ID A0A2J6KDL7_LACSA Unreviewed; 158 AA.
AC A0A2J6KDL7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=H/ACA ribonucleoprotein complex subunit 2 {ECO:0000256|RuleBase:RU366039};
DE AltName: Full=Nucleolar protein family A member 2 {ECO:0000256|RuleBase:RU366039};
GN ORFNames=LSAT_2X112741 {ECO:0000313|EMBL:PLY73153.1};
OS Lactuca sativa (Garden lettuce).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC Lactucinae; Lactuca.
OX NCBI_TaxID=4236 {ECO:0000313|EMBL:PLY73153.1};
RN [1] {ECO:0000313|EMBL:PLY73153.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28401891; DOI=10.1038/ncomms14953;
RA Reyes-Chin-Wo S., Wang Z., Yang X., Kozik A., Arikit S., Song C., Xia L.,
RA Froenicke L., Lavelle D.O., Truco M.J., Xia R., Zhu S., Xu C., Xu H.,
RA Xu X., Cox K., Korf I., Meyers B.C., Michelmore R.W.;
RT "Genome assembly with in vitro proximity ligation data and whole-genome
RT triplication in lettuce.";
RL Nat. Commun. 8:14953-14953(2017).
CC -!- FUNCTION: Common component of the spliceosome and rRNA processing
CC machinery. {ECO:0000256|RuleBase:RU366039}.
CC -!- FUNCTION: Required for ribosome biogenesis. Part of a complex which
CC catalyzes pseudouridylation of rRNA. This involves the isomerization of
CC uridine such that the ribose is subsequently attached to C5, instead of
CC the normal N1. Pseudouridine ('psi') residues may serve to stabilize
CC the conformation of rRNAs. {ECO:0000256|RuleBase:RU366039}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604, ECO:0000256|RuleBase:RU366039}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL8 family.
CC {ECO:0000256|ARBA:ARBA00007337, ECO:0000256|RuleBase:RU366039}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLY73153.1}.
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DR EMBL; NBSK01007839; PLY73153.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2J6KDL7; -.
DR STRING; 4236.A0A2J6KDL7; -.
DR EnsemblPlants; rna-gnl|WGS:NBSK|LSAT_2X112741_mrna; cds-PLY73153.1; gene-LSAT_2X112741.
DR Gramene; rna-gnl|WGS:NBSK|LSAT_2X112741_mrna; cds-PLY73153.1; gene-LSAT_2X112741.
DR OrthoDB; 5481356at2759; -.
DR GO; GO:0031429; C:box H/ACA snoRNP complex; IBA:GO_Central.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0034513; F:box H/ACA snoRNA binding; IBA:GO_Central.
DR GO; GO:0000470; P:maturation of LSU-rRNA; IBA:GO_Central.
DR GO; GO:0031118; P:rRNA pseudouridine synthesis; IBA:GO_Central.
DR GO; GO:0031120; P:snRNA pseudouridine synthesis; IBA:GO_Central.
DR Gene3D; 3.30.1330.30; -; 1.
DR InterPro; IPR002415; H/ACA_rnp_Nhp2-like.
DR InterPro; IPR029064; Ribosomal_eL30-like_sf.
DR InterPro; IPR004038; Ribosomal_eL8/eL30/eS12/Gad45.
DR InterPro; IPR018492; Ribosomal_eL8/Nhp2.
DR PANTHER; PTHR23105:SF197; RIBONUCLOPROTEIN; 1.
DR PANTHER; PTHR23105; RIBOSOMAL PROTEIN L7AE FAMILY MEMBER; 1.
DR Pfam; PF01248; Ribosomal_L7Ae; 1.
DR PRINTS; PR00881; L7ARS6FAMILY.
DR PRINTS; PR00883; NUCLEARHMG.
DR SUPFAM; SSF55315; L30e-like; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU366039};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274,
KW ECO:0000256|RuleBase:RU366039};
KW RNA-binding {ECO:0000256|RuleBase:RU366039}.
FT DOMAIN 41..124
FT /note="Ribosomal protein eL8/eL30/eS12/Gadd45"
FT /evidence="ECO:0000259|Pfam:PF01248"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 158 AA; 17189 MW; C5D267851F52FBF6 CRC64;
MGGSDSEVEK SAHKEKEKKK LQALAPIAKP LAGKKLSKRT LKLVRKAAEH KCLKRGVKEV
VKSIRRGNKG VCVIAGNITP IDVITHVPIL CEEAEIPYVY VTSKEDLANA GATKRPTCCV
LVLPKPTKGE LGEEIQQKLK TEYDEVATEI TSLAASLF
//
