ID A0A2I4GJM1_JUGRE Unreviewed; 964 AA.
AC A0A2I4GJM1;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN Name=LOC109008450 {ECO:0000313|RefSeq:XP_018844089.1};
GN ORFNames=F2P56_015083 {ECO:0000313|EMBL:KAF5465051.1};
OS Juglans regia (English walnut).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fagales; Juglandaceae; Juglans.
OX NCBI_TaxID=51240 {ECO:0000313|Proteomes:UP000235220, ECO:0000313|RefSeq:XP_018844089.1};
RN [1] {ECO:0000313|EMBL:KAF5465051.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaves {ECO:0000313|EMBL:KAF5465051.1};
RA Martinez-Garcia P.J., Crepeau M.W., Puiu D., Gonzalez-Ibeas D., Whalen J.,
RA Stevens K., Paul R., Butterfield T., Britton M., Reagan R., Chakraborty S.,
RA Walawage S.L., Vasquez-Gross H.A., Cardeno C., Famula R., Pratt K.,
RA Kuruganti S., Aradhya M.K., Leslie C.A., Dandekar A.M., Salzberg S.L.,
RA Wegrzyn J.L., Langley C.H., Neale D.B.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KAF5465051.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaves {ECO:0000313|EMBL:KAF5465051.1};
RA Marrano A., Britton M., Zimin A.V., Zaini P.A., Workman R., Puiu D.,
RA Bianco L., Allen B.J., Troggio M., Leslie C.A., Timp W., Dendekar A.,
RA Salzberg S.L., Neale D.B.;
RT "Walnut 2.0.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:XP_018844089.1}
RP IDENTIFICATION.
RC TISSUE=Leaves {ECO:0000313|RefSeq:XP_018844089.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
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DR EMBL; LIHL02000007; KAF5465051.1; -; Genomic_DNA.
DR RefSeq; XP_018844089.1; XM_018988544.2.
DR STRING; 51240.A0A2I4GJM1; -.
DR EnsemblPlants; Jr07_14450_p1; cds.Jr07_14450_p1; Jr07_14450.
DR GeneID; 109008450; -.
DR Gramene; Jr07_14450_p1; cds.Jr07_14450_p1; Jr07_14450.
DR KEGG; jre:109008450; -.
DR OrthoDB; 1043at2759; -.
DR Proteomes; UP000235220; Chromosome 7.
DR Proteomes; UP000619265; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0009330; C:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IBA:GO_Central.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR HAMAP; MF_01897; GyrA; 1.
DR InterPro; IPR005743; GyrA.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR NCBIfam; TIGR01063; gyrA; 1.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 6.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000235220};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 111..567
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT REGION 52..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 964 AA; 105662 MW; 468DFB28675B33C2 CRC64;
MKLSYFLSDP SSMALSSGLR FSSILLRYRP SLPLAPTRFS SSLSHRRSEL RFLSGSPSSS
SPPSRTVRSA AIKSRRSDDA DGDEGQDGNG SVLVKGRVGN AGGDGGRVVP TELHKEATEA
YMAYAMSVLL GRALPDVRDG LKPVHRRILF AMHELGLSSR KPFKKCARVV GEVLGKFHPH
GDTAVYDSLV RMAQDFSLRC PLINGHGNFG SIDADPPAAM RYTECRLEAL TEAMLLADLE
QDTVDFVPNF DNSQKEPSLL PARLPTLLLN GSSGIAVGMA TNIPPHNLGE LVDVLCALIH
NPEATLQELL EYMPGPDFPT GGVIMGNIGI LEAYRTGRGR VTVRGKTDVE VLDSKTKRAA
IIIKEIPYQT NKSALVEKIA ELVESKSLDG ISDIRDESDR SGMRIVIELK RGSDPLIVLN
NLYRLTSLQS GFSCNMVGIL DRQPKLMGLR ELLQAFLDFR CSVIERRARF KLSQAQERRH
IVEGIVVGLD NIDGVIRIIR EALSNAAASA GLRNEYNLSE KQAEAILDIN LRRLTLLERK
KFVDESKSLM EQISKLEELL SSKKHILQVI EHEAIELKNK FSSPRRSMLE DSDSGQLEDI
DVIPNEEMLL VLSEKGYVKR MKPNTFNLQN RGTIGKSIGK LRVNDAMSDF IVCRAHDHIL
YFSDKGIVYT ARAYKIPECT RTAAGTPLVQ ILSLTDGERI TSVIPVSDFA GDQFLLMLTM
NGYVKKVSLS SFSSIRSTGI IAIQLVPGDE LKWVRCCTND DLVAMASQNG MVTLTSCETI
RAQGRNTRGA VAMRLKGEDK IASMDIIPAA KRKELEMVTE ANPSSTKRLS GPWLLFLSES
GFGKRVPLSS FRASPLNRVG LIGYKFSAED RLAAVFVVGF SLAEDGESDE QVVLVSQSGT
VNRIKVRDVS IQSRYARGVI LMRLDHTGKI QSASLISATD TDPEEEIASE AAAVHGQVSL
GASA
//
