ID A0A2I8VNN4_9EURY Unreviewed; 459 AA.
AC A0A2I8VNN4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase {ECO:0000313|EMBL:AUV82719.1};
GN Name=thiD {ECO:0000313|EMBL:AUV82719.1};
GN ORFNames=C2R22_14585 {ECO:0000313|EMBL:AUV82719.1};
OS Salinigranum rubrum.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Halorubraceae; Salinigranum.
OX NCBI_TaxID=755307 {ECO:0000313|EMBL:AUV82719.1, ECO:0000313|Proteomes:UP000236584};
RN [1] {ECO:0000313|EMBL:AUV82719.1, ECO:0000313|Proteomes:UP000236584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GX10 {ECO:0000313|EMBL:AUV82719.1,
RC ECO:0000313|Proteomes:UP000236584};
RA Han S.;
RT "Complete genome sequence of Salinigranum rubrum GX10T, an extremely
RT halophilic archaeon isolated from a marine solar saltern.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP026309; AUV82719.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2I8VNN4; -.
DR KEGG; srub:C2R22_14585; -.
DR OrthoDB; 43786at2157; -.
DR Proteomes; UP000236584; Chromosome.
DR GO; GO:0008972; F:phosphomethylpyrimidine kinase activity; IEA:InterPro.
DR GO; GO:0004789; F:thiamine-phosphate diphosphorylase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR CDD; cd01169; HMPP_kinase; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR Gene3D; 3.40.225.10; Class II aldolase/adducin N-terminal domain; 1.
DR InterPro; IPR036409; Aldolase_II/adducin_N_sf.
DR InterPro; IPR004399; HMP/HMP-P_kinase_dom.
DR InterPro; IPR013749; PM/HMP-P_kinase-1.
DR InterPro; IPR029056; Ribokinase-like.
DR InterPro; IPR019293; ThiN.
DR NCBIfam; TIGR00097; HMP-P_kinase; 1.
DR PANTHER; PTHR20858:SF17; HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED; 1.
DR PANTHER; PTHR20858; PHOSPHOMETHYLPYRIMIDINE KINASE; 1.
DR Pfam; PF08543; Phos_pyr_kin; 1.
DR Pfam; PF10120; ThiP_synth; 1.
DR SUPFAM; SSF53639; AraD/HMP-PK domain-like; 1.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:AUV82719.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000236584};
KW Transferase {ECO:0000313|EMBL:AUV82719.1}.
FT DOMAIN 20..262
FT /note="Pyridoxamine kinase/Phosphomethylpyrimidine kinase"
FT /evidence="ECO:0000259|Pfam:PF08543"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 406..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 459 AA; 48048 MW; 6F7F59B9283259D9 CRC64;
MSRRAVPDRR PVALTVAGSD SGGGAGIQAD LKTMEAHGVF GTSAITSVTA QHTRGVESTH
VLPVEEVDAQ LTAVRGDFDV AAVKTGMLAT TPVVERVTTR LGEWEVPSVV DPVMVATSGD
RLLEPEAEAA YEALVREATL VTPNADEAEV LTGVAVEDET AMREAGEALV EMGADAALVK
GGHVDTEGVI DLLVTEGASH RFESPRVDTA ATHGSGCTLS SAIAANLAGG ASLVEAVEAG
VTFMRRAVRY PLDVGEGPGS VHHLVALRDR AARHATSEAV EGVVDRLVGE EKSRVIVPEV
GLNVVGATPY AEETEDVAAV EGRITRTVGG VRPNRGVRFG ASSHVARFLL SVREFVPTYR
FAANCRYDAR VRAALDDLGW RVASFDRGNE PTPEEEASTM GWGAARAFET GDDGDGDEPP
VAVVDEGDVG KEPMTRVLAA DAETLGDRLL ELAAVTGEQ
//
