GenomeNet

Database: UniProt
Entry: A0A2I4D0V8_9TELE
LinkDB: A0A2I4D0V8_9TELE
Original site: A0A2I4D0V8_9TELE 
ID   A0A2I4D0V8_9TELE        Unreviewed;      1690 AA.
AC   A0A2I4D0V8;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   05-JUN-2019, entry version 10.
DE   SubName: Full=rap guanine nucleotide exchange factor 6-like isoform X4 {ECO:0000313|RefSeq:XP_013885875.1};
GN   Name=LOC106533947 {ECO:0000313|RefSeq:XP_013885875.1};
OS   Austrofundulus limnaeus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae;
OC   Austrofundulus.
OX   NCBI_TaxID=52670 {ECO:0000313|Proteomes:UP000192220, ECO:0000313|RefSeq:XP_013885875.1};
RN   [1] {ECO:0000313|RefSeq:XP_013885875.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JAN-2018) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   RefSeq; XP_013885875.1; XM_014030421.1.
DR   GeneID; 106533947; -.
DR   OrthoDB; 31139at2759; -.
DR   Proteomes; UP000192220; Genome assembly.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 2.60.120.10; -; 2.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; PTHR23113; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; SSF48366; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   SUPFAM; SSF51206; SSF51206; 2.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000192220};
KW   Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-
KW   ProRule:PRU00168, ECO:0000256|SAAS:SAAS01081641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192220}.
FT   DOMAIN      289    389       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   DOMAIN      421    534       N-terminal Ras-GEF. {ECO:0000259|PROSITE:
FT                                PS50212}.
FT   DOMAIN      539    609       PDZ. {ECO:0000259|PROSITE:PS50106}.
FT   DOMAIN      768    854       Ras-associating. {ECO:0000259|PROSITE:
FT                                PS50200}.
FT   DOMAIN      879   1107       Ras-GEF. {ECO:0000259|PROSITE:PS50009}.
FT   REGION      141    170       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2I4D0V8}.
FT   REGION      184    253       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2I4D0V8}.
FT   REGION     1159   1293       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2I4D0V8}.
FT   REGION     1417   1440       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2I4D0V8}.
FT   REGION     1482   1559       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2I4D0V8}.
FT   REGION     1577   1596       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2I4D0V8}.
FT   REGION     1636   1690       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2I4D0V8}.
FT   COMPBIAS    190    218       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A2I4D0V8}.
FT   COMPBIAS    234    250       Acidic. {ECO:0000256|MobiDB-lite:
FT                                A0A2I4D0V8}.
FT   COMPBIAS   1505   1559       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A2I4D0V8}.
SQ   SEQUENCE   1690 AA;  187433 MW;  A958009D15793B2B CRC64;
     MKMTGAMETS FRLALMKPPS LRTAEDLQFI YCHLYHMEVL THLREHQLRS MCTSARYERL
     EAFHILFYPD SVATCWYILL SGSVLLNGQL LLSKCCFGRQ LGGRRGCECL ILEPSEMIVV
     DNSSEGDDNF LQREGSQRRS RRRFRRVNPR GERELITDGQ EPASFNTNYV NNKLPADLNK
     MHLTDHAHQQ VTHMAPSQSG CSITSDSGSS SLSDIYQATE SELGDGDLSG LPETAVDSEE
     DEEEDEDLDR ASDALLGRDL VRECLEKDPA DRNDDDIEQL LEFMHQLPAF ANMTMSVRRD
     LCSVMMFEVV EQAGTVLLHD KQELDHWYVI LNGAIEISHP EGRAETLCMG NSFGITPSLD
     KQYMNGDVRT KGDDCQFVCI AQEDYWRILN HVEKNMHKVE EEGEIVMVKE HRELDRSGTR
     KGHIVIKGTP ERLIMHLVEE PSVVDPTYIE DFLLTYRTFL SSPMDVGRKL LEWFQMDSLR
     DTVTRIVLLW VNNHFNDFED NPAMTHFLEE FEKHLEATKM KGHLRLLNIA CTAKAKWRQI
     TLQKASRESP LYFSIKGGSE RGFGIFVESV EEGSKAVEAG LKRGDQIMEV NGQNFENISF
     AKAVDILRNN THLSITVKTN IFVCKELLSR IMHEKKNGGP HIPKIQEKKG NRFSIPDLPG
     DLEFPTDQKS ARKMKANTVS GGRNKIRKML EKTRFSILPP KPFRGLFGDG GMGQSQDDSI
     VGTKQCRHSV AIMPIPGNLS SSSPDLLQPA TSLLDFSNLA ALGLYYIPDQ VIRVFKADQQ
     SCYIIISKDT TAKDVVIQTV NEFGLFAAPE TYSLCEVSVS PEGVIKQRRL PDQLSKLADR
     IQLNGRYYLK NNMETETLCS DEDAQDLLRE SQISLLQLST MEVAAQLSMR DFELFRNIES
     TEYVDDLFKL DSSAGCGNLK QFEEVINQET FWVATEILKE PNTLKRMKTI KHFIKIALHC
     RECKNFNSMF AIISGLNLAP VARLRSTWEK LPSKYEKLFR DLQDVFDPSR NMAKYRNVLS
     SQSMQPPIIP LFPVVKKDLT FLHEGNDSNV DGLVNFEKLR MIAKEIRHVV RMTSANMDPA
     LMFRQRSLSQ GSTNSNILDV QGGAHKKRVR RSSLLNAKKL YEDAQMARKV KQYLSNLSVE
     TDEEKHQIMS LQCEPSYNTL SKNLSERRSN KSDMSPVSQR STLPLGKAQN RVSQVLQVQV
     PLNPLRKKST AKDTGTPNSN SPQVVKKPPV SSSDEWSSKR PSDDTISTVS SLHSSPTVSP
     QGSPRKVGGV TKSQNSSQMN LSGSSSSLTS DASTKTGVSL RSYGIGCSLL PGSKMDNLSD
     SSHSEISSRS SICSVDSVPA PGPDDRCNRT CTAASTAAAF ASNPTAATAA EVAEGTAALN
     AHLTADYSQP STSSSALGRG YAVRAFSASL STEELTPDHT SMDSVADSGR GSWTSCSSNS
     HDSFQSLPAS SCRPWDHGIH GPPLSLPHTH LGGFKHTQLT RPIAEVEAAG PTWAAEHPTR
     DSSSDLAEQF RQSWTSSNSL SDNYEGNYGT IKRRNTSEHP SSPANEEGGQ STDPAYKTVT
     SSTDKGLIVY CVTSPTKDER YRAPPPTPPG YHGLALGDLG LTDGVVGGLA GPVPRPPHIR
     PPDYSVALRR SKLLQSPGAA GGLAEVRRLH LQHQDGXTAS STPGHSRPPS NSCPPKDLAD
     SDDDEQVSAV
//
DBGET integrated database retrieval system