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Database: UniProt
Entry: A0A2I4BKN5_9TELE
LinkDB: A0A2I4BKN5_9TELE
Original site: A0A2I4BKN5_9TELE 
ID   A0A2I4BKN5_9TELE        Unreviewed;       548 AA.
AC   A0A2I4BKN5;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   16-OCT-2019, entry version 13.
DE   SubName: Full=inward rectifier potassium channel 4 {ECO:0000313|RefSeq:XP_013868302.1};
GN   Name=kcnj4 {ECO:0000313|RefSeq:XP_013868302.1};
OS   Austrofundulus limnaeus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae;
OC   Austrofundulus.
OX   NCBI_TaxID=52670 {ECO:0000313|Proteomes:UP000192220, ECO:0000313|RefSeq:XP_013868302.1};
RN   [1] {ECO:0000313|RefSeq:XP_013868302.1}
RP   IDENTIFICATION.
RC   STRAIN=Quisiro {ECO:0000313|RefSeq:XP_013868302.1};
RC   TISSUE=Liver {ECO:0000313|RefSeq:XP_013868302.1};
RG   RefSeq;
RL   Submitted (JAN-2018) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   RefSeq; XP_013868302.1; XM_014012848.1.
DR   GeneID; 106520642; -.
DR   KEGG; alim:106520642; -.
DR   CTD; 3761; -.
DR   OrthoDB; 956263at2759; -.
DR   Proteomes; UP000192220; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003273; K_chnl_inward-rec_Kir2.3.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF53; PTHR11767:SF53; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000192220};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609, ECO:0000313|RefSeq:XP_013868302.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192220};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM    142    165       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    225    250       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      107    255       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      262    433       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION       61     88       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   548 AA;  62678 MW;  01FD41FAECB1F660 CRC64;
     MKGEQQTEDI LYVIHLMTNN TCELRKRYSI VSDIISEDEL EKTSSVELYN GHRSTKIKKQ
     YNVEREDGRR RPGASAAAPN SXGPRAMNNY NEKILTRGSN QIRSRFVKKN GQCNVVFTNM
     EDRRQRYIAD IFTTCVDIRW RYLLLLFSAS FIISWLIFGL IFYVVSLAHG DFEEPPTQKA
     EVGGQTQRMP CILHLQGFVG AFLFSMETQT TIGYGWRCVT EECPIAVVTV VIQSILGCIL
     DSFMIGTILA KMARPKKRNQ TLMFSRNAVI TLRDGKLCLM WRVGNLRRSH IVEAHVRAQL
     VRSYVTAEGE FIPLEQMDLN VGYDNGTDRL LLVSPLVIVH KIDEDSPLYS LSRADLEADD
     FEIIVILEGM VEATAMTTQF RSSYLAREIF WGHRFEPVIY EDRNRYKVDY ACFHNTYEVP
     STPHLSAKEL DEAVSRASSV ASPISARRSA QNPIQQALTE FCYENEVALS CEDEDDVFDS
     TLALRKDRAD ERRTSVDFQN MFHDTTTITS GSHNFVCVLD MDNNQMEFDI LQKAIPLDPV
     TYKTEQEN
//
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