ID   A0A2I4G6P0_JUGRE        Unreviewed;       670 AA.
AC   A0A2I4G6P0;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Ubiquitin C-terminal hydrolase 22-like {ECO:0000313|RefSeq:XP_018839559.2};
GN   Name=LOC109005202 {ECO:0000313|RefSeq:XP_018839559.2};
OS   Juglans regia (English walnut).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fagales; Juglandaceae; Juglans.
OX   NCBI_TaxID=51240 {ECO:0000313|Proteomes:UP000235220, ECO:0000313|RefSeq:XP_018839559.2};
RN   [1] {ECO:0000313|RefSeq:XP_018839559.2}
RP   IDENTIFICATION.
RC   TISSUE=Leaves {ECO:0000313|RefSeq:XP_018839559.2};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase C19 family.
CC       {ECO:0000256|ARBA:ARBA00009085}.
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DR   RefSeq; XP_018839559.2; XM_018984014.2.
DR   AlphaFoldDB; A0A2I4G6P0; -.
DR   STRING; 51240.A0A2I4G6P0; -.
DR   KEGG; jre:109005202; -.
DR   InParanoid; A0A2I4G6P0; -.
DR   OrthoDB; 227085at2759; -.
DR   Proteomes; UP000235220; Chromosome 11.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001394; Peptidase_C19_UCH.
DR   InterPro; IPR018200; USP_CS.
DR   InterPro; IPR028889; USP_dom.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001607; Znf_UBP.
DR   PANTHER; PTHR21646:SF49; UBIQUITIN C-TERMINAL HYDROLASE 22; 1.
DR   PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR   Pfam; PF00443; UCH; 1.
DR   Pfam; PF02148; zf-UBP; 1.
DR   SMART; SM00290; ZnF_UBP; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS00972; USP_1; 1.
DR   PROSITE; PS50235; USP_3; 1.
DR   PROSITE; PS50271; ZF_UBP; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|RefSeq:XP_018839559.2};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000235220};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00502}.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           29..670
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5030048785"
FT   TRANSMEM        55..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        80..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          146..245
FT                   /note="UBP-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50271"
FT   DOMAIN          297..641
FT                   /note="USP"
FT                   /evidence="ECO:0000259|PROSITE:PS50235"
SQ   SEQUENCE   670 AA;  76215 MW;  F403E6DC2AE32D42 CRC64;
     MNLHLPPCFQ TVFLALPLSL SLFRSVNTSQ SYSEVQLSKN LQSTNPSLFI PQNLQIQYQF
     LFFVRLFFFN YSVEKIESLS FAITQLFISF LISTFFLTNF FLICNKSKPL SISINMTTGN
     PSYTSPKPCK HLADYKLSHG LSGYKYLQKY LKTTPPGRTS VEKPDTKIPR CISCDGIQGR
     LYFCLICSSV SCLDHTLLHT QSENGHDVAV DIERAELYCC VCCDQVYDPD FDRAVMSKQI
     MGIPRGKNGD ESIGERLVKR RRLGSGVGQE LVDLKISKHL ISLRDRRAKS CYPLGLRGLN
     NLGSTCFMNS VLQALLHAPP FRNYFLSEGH NHENCRKRSV DRLCLACDID GIFSAAFSGD
     RAPYSPAQFL YSWWQHSANL ASYEQQDAHE FFISVLDGIH EKEGKSRNQS GDNGDCQCIA
     HRVFSGLLRS DVTCMTCGFT STTFDPCVDV SLDLDTSNFP PTNIANKPTK PDGNSSMSTL
     LGCLDLFTRQ EKLGSDPKLY CRNCQERRDS VKQMSIKRLP LVLCLHIKRF EHSPVRRTSR
     KIDRYLHFPF SMDMTPYLSS SIVRNRFGNR IFAFEGDESD ISTEFEIFAV VTHAGTLESG
     HYVTYLRLRN QWYKCDDAWI NEVDEAIVRA SQCYMMFYVQ KMLYHKANED LSCLPISPLR
     DTFIPIPGCC
//