRLQE SISDFYWYYS
     GKDIIDDPGK KNFSKAMTVA KQIFNSLTEY IQGPCTGNQQ SLAHSRLWDA IVGFLHVFAH
     MMMKLAQDSS QIGLLKELLD LQKDMVVMLL SLLEGNIVNG TIARQMVDML VESSSNVEMI
     LKFFDMFLKL KDIVASDAFR DYITDPRGLI SKKDFQKAMD SQKQYAPSEI QFLLSCSEAD
     ENDMIHYEEF AGRFQEPAKD IGFNIAVLLT NLSEHVPHDS RLQNFLEQAE SVLNYFRPFL
     GRIEIMGASR RIERIYFEIS EVNRRQWEMP QVRESKRQFI FDVVNEGGES EKMEMFVNFC
     EDTIFEMNIA SKISEQEEEE KGEEDDEGDE GGGEGGQGGA AGSTGDEEGN GEGGQPESTS
     AFADFLHSMS SFLSIFTFRN LRRQYRRVRR MTFKEIIVAL SIFFWTILMS ILHFIYNVCK
     GFFVIIWQAL FGGGLVEGAK NITVTEILAS MPDPTQDDVH GDGPGETGTG EEQDAGGLTD
     TGETGSGEEE EEDTQENEGR IPGMDAPGGL GDMGIEEPVE PPTPEGTPIA KRKMAPEESD
     ASQKPPEPAP VEETPPQPEK SDAESGEKSE KEPKSREEQQ PQQLKKCPPK KEKKQKKEGG
     FQIWTELETQ RNKFMNYLSR NFYNLRFLAL FLAFALNFIL LFYKVSDTPP EGEEMEGSGL
     SEGSELFEGS GLFEGSGEDF EGSGLNGGGD EDEEEVLLYY YLEESTGYMQ PTLAFLAILH
     TVISFICIIG YNCLKIPLVI FKREKELARK LEFDGLYITE QPEDDDIKGQ WDRLVLNTPS
     FPNNYWDKFV KRKVLDKYGD IYGRERIAEL LGVDLASLDV SQQHEKKQEE PDNSVFAWLT
     SIDIKYQIWK FGVVFTDGTF LYLCWYLVMS LLGHYNNFFF ACHLLDIAMG VKTLRTILSS
     VTHNGKQLMM TVGLLAVVVY LYTVVAFNFF RKFYNKSEDE DEPDMKCDDM MTCYLFHMYV
     GVRAGGGIGD EIEDPAGDEY ELYRVVFDIT FFFFVIVILL AIIQGLIIDA FGELRDQQEQ
     VKEDMETKCF ICGIGSDYFD TTPHGFETHT FDEHNLANYM FFLMYLINKD ETEHTGQESY
     VWKMYQERCW DFFPAGDCFR KQYEDQLS
//
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