ID A0A2I6PFW6_9CAUD Unreviewed; 404 AA.
AC A0A2I6PFW6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN ORFNames=phiP43_265 {ECO:0000313|EMBL:AUM58623.1};
OS Proteus phage phiP4-3.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Straboviridae; Bragavirus; Bragavirus p43.
OX NCBI_TaxID=2065203 {ECO:0000313|EMBL:AUM58623.1, ECO:0000313|Proteomes:UP000240538};
RN [1] {ECO:0000313|EMBL:AUM58623.1, ECO:0000313|Proteomes:UP000240538}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA He Y., Yang H.;
RT "Complete genome sequence and characterization of bacteriophage phiP4-3
RT infecting Proteus pennea.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the type II topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00011080}.
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DR EMBL; MG696114; AUM58623.1; -; Genomic_DNA.
DR Proteomes; UP000240538; Genome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.670; -; 1.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR001241; Topo_IIA.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013759; Topo_IIA_B_C.
DR InterPro; IPR013506; Topo_IIA_bsu_dom2.
DR PANTHER; PTHR10169:SF38; DNA TOPOISOMERASE 2; 1.
DR PANTHER; PTHR10169; DNA TOPOISOMERASE/GYRASE; 1.
DR Pfam; PF00204; DNA_gyraseB; 1.
DR PRINTS; PR00418; TPI2FAMILY.
DR SMART; SM00433; TOP2c; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000313|EMBL:AUM58623.1}.
FT DOMAIN 60..181
FT /note="DNA topoisomerase type IIA subunit B"
FT /evidence="ECO:0000259|Pfam:PF00204"
SQ SEQUENCE 404 AA; 46177 MW; 2BF3A8CEAF9B9C31 CRC64;
MTLDRLMTLA VVFPSIEFKF NGKKVVGNFK KYSKQFDEES IVLDQNNCSI AIGRSPDGFR
HISYVNNIHT KKGGSHVDWL MDELCTELMP MIKRKFKIDI TKARIKECLT LLLFVRDMSN
LKFDSQTKER LSNTWGEVKN HVDIDVKKLA SQLMRNEAVL MPIIEAVLAR KLAAEQAAAT
KAAKKAAKAK VAKHIKANLY GKPGTGTTLF LTEGDSALNE LLTSRDQDTQ CGYPLRGKFL
NTWGMKDVDI MASKEAFDIM AITGLVLGEK PENLMYDNIA IMTDADVDGQ GSIYPSLLAF
FAKWPELYKE QRIRFCKTPL IIIQKGKEQK WYYNAEEYEK EKPKLKGWSS PRYIKGLASL
TSEEYERVLK KPVYDVVELP DNYKELFEML FGDNAELRKE WMKS
//
