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Entry: A0A2I4CP11_9TELE
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ID   A0A2I4CP11_9TELE        Unreviewed;       415 AA.
AC   A0A2I4CP11;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   16-OCT-2019, entry version 12.
DE   SubName: Full=G protein-activated inward rectifier potassium channel 2 {ECO:0000313|RefSeq:XP_013881726.1};
GN   Name=kcnj6 {ECO:0000313|RefSeq:XP_013881726.1};
OS   Austrofundulus limnaeus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae;
OC   Austrofundulus.
OX   NCBI_TaxID=52670 {ECO:0000313|Proteomes:UP000192220, ECO:0000313|RefSeq:XP_013881726.1};
RN   [1] {ECO:0000313|RefSeq:XP_013881726.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JAN-2018) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   RefSeq; XP_013881726.1; XM_014026272.1.
DR   GeneID; 106530619; -.
DR   KEGG; alim:106530619; -.
DR   CTD; 3763; -.
DR   OrthoDB; 956263at2759; -.
DR   Proteomes; UP000192220; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015467; F:G-protein activated inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003275; K_chnl_inward-rec_Kir3.2.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF19; PTHR11767:SF19; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01328; KIR32CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000192220};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609, ECO:0000313|RefSeq:XP_013881726.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192220};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     76     97       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    151    174       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       40    179       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      186    356       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION        1     23       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      372    415       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    383    415       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   SITE        165    165       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   415 AA;  47435 MW;  66F5A0DEC35171FB CRC64;
     MEQDVESPAV RKPKLPKQAR EDLPKQLAEI DRAKRIQRYV QKDGKCNVHH GNVRETYRYL
     TDIFTTLVDL KWRFNLFIFV LVYTVTWLFF GLMWWLIAYL RGDLEHLADN QWTPCVNNLN
     GFVSAFLFSI ETETTIGYGY RVITDKCPEG IVLLLVQSVL GSIVNAFMVG CMFVKISQPK
     KRAETLVFST NAVISMRDGR LCLMFRVGDL RNSHIVEASI RAKLIKSKQT KEGEFIPLNQ
     TDINVGYNTG DDRLFLVSPL IICHEINQHS PFWEISQAHL AKEELEIVVI LEGMVEATGM
     TCQARSSYIS SEIKWGYRFM PVLTLEDGFY EVDYNSFHEV YETNTPTCSA KELSDMANRA
     RLPLTWSLAS KLSQQGLPES EQEGQETKTK VDNEDKAQTA ERNGDIANLE SESKV
//
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