ID A0A2J6JTJ9_LACSA Unreviewed; 350 AA.
AC A0A2J6JTJ9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Cysteine protease {ECO:0008006|Google:ProtNLM};
GN ORFNames=LSAT_7X22980 {ECO:0000313|EMBL:PLY66117.1};
OS Lactuca sativa (Garden lettuce).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC Lactucinae; Lactuca.
OX NCBI_TaxID=4236 {ECO:0000313|EMBL:PLY66117.1};
RN [1] {ECO:0000313|EMBL:PLY66117.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28401891; DOI=10.1038/ncomms14953;
RA Reyes-Chin-Wo S., Wang Z., Yang X., Kozik A., Arikit S., Song C., Xia L.,
RA Froenicke L., Lavelle D.O., Truco M.J., Xia R., Zhu S., Xu C., Xu H.,
RA Xu X., Cox K., Korf I., Meyers B.C., Michelmore R.W.;
RT "Genome assembly with in vitro proximity ligation data and whole-genome
RT triplication in lettuce.";
RL Nat. Commun. 8:14953-14953(2017).
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLY66117.1}.
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DR EMBL; NBSK01010015; PLY66117.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2J6JTJ9; -.
DR STRING; 4236.A0A2J6JTJ9; -.
DR EnsemblPlants; rna-gnl|WGS:NBSK|LSAT_7X22980_mrna; cds-PLY66117.1; gene-LSAT_7X22980.
DR Gramene; rna-gnl|WGS:NBSK|LSAT_7X22980_mrna; cds-PLY66117.1; gene-LSAT_7X22980.
DR OrthoDB; 5472443at2759; -.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IBA:GO_Central.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF944; SENESCENCE-SPECIFIC CYSTEINE PROTEASE SAG39; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..350
FT /note="Cysteine protease"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018547757"
FT DOMAIN 42..99
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 129..346
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 350 AA; 38268 MW; 6A399F10F3C51D24 CRC64;
MANSHQKGST LVMTLALLML LVAMASRATS RTLNDPTMIA RHEQWMAHHG RIYTDENEKQ
LRFQIFKNNV AYIDAHNARS DQSYTLEVNK FADLTNDEFR ASRNGYKKQP DSDSHVVSGL
FRYANVSAVP DEVDWRKEGA VTPVKDQGDC GCCWAFSAVA AMEGINKLEN GKLVSLSEQE
LVDCDIDGID QGCEGGLMEN AFQFIEKRKG LAAESVYPYT GEDGICNTKK AAIPAAKISG
HEKVPANNEK ALLQAVANQP VSIAIDASGY EFQFYSGGVF TGSCGTELDH AITAVGYGAT
MDGTKYWLMK NSWGASWGEK GYIRIKRDSL AKEGLCGIAM DPSYPVVSKA
//
