ID A0A2J6K4S5_LACSA Unreviewed; 501 AA.
AC A0A2J6K4S5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Cytochrome P450 {ECO:0008006|Google:ProtNLM};
GN ORFNames=LSAT_4X115101 {ECO:0000313|EMBL:PLY70084.1};
OS Lactuca sativa (Garden lettuce).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC Lactucinae; Lactuca.
OX NCBI_TaxID=4236 {ECO:0000313|EMBL:PLY70084.1};
RN [1] {ECO:0000313|EMBL:PLY70084.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28401891; DOI=10.1038/ncomms14953;
RA Reyes-Chin-Wo S., Wang Z., Yang X., Kozik A., Arikit S., Song C., Xia L.,
RA Froenicke L., Lavelle D.O., Truco M.J., Xia R., Zhu S., Xu C., Xu H.,
RA Xu X., Cox K., Korf I., Meyers B.C., Michelmore R.W.;
RT "Genome assembly with in vitro proximity ligation data and whole-genome
RT triplication in lettuce.";
RL Nat. Commun. 8:14953-14953(2017).
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLY70084.1}.
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DR EMBL; NBSK01008663; PLY70084.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2J6K4S5; -.
DR EnsemblPlants; rna-gnl|WGS:NBSK|LSAT_4X115101_mrna; cds-PLY70084.1; gene-LSAT_4X115101.
DR Gramene; rna-gnl|WGS:NBSK|LSAT_4X115101_mrna; cds-PLY70084.1; gene-LSAT_4X115101.
DR OrthoDB; 2251108at2759; -.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR GO; GO:0019438; P:aromatic compound biosynthetic process; IEA:UniProt.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR CDD; cd11072; CYP71-like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR47956; CYTOCHROME P450 71B11-RELATED; 1.
DR PANTHER; PTHR47956:SF49; CYTOCHROME P450 83B1; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|RuleBase:RU000461}; Iron {ECO:0000256|RuleBase:RU000461};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU000461}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..501
FT /note="Cytochrome P450"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014428049"
SQ SEQUENCE 501 AA; 57473 MW; DB204DDB1729FAB9 CRC64;
MALFFLCLLV CVPLLSLLYL LSKIIKNRSC SYPPGPHGLP FIGNLHQIDY SSLHTFLWQL
SKSYGPVISL QFGFIPAIVV SSANVAKEVL KTQDIIFCNR PSFVGSKKLS YNGLDVTFSP
YNDYWRDMRK VYMFHLLSPK KVESFRYIRE DEVSSTMKKI YEQALSSKMV NLSETMKHVA
ITLVTRVGFG KSYQDEHERK NVLRLLNELQ SITAEFFVSD LWPGLPFVGL VDRFLGKMDR
VEKCFKSLDS FYEELIGEHL DPQNRKSNEE EEDIVDILLR LKKDKDFNFT YDHIKGMLVD
ILVAGTDTSA ATVIWAMTSL VSDPRVMKKT QEEVRNVVGK KGRVDEDDLS KLTYLKAVVK
ETLRLYPPAP LLVPRESQKD VILHGYKIKK KTIVYVNAFA IGRDPEAWEN PEKFIPERFL
CSDIDFRGNN FEFIPFGAGR RICPGMSMGV VTVELLIANL VYLFDWALPD GMKKEDLDFE
AMEGITMHKR NDLCLVAHMY L
//
