ID A0A2J6JMB8_LACSA Unreviewed; 700 AA.
AC A0A2J6JMB8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Acetyl-coenzyme A synthetase {ECO:0000256|RuleBase:RU361147};
DE EC=6.2.1.1 {ECO:0000256|RuleBase:RU361147};
GN ORFNames=LSAT_3X105260 {ECO:0000313|EMBL:PLY63960.1};
OS Lactuca sativa (Garden lettuce).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC Lactucinae; Lactuca.
OX NCBI_TaxID=4236 {ECO:0000313|EMBL:PLY63960.1};
RN [1] {ECO:0000313|EMBL:PLY63960.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28401891; DOI=10.1038/ncomms14953;
RA Reyes-Chin-Wo S., Wang Z., Yang X., Kozik A., Arikit S., Song C., Xia L.,
RA Froenicke L., Lavelle D.O., Truco M.J., Xia R., Zhu S., Xu C., Xu H.,
RA Xu X., Cox K., Korf I., Meyers B.C., Michelmore R.W.;
RT "Genome assembly with in vitro proximity ligation data and whole-genome
RT triplication in lettuce.";
RL Nat. Commun. 8:14953-14953(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate;
CC Xref=Rhea:RHEA:23176, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:456215; EC=6.2.1.1;
CC Evidence={ECO:0000256|RuleBase:RU361147};
CC -!- PATHWAY: Phytoalexin biosynthesis; 3,4',5-trihydroxystilbene
CC biosynthesis; 3,4',5-trihydroxystilbene from trans-4-coumarate: step
CC 1/2. {ECO:0000256|ARBA:ARBA00004930}.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|RuleBase:RU361147}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLY63960.1}.
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DR EMBL; NBSK01010807; PLY63960.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2J6JMB8; -.
DR STRING; 4236.A0A2J6JMB8; -.
DR EnsemblPlants; rna-gnl|WGS:NBSK|LSAT_3X105260_mrna; cds-PLY63960.1; gene-LSAT_3X105260.
DR Gramene; rna-gnl|WGS:NBSK|LSAT_3X105260_mrna; cds-PLY63960.1; gene-LSAT_3X105260.
DR OrthoDB; 144557at2759; -.
DR UniPathway; UPA00372; UER00547.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IBA:GO_Central.
DR GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006085; P:acetyl-CoA biosynthetic process; IBA:GO_Central.
DR GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR GO; GO:0009698; P:phenylpropanoid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd05966; ACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR011904; Ac_CoA_lig.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU361147};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU361147};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU361147};
KW Phenylpropanoid metabolism {ECO:0000256|ARBA:ARBA00023051}.
FT DOMAIN 67..127
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 135..522
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 584..662
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 700 AA; 78193 MW; DE820FF2CC7FE294 CRC64;
MAARKNLTTT NHLRHLESMA THPSGAGKIP RLNAVILGES LASEEDDLVF PSHDFSQQAH
VPSPQKYLEM YNRSIVDPGG FWSDIASEFY WKEKWGQQVY SENLDVTKGK IKIEWFKGGI
TNICYNCLDK NVESGNGDKV ALHWEGNEPD VDGSLTYRQL FEKVCQLANF LKDNGVKKGD
TVIIYLPMLM ELPITMLACA RIGAIHSVVF AGYSAESLLQ RIMDCKPKIV VTCNAVKRGK
KVLNLKEIVD AALSESSQNG ISVDSCLTYE NESAMKKEDT KWQKGRDIWW QDVVPKYPTT
CDVVWVDAED PLFLLYTSGS TGKPKGVLHT TGGYMIYTAT TFKYAFDYKE SDVYWCTADC
GWITGHSYVT YGPLLNGATV ILYEGVPNYP DSGRCWEIVD KYKVTIFYTA PTLVRSLMRD
GNEYVTRYSR KSLRVLGSVG EPINPSAWRW FFNVVGDSRC PISDTWWQTE TGGFMITPLP
GAWAQKPGSA TFPFFGVEPV IVDEKGKEIE GECSGYLCVK SSWPGAFRTL YGDHDRYETT
YFKPFPGYYF SGDGCSRDKN GYYWLTGRVD DVINVSGHRI GTAEVESALV SHPQCAEAAV
VGVEHEVKGQ GIYAFVTLVE GVPYSEDLRK SLVLVVRNQI GAFAAPDRIH WAPSLPKTRS
GKIMRRILRK IASRQLDELG DISTLADPSV VDQLIALADS
//
