ID A0A2I6S8U8_9RHOO Unreviewed; 275 AA.
AC A0A2I6S8U8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN Name=cobA {ECO:0000313|EMBL:AUN95672.1};
GN ORFNames=C0099_12485 {ECO:0000313|EMBL:AUN95672.1};
OS Pseudazoarcus pumilus.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Rhodocyclales; Zoogloeaceae;
OC Pseudazoarcus.
OX NCBI_TaxID=2067960 {ECO:0000313|EMBL:AUN95672.1, ECO:0000313|Proteomes:UP000242205};
RN [1] {ECO:0000313|EMBL:AUN95672.1, ECO:0000313|Proteomes:UP000242205}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SY39 {ECO:0000313|EMBL:AUN95672.1,
RC ECO:0000313|Proteomes:UP000242205};
RA Fu G.-Y.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Porphyrin-containing compound metabolism; siroheme
CC biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1.
CC {ECO:0000256|ARBA:ARBA00025705}.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879, ECO:0000256|RuleBase:RU003960}.
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DR EMBL; CP025682; AUN95672.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2I6S8U8; -.
DR KEGG; atw:C0099_12485; -.
DR OrthoDB; 9815856at2; -.
DR UniPathway; UPA00262; UER00211.
DR Proteomes; UP000242205; Chromosome.
DR GO; GO:0004851; F:uroporphyrin-III C-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0019354; P:siroheme biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd11642; SUMT; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR006366; CobA/CysG_C.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR NCBIfam; TIGR01469; cobA_cysG_Cterm; 1.
DR PANTHER; PTHR45790:SF1; SIROHEME SYNTHASE; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
DR PROSITE; PS00840; SUMT_2; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|RuleBase:RU003960};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Reference proteome {ECO:0000313|Proteomes:UP000242205};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003960}.
FT DOMAIN 18..228
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
SQ SEQUENCE 275 AA; 28738 MW; 9509FEF26557F129 CRC64;
MSIPAIRNAR PGPQPGCVYL VGAGPGDPEL LTLRGATLLA GADVVLYDNL VSARILELAP
ASAERIYVGK KAADHVLPQD EINALLVRHA REGRRVVRLK GGDPFIFGRG GEEIEALVDA
GITFEVVPGV TAAAGVAAYA GIPLTHRDHA QSVVFATGFL KDGALDLDWP MLARGGQTLV
IYMGISRLAD ICARLVEHGL AEDTPAGVIE RGTTDAQRVC VGTLADLADR VREAGIRPPA
LTVVGGVVGL YPRLAWFAAS GEGGREATER GAGRD
//
