ID A0A2I4H7X7_JUGRE Unreviewed; 469 AA.
AC A0A2I4H7X7;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Cysteine proteinase RD21A-like {ECO:0000313|RefSeq:XP_018852257.1};
GN Name=LOC109014296 {ECO:0000313|RefSeq:XP_018852257.1};
GN ORFNames=F2P56_012385 {ECO:0000313|EMBL:KAF5468212.1};
OS Juglans regia (English walnut).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fagales; Juglandaceae; Juglans.
OX NCBI_TaxID=51240 {ECO:0000313|Proteomes:UP000235220, ECO:0000313|RefSeq:XP_018852257.1};
RN [1] {ECO:0000313|EMBL:KAF5468212.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaves {ECO:0000313|EMBL:KAF5468212.1};
RA Martinez-Garcia P.J., Crepeau M.W., Puiu D., Gonzalez-Ibeas D., Whalen J.,
RA Stevens K., Paul R., Butterfield T., Britton M., Reagan R., Chakraborty S.,
RA Walawage S.L., Vasquez-Gross H.A., Cardeno C., Famula R., Pratt K.,
RA Kuruganti S., Aradhya M.K., Leslie C.A., Dandekar A.M., Salzberg S.L.,
RA Wegrzyn J.L., Langley C.H., Neale D.B.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KAF5468212.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaves {ECO:0000313|EMBL:KAF5468212.1};
RA Marrano A., Britton M., Zimin A.V., Zaini P.A., Workman R., Puiu D.,
RA Bianco L., Allen B.J., Troggio M., Leslie C.A., Timp W., Dendekar A.,
RA Salzberg S.L., Neale D.B.;
RT "Walnut 2.0.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:XP_018852257.1}
RP IDENTIFICATION.
RC TISSUE=Leaves {ECO:0000313|RefSeq:XP_018852257.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; LIHL02000006; KAF5468212.1; -; Genomic_DNA.
DR RefSeq; XP_018852257.1; XM_018996712.2.
DR STRING; 51240.A0A2I4H7X7; -.
DR EnsemblPlants; Jr06_06340_p1; cds.Jr06_06340_p1; Jr06_06340.
DR GeneID; 109014296; -.
DR Gramene; Jr06_06340_p1; cds.Jr06_06340_p1; Jr06_06340.
DR KEGG; jre:109014296; -.
DR OrthoDB; 5472443at2759; -.
DR Proteomes; UP000235220; Chromosome 6.
DR Proteomes; UP000619265; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IBA:GO_Central.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 2.10.25.160; Granulin; 1.
DR InterPro; IPR000118; Granulin.
DR InterPro; IPR037277; Granulin_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF937; CYSTEINE PROTEINASE RD21A; 1.
DR Pfam; PF00396; Granulin; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00277; GRAN; 1.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF57277; Granulin repeat; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000235220};
KW Signal {ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..469
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041063085"
FT DOMAIN 52..109
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 140..356
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
FT DOMAIN 379..436
FT /note="Granulins"
FT /evidence="ECO:0000259|SMART:SM00277"
SQ SEQUENCE 469 AA; 51735 MW; 538E3CB3E07FACC6 CRC64;
MAFCRPSSTM VIVLFVTIFT LSSALDMSII GYDENHGDRS SWRTNEEVMA IYEGWLAKHG
RAYNAIGEKE KRFEIFKDNL RFIDEHNADK NRTYKLGLNR FADLTNEEYR TTYLGAKFSS
KRRLSRPSSN RYEPRVGDKL PESVDWRKEG AVVDVKDQGS CGSCWAFSTI AAVEGINKIV
TGDLISLSEQ ELVDCDTSYN EGCNGGLMDY AFEFIINNGG IDTEEDYPYY ASDGTCDTYR
KNARVVTIDE YEDVPANNEK ALRKAVANQP VSIAIEGGGR EFQLYDSGVF TGKCGTSLDH
GVTAVGYGTD NGVDYWIVKN SWGASWGEAG YIRMERNLDG TSTGKCGIAM EASYPIKKSQ
NPPNPGPSPP SPIKPPTVCS SYFSCPDSNT CCCTYEYSGY CLAWGCCPLE GATCCDDHYS
CCPHDYPICN TNDGTCMMSK DNPLAVKALR RTPAKPHWAF GSGGKKSSA
//
