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Database: UniProt
Entry: A0A2I4AVG2_9TELE
LinkDB: A0A2I4AVG2_9TELE
Original site: A0A2I4AVG2_9TELE 
ID   A0A2I4AVG2_9TELE        Unreviewed;       377 AA.
AC   A0A2I4AVG2;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   13-NOV-2019, entry version 11.
DE   SubName: Full=ATP-sensitive inward rectifier potassium channel 1 {ECO:0000313|RefSeq:XP_013859471.1};
GN   Name=kcnj1 {ECO:0000313|RefSeq:XP_013859471.1};
OS   Austrofundulus limnaeus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae;
OC   Austrofundulus.
OX   NCBI_TaxID=52670 {ECO:0000313|Proteomes:UP000192220, ECO:0000313|RefSeq:XP_013859471.1};
RN   [1] {ECO:0000313|RefSeq:XP_013859471.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JAN-2018) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   RefSeq; XP_013859471.1; XM_014004017.1.
DR   GeneID; 106514637; -.
DR   KEGG; alim:106514637; -.
DR   CTD; 3758; -.
DR   KO; K04995; -.
DR   OrthoDB; 956263at2759; -.
DR   Proteomes; UP000192220; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003268; K_chnl_inward-rec_Kir1.1.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF6; PTHR11767:SF6; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000192220};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609, ECO:0000313|RefSeq:XP_013859471.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192220};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     58     81       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    133    159       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       22    164       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      171    337       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   SITE        150    150       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   377 AA;  42966 MW;  B2A266C10875FDD7 CRC64;
     MFQLLPGRMH PTGKQSQKTR LVTKDGHCNI EFGNIEYTXH FAYLVDFWTT FIEIRWRFVL
     LWFVVMFIGS WFIFSLLWYW IAKSNGDLRG QNHTVGHVRC IENVTGLTTA FLYSLETQTT
     IGYGGRVLTE QCAVAVILLV FQCLVGIIIN CFICGVILAK ISLPKKRAKT VTFSHTAVIC
     LKKESLCLLI QVANLRKTLL IGSQIYGKLL RMTTTPDGDT IILDQVDVDF MVDAGKDNLF
     FICPLTLYHV IDRGSPFYEL TADTLSQQDF ELVVFLDGTA ESTSSSCQVR TSYIPQEIQW
     GYSFLPIVSR TKIGKYHVDF ANFSRSVPVS TPHCIHCFEM GTDQRNHNDH RDQEKMGIDN
     LGFQVIDIHE TQDITKM
//
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