ID A0A2I4HVW1_JUGRE Unreviewed; 446 AA.
AC A0A2I4HVW1;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Probable eukaryotic translation initiation factor 5-1 {ECO:0000313|RefSeq:XP_018860284.2};
GN Name=LOC109021983 {ECO:0000313|RefSeq:XP_018860284.2};
GN ORFNames=F2P56_031124 {ECO:0000313|EMBL:KAF5450804.1};
OS Juglans regia (English walnut).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fagales; Juglandaceae; Juglans.
OX NCBI_TaxID=51240 {ECO:0000313|Proteomes:UP000235220, ECO:0000313|RefSeq:XP_018860284.2};
RN [1] {ECO:0000313|EMBL:KAF5450804.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaves {ECO:0000313|EMBL:KAF5450804.1};
RA Martinez-Garcia P.J., Crepeau M.W., Puiu D., Gonzalez-Ibeas D., Whalen J.,
RA Stevens K., Paul R., Butterfield T., Britton M., Reagan R., Chakraborty S.,
RA Walawage S.L., Vasquez-Gross H.A., Cardeno C., Famula R., Pratt K.,
RA Kuruganti S., Aradhya M.K., Leslie C.A., Dandekar A.M., Salzberg S.L.,
RA Wegrzyn J.L., Langley C.H., Neale D.B.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KAF5450804.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaves {ECO:0000313|EMBL:KAF5450804.1};
RA Marrano A., Britton M., Zimin A.V., Zaini P.A., Workman R., Puiu D.,
RA Bianco L., Allen B.J., Troggio M., Leslie C.A., Timp W., Dendekar A.,
RA Salzberg S.L., Neale D.B.;
RT "Walnut 2.0.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:XP_018860284.2}
RP IDENTIFICATION.
RC TISSUE=Leaves {ECO:0000313|RefSeq:XP_018860284.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the eIF-2-beta/eIF-5 family.
CC {ECO:0000256|ARBA:ARBA00010397}.
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DR EMBL; LIHL02000013; KAF5450804.1; -; Genomic_DNA.
DR RefSeq; XP_018860284.2; XM_019004739.2.
DR STRING; 51240.A0A2I4HVW1; -.
DR EnsemblPlants; Jr13_27090_p1; cds.Jr13_27090_p1; Jr13_27090.
DR Gramene; Jr13_27090_p1; cds.Jr13_27090_p1; Jr13_27090.
DR KEGG; jre:109021983; -.
DR OrthoDB; 5475947at2759; -.
DR Proteomes; UP000235220; Chromosome 13.
DR Proteomes; UP000619265; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0071074; F:eukaryotic initiation factor eIF2 binding; IBA:GO_Central.
DR GO; GO:0005092; F:GDP-dissociation inhibitor activity; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IBA:GO_Central.
DR GO; GO:0001731; P:formation of translation preinitiation complex; IBA:GO_Central.
DR CDD; cd11561; W2_eIF5; 1.
DR Gene3D; 1.25.40.180; -; 1.
DR Gene3D; 2.20.25.350; -; 1.
DR Gene3D; 3.30.30.170; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045196; IF2/IF5.
DR InterPro; IPR002735; Transl_init_fac_IF2/IF5_dom.
DR InterPro; IPR016189; Transl_init_fac_IF2/IF5_N.
DR InterPro; IPR016190; Transl_init_fac_IF2/IF5_Zn-bd.
DR InterPro; IPR003307; W2_domain.
DR PANTHER; PTHR23001; EUKARYOTIC TRANSLATION INITIATION FACTOR; 1.
DR PANTHER; PTHR23001:SF52; EUKARYOTIC TRANSLATION INITIATION FACTOR 5-2-RELATED; 1.
DR Pfam; PF01873; eIF-5_eIF-2B; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00653; eIF2B_5; 1.
DR SMART; SM00515; eIF5C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF100966; Translation initiation factor 2 beta, aIF2beta, N-terminal domain; 1.
DR SUPFAM; SSF75689; Zinc-binding domain of translation initiation factor 2 beta; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|RefSeq:XP_018860284.2};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000235220}.
FT DOMAIN 290..446
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 143..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 267..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..225
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 446 AA; 49398 MW; E02B477E7AE8C330 CRC64;
MALQNIGASN RDDAFYRYKM PKMVTKIEGR GNGIKTNVVN MVEIAKALAR PASYTTKYFG
CELGAQSKFD DKTGTSLVNG AHDTAKLAAL LENFIKKYVQ CYGCGNPETE IVITKTQMIT
LKCAACGFLS DVDMRDKLTT FILKNPPEQK KSSKDKKAMR RAEKERLKEG EAADEEMKKL
KKEAVKKKGS SASAKDVASK ALTKKRSNSS DEDHSPARSH ADENETPADD DDEDVQWQTD
TSLEAARQRI QEQLSAVTAD MVMLSTNEEK QKSAKKSPGR EEKNQVNGLS NGHTSAHGNL
VDEIREHLNK GSSPSQLKSF LGSLSGTYQE IMDALFEALF MGFDKGFAKE VAKKKNYLAA
ATQEEGSQMV LLRAIESFSG KASTKAVKEL GLVLKELYDH DVLEESSILE WYQQGLGGGN
KTSQIWKNLK PFIEWLQNAE SESEEE
//
