ID A0A2J6K9U8_LACSA Unreviewed; 382 AA.
AC A0A2J6K9U8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Chalcone synthase {ECO:0008006|Google:ProtNLM};
GN ORFNames=LSAT_3X45501 {ECO:0000313|EMBL:PLY71851.1};
OS Lactuca sativa (Garden lettuce).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC Lactucinae; Lactuca.
OX NCBI_TaxID=4236 {ECO:0000313|EMBL:PLY71851.1};
RN [1] {ECO:0000313|EMBL:PLY71851.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28401891; DOI=10.1038/ncomms14953;
RA Reyes-Chin-Wo S., Wang Z., Yang X., Kozik A., Arikit S., Song C., Xia L.,
RA Froenicke L., Lavelle D.O., Truco M.J., Xia R., Zhu S., Xu C., Xu H.,
RA Xu X., Cox K., Korf I., Meyers B.C., Michelmore R.W.;
RT "Genome assembly with in vitro proximity ligation data and whole-genome
RT triplication in lettuce.";
RL Nat. Commun. 8:14953-14953(2017).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531,
CC ECO:0000256|RuleBase:RU003633}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLY71851.1}.
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DR EMBL; NBSK01008175; PLY71851.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2J6K9U8; -.
DR STRING; 4236.A0A2J6K9U8; -.
DR EnsemblPlants; rna-gnl|WGS:NBSK|LSAT_3X45501_mrna; cds-PLY71851.1; gene-LSAT_3X45501.
DR Gramene; rna-gnl|WGS:NBSK|LSAT_3X45501_mrna; cds-PLY71851.1; gene-LSAT_3X45501.
DR OrthoDB; 883077at2759; -.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IBA:GO_Central.
DR GO; GO:0030639; P:polyketide biosynthetic process; IBA:GO_Central.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR PANTHER; PTHR11877:SF10; TYPE III POLYKETIDE SYNTHASE B; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003633};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003633}.
FT DOMAIN 4..220
FT /note="Chalcone/stilbene synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00195"
FT DOMAIN 229..380
FT /note="Chalcone/stilbene synthase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02797"
FT ACT_SITE 156
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000451-1"
SQ SEQUENCE 382 AA; 41620 MW; 5FB0CFE24EA1DF4C CRC64;
MTTKSSVGKA NILALGKAFP HQLVMQDLLV EGYFKDTHCD DPELKQKLTR LCKTTCVKTR
YVVMSQEILE KYPELALEGL PTVRQRLEIA NKAVTQMAIE ASQACIKKWA RPISDITHLV
YVSSSEARLP GGDIYLAKGL GLSPNTNRVL LYFSGCSGGV AGLRVAKDIA ENNPGSRVLL
ATAETTIVGY KPPNVNRPYD LVGVALFGDG AGAMMIGSDP TGPESPLFEL HTAIQNFLPD
TEKVIDGRLS EEGISFRLDR DLPEIIEDNV KGFCDKLMGY YGPNEMAYND LFWAVHPGGP
AILNKLEKKL DLLPDKLNAS RKALADYGNA SSNTIVYVLE YLIEEGLKRK KEGKDGGPDL
GLILAFGPGV TFEGILTKNL TV
//
