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Database: UniProt
Entry: A0A2I8DGC3_9BURK
LinkDB: A0A2I8DGC3_9BURK
Original site: A0A2I8DGC3_9BURK 
ID   A0A2I8DGC3_9BURK        Unreviewed;       670 AA.
AC   A0A2I8DGC3;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE            EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE   AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE   AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE   AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE   AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN   ORFNames=C2U31_10055 {ECO:0000313|EMBL:AUT46300.1};
OS   Achromobacter sp. AONIH1.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Achromobacter.
OX   NCBI_TaxID=1758194 {ECO:0000313|EMBL:AUT46300.1, ECO:0000313|Proteomes:UP000236176};
RN   [1] {ECO:0000313|Proteomes:UP000236176}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AONIH1 {ECO:0000313|Proteomes:UP000236176};
RX   PubMed=29437920;
RG   NISC Comparative Sequencing Program;
RA   Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P.,
RA   Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J.,
RA   Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.;
RT   "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of
RT   Bacterial Plasmids Conferring Carbapenem Resistance.";
RL   MBio 9:e02011-e02017(2018).
RN   [2] {ECO:0000313|Proteomes:UP000236176}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AONIH1 {ECO:0000313|Proteomes:UP000236176};
RA   Segre J.A., Mullikin J.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC         passage and rejoining.; EC=5.6.2.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000213};
CC   -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC       {ECO:0000256|ARBA:ARBA00009446}.
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DR   EMBL; CP026124; AUT46300.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2I8DGC3; -.
DR   KEGG; achr:C2U31_10055; -.
DR   OrthoDB; 9803554at2; -.
DR   Proteomes; UP000236176; Chromosome.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00186; TOP1Ac; 1.
DR   CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR   Gene3D; 3.40.50.140; -; 1.
DR   Gene3D; 3.30.65.10; Bacterial Topoisomerase I, domain 1; 1.
DR   Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR   Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR   Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR   InterPro; IPR000380; Topo_IA.
DR   InterPro; IPR003601; Topo_IA_2.
DR   InterPro; IPR023406; Topo_IA_AS.
DR   InterPro; IPR013497; Topo_IA_cen.
DR   InterPro; IPR013824; Topo_IA_cen_sub1.
DR   InterPro; IPR013825; Topo_IA_cen_sub2.
DR   InterPro; IPR013826; Topo_IA_cen_sub3.
DR   InterPro; IPR023405; Topo_IA_core_domain.
DR   InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR   InterPro; IPR013498; Topo_IA_Znf.
DR   InterPro; IPR005738; TopoIII.
DR   InterPro; IPR006171; TOPRIM_domain.
DR   InterPro; IPR034144; TOPRIM_TopoIII.
DR   NCBIfam; TIGR01056; topB; 1.
DR   PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR   PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR   Pfam; PF01131; Topoisom_bac; 1.
DR   Pfam; PF01751; Toprim; 1.
DR   Pfam; PF01396; zf-C4_Topoisom; 1.
DR   PRINTS; PR00417; PRTPISMRASEI.
DR   SMART; SM00437; TOP1Ac; 1.
DR   SMART; SM00436; TOP1Bc; 1.
DR   SMART; SM00493; TOPRIM; 1.
DR   SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR   SUPFAM; SSF57783; Zinc beta-ribbon; 1.
DR   PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
DR   PROSITE; PS50880; TOPRIM; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:AUT46300.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000236176};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          1..132
FT                   /note="Toprim"
FT                   /evidence="ECO:0000259|PROSITE:PS50880"
FT   REGION          646..670
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   670 AA;  72722 MW;  26F7D5AD009173C9 CRC64;
     MRLFLCEKPS QGKDIGRILG ATQRGEGCLS GSGVTVTWCI GHLVEAADPE VYDATLKRWS
     LEQLPIVPQQ WRVEVKPKTA TQFKVVKALL AKATHLVIAT DADREGELIA REIIDLCGYR
     GPIERLWLSA LNDASIRTAL GKLRPSSDTL PMYYSALARS RADWLVGMNL SRLFTVLGRQ
     AGYDGVLSVG RVQTPTLKLV VDRDREIAAF KSVPFWAIDV SLSAGGQAFS AQWVPPDGCT
     DDAGRCLQQP IAQQAAQQIR AAGSAQVVLV ETERVREGPP LLFDLGTLQE VCSKQLGLDV
     QETLEIAQAL YETHKATTYP RSDSGYLPES MFAEVPTVLD SLLKTDPSLR PIMGQLDRSQ
     RSRAWNDGKV TAHHGIIPTL EPANLSAMSE KELAVYRLIR AHYLAQFLPH HEFDRTVAEL
     SCGQQKLAAT GKQVVVKGWR LVLAERQADE DGDAAARSQV LPPLRQGMAC QVAEAEIKAL
     KTMPPKPYTQ GELVKSMKGV AKLVTDPRLK QKLKDTVGIG TEATRANIIS GLITRGYIVK
     KGRSIRASDA AFTLIDAVPA AIADPGTTAV WEQALDMIEA GQLTLDVFIG KQAAWISQLI
     AQYGSTSLSI KVPQGPACPQ CGAPTRQRTG KTGPFWSCSR YPDCKGTLPV DSGASKRGAS
     RPRSSGRKGS
//
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