ID   A0A2I4E0Z1_JUGRE        Unreviewed;       373 AA.
AC   A0A2I4E0Z1;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Alpha-ketoglutarate-dependent dioxygenase AlkB-like isoform X1 {ECO:0000313|RefSeq:XP_018813063.1};
GN   Name=LOC108985284 {ECO:0000313|RefSeq:XP_018813063.1};
OS   Juglans regia (English walnut).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fagales; Juglandaceae; Juglans.
OX   NCBI_TaxID=51240 {ECO:0000313|Proteomes:UP000235220, ECO:0000313|RefSeq:XP_018813063.1};
RN   [1] {ECO:0000313|RefSeq:XP_018813063.1}
RP   IDENTIFICATION.
RC   TISSUE=Leaves {ECO:0000313|RefSeq:XP_018813063.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|PIRSR:PIRSR604574-2};
CC       Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR604574-2};
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DR   RefSeq; XP_018813063.1; XM_018957518.2.
DR   AlphaFoldDB; A0A2I4E0Z1; -.
DR   STRING; 51240.A0A2I4E0Z1; -.
DR   EnsemblPlants; Jr03_26650_p1; cds.Jr03_26650_p1; Jr03_26650.
DR   GeneID; 108985284; -.
DR   Gramene; Jr03_26650_p1; cds.Jr03_26650_p1; Jr03_26650.
DR   KEGG; jre:108985284; -.
DR   InParanoid; A0A2I4E0Z1; -.
DR   OrthoDB; 63516at2759; -.
DR   Proteomes; UP000235220; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0008198; F:ferrous iron binding; IBA:GO_Central.
DR   GO; GO:0035516; F:oxidative DNA demethylase activity; IBA:GO_Central.
DR   GO; GO:0035515; F:oxidative RNA demethylase activity; IBA:GO_Central.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0035513; P:oxidative RNA demethylation; IBA:GO_Central.
DR   GO; GO:0035552; P:oxidative single-stranded DNA demethylation; IBA:GO_Central.
DR   Gene3D; 2.60.120.590; Alpha-ketoglutarate-dependent dioxygenase AlkB-like; 1.
DR   InterPro; IPR004574; Alkb.
DR   InterPro; IPR027450; AlkB-like.
DR   InterPro; IPR037151; AlkB-like_sf.
DR   InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR   PANTHER; PTHR16557:SF12; 2-OXOGLUTARATE-DEPENDENT DIOXYGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR16557; ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED; 1.
DR   Pfam; PF13532; 2OG-FeII_Oxy_2; 1.
DR   SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR   PROSITE; PS51471; FE2OG_OXY; 1.
PE   4: Predicted;
KW   Dioxygenase {ECO:0000256|ARBA:ARBA00022964,
KW   ECO:0000313|RefSeq:XP_018813063.1};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Iron {ECO:0000256|PIRSR:PIRSR604574-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR604574-2};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000235220}.
FT   DOMAIN          263..373
FT                   /note="Fe2OG dioxygenase"
FT                   /evidence="ECO:0000259|PROSITE:PS51471"
FT   BINDING         281
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604574-2"
FT   BINDING         283
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604574-2"
FT   BINDING         341
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604574-2"
SQ   SEQUENCE   373 AA;  41867 MW;  72C8F4B4F1269D72 CRC64;
     MLLRRASTLS WRYHRIYRPW RYGSSHRIYR LSSMEVWFSS LGNNLNWGNS GVKCSRGIAS
     GISAAPRYDP ILNGSGLGHF GKKQKPAHGG RLKHGRGNSK YGGGTSYSHG FPKAKPYDIC
     LCGNRRSATI STGSLNEMGH TEMEGAKQRV LRPGMVLLKR YITHKEQVEI VKKCRYLGIG
     PGGFYQPGYQ DGAKLRLQMM CLGMKWDPMS RKYDDTRPVD GSEPPCIPRE FSLLVKRAIQ
     DAHALVKKEY HVSNVEDILP LTSPDICIVN FYTTSGRLGL HQDRDESRES LCKGLPVVSL
     SLGDSAEFLY GDQRNVDNAE RIFLESGDVL FFGGKSRHIF HGVSSIIPKS APKALLEETR
     LRPGRLNLTF RQF
//