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Database: UniProt
Entry: A0A2I7N3Q4_9NEIS
LinkDB: A0A2I7N3Q4_9NEIS
Original site: A0A2I7N3Q4_9NEIS 
ID   A0A2I7N3Q4_9NEIS        Unreviewed;       158 AA.
AC   A0A2I7N3Q4;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Transcription elongation factor GreA {ECO:0000256|ARBA:ARBA00013729, ECO:0000256|HAMAP-Rule:MF_00105};
DE   AltName: Full=Transcript cleavage factor GreA {ECO:0000256|HAMAP-Rule:MF_00105};
GN   Name=greA {ECO:0000256|HAMAP-Rule:MF_00105};
GN   ORFNames=CUN60_01710 {ECO:0000313|EMBL:AUR51073.1};
OS   Aquella oligotrophica.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Aquella.
OX   NCBI_TaxID=2067065 {ECO:0000313|EMBL:AUR51073.1, ECO:0000313|Proteomes:UP000236655};
RN   [1] {ECO:0000313|Proteomes:UP000236655}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 100970 {ECO:0000313|Proteomes:UP000236655};
RA   Chan K.G., Lee L.S.;
RL   Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Necessary for efficient RNA polymerase transcription
CC       elongation past template-encoded arresting sites. The arresting sites
CC       in DNA have the property of trapping a certain fraction of elongating
CC       RNA polymerases that pass through, resulting in locked ternary
CC       complexes. Cleavage of the nascent transcript by cleavage factors such
CC       as GreA or GreB allows the resumption of elongation from the new
CC       3'terminus. GreA releases sequences of 2 to 3 nucleotides.
CC       {ECO:0000256|ARBA:ARBA00024916, ECO:0000256|HAMAP-Rule:MF_00105,
CC       ECO:0000256|RuleBase:RU000556}.
CC   -!- SIMILARITY: Belongs to the GreA/GreB family.
CC       {ECO:0000256|ARBA:ARBA00008213, ECO:0000256|HAMAP-Rule:MF_00105,
CC       ECO:0000256|RuleBase:RU000556}.
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DR   EMBL; CP024847; AUR51073.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2I7N3Q4; -.
DR   KEGG; nba:CUN60_01710; -.
DR   OrthoDB; 9808774at2; -.
DR   Proteomes; UP000236655; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0070063; F:RNA polymerase binding; IEA:InterPro.
DR   GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0032784; P:regulation of DNA-templated transcription elongation; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.10.50.30; Transcription elongation factor, GreA/GreB, C-terminal domain; 1.
DR   Gene3D; 1.10.287.180; Transcription elongation factor, GreA/GreB, N-terminal domain; 1.
DR   HAMAP; MF_00105; GreA_GreB; 1.
DR   InterPro; IPR036953; GreA/GreB_C_sf.
DR   InterPro; IPR018151; TF_GreA/GreB_CS.
DR   InterPro; IPR006359; Tscrpt_elong_fac_GreA.
DR   InterPro; IPR028624; Tscrpt_elong_fac_GreA/B.
DR   InterPro; IPR001437; Tscrpt_elong_fac_GreA/B_C.
DR   InterPro; IPR023459; Tscrpt_elong_fac_GreA/B_fam.
DR   InterPro; IPR022691; Tscrpt_elong_fac_GreA/B_N.
DR   InterPro; IPR036805; Tscrpt_elong_fac_GreA/B_N_sf.
DR   NCBIfam; TIGR01462; greA; 1.
DR   PANTHER; PTHR30437; TRANSCRIPTION ELONGATION FACTOR GREA; 1.
DR   PANTHER; PTHR30437:SF4; TRANSCRIPTION ELONGATION FACTOR GREA; 1.
DR   Pfam; PF01272; GreA_GreB; 1.
DR   Pfam; PF03449; GreA_GreB_N; 1.
DR   PIRSF; PIRSF006092; GreA_GreB; 1.
DR   SUPFAM; SSF54534; FKBP-like; 1.
DR   SUPFAM; SSF46557; GreA transcript cleavage protein, N-terminal domain; 1.
DR   PROSITE; PS00829; GREAB_1; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW   Rule:MF_00105}; Elongation factor {ECO:0000313|EMBL:AUR51073.1};
KW   Protein biosynthesis {ECO:0000313|EMBL:AUR51073.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000236655};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW   Rule:MF_00105};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW   Rule:MF_00105}.
FT   DOMAIN          4..74
FT                   /note="Transcription elongation factor GreA/GreB N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03449"
FT   DOMAIN          82..156
FT                   /note="Transcription elongation factor GreA/GreB C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01272"
SQ   SEQUENCE   158 AA;  17548 MW;  93B17154C2CEA03B CRC64;
     MQRIPMTQNG AKLLEEELIR LKGAERSAVI QAIAEARSHG DISENAEYDA AKEKQAFIEA
     RIAEIEAKLS RAEIITPSQL NSDGRVVFGA IIDLLDMESE EEVEYQIVGD DEADIKHKKI
     SVNTPVARSL IGKICGDVVE VKVPNGIKEY EILNIRFE
//
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