ID   A0A2I9CVZ7_9DEIO        Unreviewed;       813 AA.
AC   A0A2I9CVZ7;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Alpha-mannosidase {ECO:0000313|EMBL:GBF06144.1};
GN   ORFNames=DAERI_070142 {ECO:0000313|EMBL:GBF06144.1};
OS   Deinococcus aerius.
OC   Bacteria; Deinococcota; Deinococci; Deinococcales; Deinococcaceae;
OC   Deinococcus.
OX   NCBI_TaxID=200253 {ECO:0000313|EMBL:GBF06144.1, ECO:0000313|Proteomes:UP000236569};
RN   [1] {ECO:0000313|Proteomes:UP000236569}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TR0125 {ECO:0000313|Proteomes:UP000236569};
RA   Satoh K., Arai H., Sanzen T., Kawaguchi Y., Hayashi H., Yokobori S.,
RA   Yamagishi A., Oono Y., Narumi I.;
RT   "Draft Genome Sequence of the Radioresistant Bacterium Deinococcus aerius
RT   TR0125, Isolated from the Higher Atmosphere above Japan.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GBF06144.1}.
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DR   EMBL; BFAG01000007; GBF06144.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2I9CVZ7; -.
DR   OrthoDB; 9772207at2; -.
DR   Proteomes; UP000236569; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   CDD; cd10789; GH38N_AMII_ER_cytosolic; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR041147; GH38_C.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR   PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF17677; Glyco_hydro38C2; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT   DOMAIN          268..347
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   813 AA;  90985 MW;  804B802342BD1CF7 CRC64;
     MTTDVTHAVF HMIGNGHIDP VWLWNWPEGF QEIKATYRSA LDRLSEHPDF IFTCSSAGHL
     AWIEANEPEM FAEIQARVRE GRWALVGGWW VQPDCNLPGG ESFVRQGLYG QRFFQSRFGR
     TADTGYNPDS FGHAGTLPQI LLKSGLTRYT FMRPGPHEQA LPGRLFWWEG PDGSRVLTFR
     IPYEYCTWGK DLEAHVRKCM TELGQPVDEL MCFYGVGNHG GGPTRENLAS IARMNGEEDL
     PELRFSDPSR YFDAVQGRRV PVWTDELQHH AVGCYAAHSG VKRWNRQAEL ALVRAEKLAT
     LATAVTGLPY PGADLERAWK RVLFNQFHDI LAGSSIESAY EDARHEYGEA LATAQHVTNA
     AALRLSWRVS IPQREGSKPY VVFNPHAFPV RLPVEHETGG VPESFTVTDE GGRPIPAQRI
     RSEATVTGWR KRLTWLVDLP PLGYRTYTIL PGAAPEFPAV EASDTHLENA AYRLDMDPQT
     GGIARLLDKR GEVDVFRDTA AVGLVLRDDS DTWSHGVFRY GDPVGRFADA TCTLVERGPV
     RSTVRAVSRY GGSTLTQEFS LFADQPYVEV RVRVDWHERH RVLKLHFPAH LLAPQATFEA
     PYGVTTRPTD GSEEPGQRWV DLSGVFRPTG AVRGLTLVND AKSSYDTLDT NIRLTVLRSP
     IIAHHDPYVP SQDGDYRFLD QGEQTFTYWL YPHEGTWREA GVPRLAATLT ERPVIIPETY
     HPGPLDPAGS FLSAEPENVQ VTVLKRAEDG RGHVLRLVET HGQPTRAHLT LPFLGRELRT
     PLGAYEIKTL LIPDGDGPVL TLNLTELETL GEA
//