ID A0A2I4HIY0_JUGRE Unreviewed; 315 AA.
AC A0A2I4HIY0;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase {ECO:0000256|ARBA:ARBA00012526};
DE EC=2.7.7.60 {ECO:0000256|ARBA:ARBA00012526};
GN Name=LOC109018335 {ECO:0000313|RefSeq:XP_018856123.1};
OS Juglans regia (English walnut).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fagales; Juglandaceae; Juglans.
OX NCBI_TaxID=51240 {ECO:0000313|Proteomes:UP000235220, ECO:0000313|RefSeq:XP_018856123.1};
RN [1] {ECO:0000313|RefSeq:XP_018856123.1}
RP IDENTIFICATION.
RC TISSUE=Leaves {ECO:0000313|RefSeq:XP_018856123.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis
CC via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-
CC phosphate: step 2/6. {ECO:0000256|ARBA:ARBA00004787}.
CC -!- SIMILARITY: Belongs to the IspD/TarI cytidylyltransferase family. IspD
CC subfamily. {ECO:0000256|ARBA:ARBA00009789}.
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DR RefSeq; XP_018856123.1; XM_019000578.2.
DR AlphaFoldDB; A0A2I4HIY0; -.
DR EnsemblPlants; Jr16_22850_p1; cds.Jr16_22850_p1; Jr16_22850.
DR GeneID; 109018335; -.
DR Gramene; Jr16_22850_p1; cds.Jr16_22850_p1; Jr16_22850.
DR InParanoid; A0A2I4HIY0; -.
DR OrthoDB; 1214813at2759; -.
DR UniPathway; UPA00056; UER00093.
DR Proteomes; UP000235220; Chromosome 16.
DR GO; GO:0050518; F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0019288; P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway; IEA:UniProtKB-UniPathway.
DR CDD; cd02516; CDP-ME_synthetase; 1.
DR HAMAP; MF_00108; IspD; 1.
DR InterPro; IPR001228; IspD.
DR InterPro; IPR034683; IspD/TarI.
DR InterPro; IPR018294; ISPD_synthase_CS.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR NCBIfam; TIGR00453; ispD; 1.
DR PANTHER; PTHR32125; 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR32125:SF4; 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE, CHLOROPLASTIC; 1.
DR Pfam; PF01128; IspD; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR PROSITE; PS01295; ISPD; 1.
PE 3: Inferred from homology;
KW Isoprene biosynthesis {ECO:0000256|ARBA:ARBA00023229};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|RefSeq:XP_018856123.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000235220};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ SEQUENCE 315 AA; 34717 MW; 914335453635B759 CRC64;
MAIILPVDLS FPLPSAATSL IFSFSCSIFQ SNRRIPVKSI PVSLSNSNFT FPFPGPKFDF
REKGRSGRSR ITPYCAENSD KEKSRIVKEK SVSVILLAGG KGKRMGASMP KQYLPLLGQP
IALYSLYTFS RLIQVKEIIV VCDPSYKDIF EGKLCVEVKF TLPGKERQDS VYSGLQAVDS
SSELVCIHDS ARPLVSTGDI EKVLKDGWLN GAAVLGVPVK ATIKEANSQS FVVRTLDRKK
LWEMQTPQVI KPDLLNKGFE LVNRGGLEVT DDVSIVEHLK HPVYITEGSY TNIKVTTPDD
LLLAERIMSL STGDG
//
