ID A0A2I4H8M2_JUGRE Unreviewed; 542 AA.
AC A0A2I4H8M2;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Signal peptide peptidase-like 2 {ECO:0000313|RefSeq:XP_018852497.1};
GN Name=LOC109014473 {ECO:0000313|RefSeq:XP_018852497.1};
GN ORFNames=F2P56_004826 {ECO:0000313|EMBL:KAF5478250.1};
OS Juglans regia (English walnut).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fagales; Juglandaceae; Juglans.
OX NCBI_TaxID=51240 {ECO:0000313|Proteomes:UP000235220, ECO:0000313|RefSeq:XP_018852497.1};
RN [1] {ECO:0000313|EMBL:KAF5478250.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaves {ECO:0000313|EMBL:KAF5478250.1};
RA Martinez-Garcia P.J., Crepeau M.W., Puiu D., Gonzalez-Ibeas D., Whalen J.,
RA Stevens K., Paul R., Butterfield T., Britton M., Reagan R., Chakraborty S.,
RA Walawage S.L., Vasquez-Gross H.A., Cardeno C., Famula R., Pratt K.,
RA Kuruganti S., Aradhya M.K., Leslie C.A., Dandekar A.M., Salzberg S.L.,
RA Wegrzyn J.L., Langley C.H., Neale D.B.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KAF5478250.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaves {ECO:0000313|EMBL:KAF5478250.1};
RA Marrano A., Britton M., Zimin A.V., Zaini P.A., Workman R., Puiu D.,
RA Bianco L., Allen B.J., Troggio M., Leslie C.A., Timp W., Dendekar A.,
RA Salzberg S.L., Neale D.B.;
RT "Walnut 2.0.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:XP_018852497.1}
RP IDENTIFICATION.
RC TISSUE=Leaves {ECO:0000313|RefSeq:XP_018852497.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Intramembrane-cleaving aspartic protease (I-CLiP) that
CC cleaves type II membrane signal peptides in the hydrophobic plane of
CC the membrane. {ECO:0000256|ARBA:ARBA00003012}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the peptidase A22B family.
CC {ECO:0000256|ARBA:ARBA00006859}.
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DR EMBL; LIHL02000002; KAF5478250.1; -; Genomic_DNA.
DR RefSeq; XP_018852497.1; XM_018996952.2.
DR STRING; 51240.A0A2I4H8M2; -.
DR EnsemblPlants; Jr02_17770_p1; cds.Jr02_17770_p1; Jr02_17770.
DR GeneID; 109014473; -.
DR Gramene; Jr02_17770_p1; cds.Jr02_17770_p1; Jr02_17770.
DR KEGG; jre:109014473; -.
DR OrthoDB; 51438at2759; -.
DR Proteomes; UP000235220; Chromosome 2.
DR Proteomes; UP000619265; Unassembled WGS sequence.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030660; C:Golgi-associated vesicle membrane; IBA:GO_Central.
DR GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR GO; GO:0042500; F:aspartic endopeptidase activity, intramembrane cleaving; IBA:GO_Central.
DR GO; GO:0033619; P:membrane protein proteolysis; IBA:GO_Central.
DR CDD; cd02132; PA_GO-like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007369; Peptidase_A22B_SPP.
DR InterPro; IPR006639; Preselin/SPP.
DR PANTHER; PTHR12174:SF75; INTRAMEMBRANE PROTEASE (IMPAS) FAMILY; 1.
DR PANTHER; PTHR12174; SIGNAL PEPTIDE PEPTIDASE; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04258; Peptidase_A22B; 1.
DR SMART; SM00730; PSN; 1.
DR SUPFAM; SSF52025; PA domain; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000235220};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..542
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041063188"
FT TRANSMEM 197..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 276..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 317..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 463..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 490..509
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 93..170
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
SQ SEQUENCE 542 AA; 59839 MW; B5D0FE6F47C0AFD9 CRC64;
MDLQRPCWVV FVLALISIVC HPWNARAGDI VHDDDLAPKK PGCENDFVLV KIQTWVDGIE
DAEFVGVGAR FGTTIVSKEK NANQSRLTLS DPRDCCSKPK KKLAGDVVIV HRGNCKFTTK
ANVAEAAGAS ALLIVNNQKE LYKMVCEPDE TDLDIHIPAV MLPQDAGASL EKMLMNSSRV
SVQLYSPRRP VVDIAEVFLW LMAVGTILCA SYWSAWSARE AAIEQDKLIK DAVDEIPSTK
AMGTSGVVDI NITSAVLFVV IASCFLVILY KLMSFWFVEL LVVLFCIGGI EGLQTCLVAL
LSRCFKRPGA SYIKVPFFGA ITYLTLAVSP LCIAFAVVWA VYRNVSFAWI GQDILGIALI
ITVLQIVHVP NLKVGTVLLS CAFLYDIFWV FVSKKLFHES VMIVVARGDK SGEDGIPMLL
KIPRMFDPWG GYSIIGFGDI LLPGLLIAFS LRYDWLANKT LRAGYFLWAM LAYGLGLLIT
YVALNLMDGH GQPALLYIVP FTLGTFLALG KKRGDLRVLW SRGEPERPCP HVQLQHSEES
NE
//
