ID A0A2I7R1C4_9CAUD Unreviewed; 177 AA.
AC A0A2I7R1C4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=dihydrofolate reductase {ECO:0000256|ARBA:ARBA00012856};
DE EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856};
GN ORFNames=NVP1101O_042 {ECO:0000313|EMBL:AUR87453.1};
OS Vibrio phage 1.101.O._10N.261.45.C6.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes.
OX NCBI_TaxID=2070725 {ECO:0000313|EMBL:AUR87453.1, ECO:0000313|Proteomes:UP000273409};
RN [1] {ECO:0000313|EMBL:AUR87453.1, ECO:0000313|Proteomes:UP000273409}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Kauffman K.M., Hussain F.A., Yang J., Arevalo P., Brown J.M., Chang W.K.,
RA VanInsberghe D., Elsherbini J., Cutler M.B., Kelly L., Polz M.F.;
RT "A major lineage of nontailed dsDNA viruses as unrecognized killers of
RT marine bacteria.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the dihydrofolate reductase family.
CC {ECO:0000256|RuleBase:RU004474}.
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DR EMBL; MG592473; AUR87453.1; -; Genomic_DNA.
DR Proteomes; UP000273409; Genome.
DR GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro.
DR CDD; cd00209; DHFR; 1.
DR Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR InterPro; IPR012259; DHFR.
DR InterPro; IPR024072; DHFR-like_dom_sf.
DR InterPro; IPR017925; DHFR_CS.
DR InterPro; IPR001796; DHFR_dom.
DR PANTHER; PTHR48069; DIHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR48069:SF3; DIHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF00186; DHFR_1; 1.
DR PRINTS; PR00070; DHFR.
DR SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR PROSITE; PS00075; DHFR_1; 1.
DR PROSITE; PS51330; DHFR_2; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 2..177
FT /note="DHFR"
FT /evidence="ECO:0000259|PROSITE:PS51330"
SQ SEQUENCE 177 AA; 20457 MW; 0E272CCF02FBD7FC CRC64;
MTIKMILCTD LHGGIGKNNS LPWGNAYPED LQYFKEQTLN SNVIMGRKTF ESLPFKYGLP
NRSNIVITSQ WRELGSAEHM SNGVFHVGES YVTRKMKVLG KSIPFSDNTW IIGGKSVYEK
LLPYVDEIHH SFIVDKTYDC DTFINCDLWE GDGNWYLADY KELSDKVKVQ IYKRKQK
//
