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Database: UniProt
Entry: A0A2I4C6N9_9TELE
LinkDB: A0A2I4C6N9_9TELE
Original site: A0A2I4C6N9_9TELE 
ID   A0A2I4C6N9_9TELE        Unreviewed;       548 AA.
AC   A0A2I4C6N9;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   08-MAY-2019, entry version 8.
DE   RecName: Full=Receptor protein serine/threonine kinase {ECO:0000256|SAAS:SAAS00138132};
DE            EC=2.7.11.30 {ECO:0000256|SAAS:SAAS00138132};
GN   Name=bmpr1a {ECO:0000313|RefSeq:XP_013875624.1};
OS   Austrofundulus limnaeus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae;
OC   Austrofundulus.
OX   NCBI_TaxID=52670 {ECO:0000313|Proteomes:UP000192220, ECO:0000313|RefSeq:XP_013875624.1};
RN   [1] {ECO:0000313|RefSeq:XP_013875624.1}
RP   IDENTIFICATION.
RC   STRAIN=Quisiro {ECO:0000313|RefSeq:XP_013875624.1};
RC   TISSUE=Liver {ECO:0000313|RefSeq:XP_013875624.1};
RG   RefSeq;
RL   Submitted (JAN-2018) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[receptor-protein]-L-serine + ATP = [receptor-protein]-O-
CC         phospho-L-serine + ADP + H(+); Xref=Rhea:RHEA:18673, Rhea:RHEA-
CC         COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421,
CC         ChEBI:CHEBI:456216; EC=2.7.11.30;
CC         Evidence={ECO:0000256|SAAS:SAAS01128400};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[receptor-protein]-L-threonine + ATP = [receptor-
CC         protein]-O-phospho-L-threonine + ADP + H(+);
CC         Xref=Rhea:RHEA:44880, Rhea:RHEA-COMP:11024, Rhea:RHEA-
CC         COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.30; Evidence={ECO:0000256|SAAS:SAAS01128404};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. TGFB receptor subfamily.
CC       {ECO:0000256|SAAS:SAAS00595019}.
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DR   RefSeq; XP_013875624.1; XM_014020170.1.
DR   GeneID; 106525825; -.
DR   CTD; 657; -.
DR   OrthoDB; 776697at2759; -.
DR   Proteomes; UP000192220; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; IEA:InterPro.
DR   InterPro; IPR000472; Activin_recp.
DR   InterPro; IPR003605; GS_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR000333; TGFB_receptor.
DR   PANTHER; PTHR23255; PTHR23255; 1.
DR   Pfam; PF01064; Activin_recp; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF08515; TGF_beta_GS; 1.
DR   SMART; SM00467; GS; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS51256; GS; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00138218};
KW   Complete proteome {ECO:0000313|Proteomes:UP000192220};
KW   Kinase {ECO:0000256|SAAS:SAAS00138139};
KW   Membrane {ECO:0000256|SAAS:SAAS00138203, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00138212};
KW   Receptor {ECO:0000256|SAAS:SAAS00138179,
KW   ECO:0000313|RefSeq:XP_013875624.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192220};
KW   Serine/threonine-protein kinase {ECO:0000256|SAAS:SAAS00138186};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|SAAS:SAAS00138167};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00138220,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00488859,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    548       Receptor protein serine/threonine kinase.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014125775.
FT   TRANSMEM    172    195       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      220    249       GS. {ECO:0000259|PROSITE:PS51256}.
FT   DOMAIN      250    541       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
SQ   SEQUENCE   548 AA;  61106 MW;  33145FCCEC1A6953 CRC64;
     MAGLSCLALI FAALLLPLRT DAAGQNPDHV LLGEGGKPEA RRPGEDSTIA PEDLPRFLSC
     YCSGHCPDDA TNNTCQTNGQ CFAIIEEDEH GDVLLTSGCM KYEGSHFQCK DSPNAQSRRT
     IECCNTDFCN GDLRPTLPPQ IPMGKLSAGV GAASRVQLTS VLLVPAESSS HWLAFLISMT
     VCCCTLICVT IVFYYKYKWQ TERDRYPKDV EQEVFIRGGE SLKDLIHQSQ SSGSGSGLPL
     LVQRTIAKQI QMVRQIGKGR YGEVWLGRWR GEKVAVKVFF TREEASWFRE TEIYQTVLMR
     HENILGFIAA DIKGSGASTQ LFLITDHHES GSLYDHLKLN TLDAQALLRL AYSAACGLCH
     LHTEIYGTQG KPAIAHRDLK SKNILVKKNG TCCIADLGLA VKFNSDTNEV DVPLSTRVGT
     RRYMAPEVLE ESLNKNHFQA YIMADIYSYG LIVWEMTRRC VTGGMVEDYQ LPYYDMVPSD
     PSFEDMLEVV CVKGLRPTVS NRWNSDECLR AMLKLMSECW AHNPASRLTI LRVKKTLAKM
     VESQDIKI
//
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