ID A0A2J6JNW8_LACSA Unreviewed; 610 AA.
AC A0A2J6JNW8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Sodium/calcium exchanger membrane region domain-containing protein {ECO:0000259|Pfam:PF01699};
GN ORFNames=LSAT_8X85581 {ECO:0000313|EMBL:PLY64509.1};
OS Lactuca sativa (Garden lettuce).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC Lactucinae; Lactuca.
OX NCBI_TaxID=4236 {ECO:0000313|EMBL:PLY64509.1};
RN [1] {ECO:0000313|EMBL:PLY64509.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28401891; DOI=10.1038/ncomms14953;
RA Reyes-Chin-Wo S., Wang Z., Yang X., Kozik A., Arikit S., Song C., Xia L.,
RA Froenicke L., Lavelle D.O., Truco M.J., Xia R., Zhu S., Xu C., Xu H.,
RA Xu X., Cox K., Korf I., Meyers B.C., Michelmore R.W.;
RT "Genome assembly with in vitro proximity ligation data and whole-genome
RT triplication in lettuce.";
RL Nat. Commun. 8:14953-14953(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. Cation/calcium exchanger (CCX) subfamily.
CC {ECO:0000256|ARBA:ARBA00038187}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLY64509.1}.
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DR EMBL; NBSK01010574; PLY64509.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2J6JNW8; -.
DR EnsemblPlants; rna-gnl|WGS:NBSK|LSAT_8X85581_mrna; cds-PLY64509.1; gene-LSAT_8X85581.
DR Gramene; rna-gnl|WGS:NBSK|LSAT_8X85581_mrna; cds-PLY64509.1; gene-LSAT_8X85581.
DR OrthoDB; 3087817at2759; -.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006812; P:monoatomic cation transport; IBA:GO_Central.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR PANTHER; PTHR12266:SF18; CATION_CALCIUM EXCHANGER 2; 1.
DR PANTHER; PTHR12266; NA+/CA2+ K+ INDEPENDENT EXCHANGER; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 103..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 410..431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 440..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 466..488
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 550..568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 580..599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 110..253
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 445..595
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
SQ SEQUENCE 610 AA; 66592 MW; 8697DD5FBE03893E CRC64;
MDHRFRIPFN SRGSLHGVFS LVFLVFCFHQ QTHKWNYKVI NRVGLHSTPR NLGIKTPPDC
TGLNQHEGYE SVCEFLLANP QCKSDGFFNY MNFFYCSCQN HAFFGYIVLV LWLAALFYLL
GNTAADYFCC SLEKLSNLLR LPPTVAGVTL LPLGNGAPDV FASIAAFVGT DNGDVGLNSI
LGGAIFVTCV VVGTISICVA DQAVNIDKKC FIRDVSVFLF AVVSLAFILL IGEVSVGGAI
AFVFIYIVYA ALVAANEFLR LRDGILNIET ISVPLLAVTQ MDDYENKDLE SINMSFTDSD
DVPLLIESKV PHWMWGSNVS IYSEVLGHME DNPKPLWGWK DEEHNNSPLS CSKLFSCLEF
PLSLPRRLTI PIIEEGRWSK GYAVVSVTLA PSLLAFLWNN QYGNNRLATG LIYLACAVVG
CFLGGVAFIF INTNHPPQKW VLPWVVGGFF MSIVWFYMIA NELVSLLVAF GLIFGINPSI
LGLTLLAWGN SMGDLMSNVA LAVNGGEGVQ IAISGCYAGP MFNTLAGLGI CMLIGSWSNR
PESYKMGGDV GMFCNIGFLV VGLVWSLVVL PRNGMQPSKL LGIGLMGIYV VFLGTRLGMS
IGDGSLDNTG
//
