ID A0A2J6KE85_LACSA Unreviewed; 1012 AA.
AC A0A2J6KE85;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=LSAT_6X70541 {ECO:0000313|EMBL:PLY73388.1};
OS Lactuca sativa (Garden lettuce).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC Lactucinae; Lactuca.
OX NCBI_TaxID=4236 {ECO:0000313|EMBL:PLY73388.1};
RN [1] {ECO:0000313|EMBL:PLY73388.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28401891; DOI=10.1038/ncomms14953;
RA Reyes-Chin-Wo S., Wang Z., Yang X., Kozik A., Arikit S., Song C., Xia L.,
RA Froenicke L., Lavelle D.O., Truco M.J., Xia R., Zhu S., Xu C., Xu H.,
RA Xu X., Cox K., Korf I., Meyers B.C., Michelmore R.W.;
RT "Genome assembly with in vitro proximity ligation data and whole-genome
RT triplication in lettuce.";
RL Nat. Commun. 8:14953-14953(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLY73388.1}.
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DR EMBL; NBSK01007690; PLY73388.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2J6KE85; -.
DR STRING; 4236.A0A2J6KE85; -.
DR EnsemblPlants; rna-gnl|WGS:NBSK|LSAT_6X70541_mrna; cds-PLY73388.1; gene-LSAT_6X70541.
DR Gramene; rna-gnl|WGS:NBSK|LSAT_6X70541_mrna; cds-PLY73388.1; gene-LSAT_6X70541.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 687..1012
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 996
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1012 AA; 115867 MW; 99C36B8A7BF126B3 CRC64;
MFFSGDPSNR KRVDLGGRSS KERDRKKLLE QAKLERNKRS QQRQQNSAAL TIQKCFRGRK
VVKLERGSAR ERFYTTYGKH CERVDRQCFG PDSEFLRELL YFLSPRNASD ISTLVEACRL
FSQFAKESGD ILNLFGGSHY SSDHALVNYR VKKLAYVCIQ AIHHNRHQLK DQLLSTSLDS
NTPTSILLKA AALLIDPKLP WSCKIASYLL QQNIYKIFRE IVITGRESLN SESRIGNVSL
MERVLAQVVT HTGQGHCVCP DIDLQWSFAS QILTIPFLWQ IFPHLKETYV SQGLCQYYLH
KMATCSQNYE KVLPVDISSE FPGYACLLGN LLESVGVALS RPSCSYNMTI DFATVATLLL
EALPPIQTSS TGNREENSIM GDDDMIIDDG SVVVPLNKEL EKQISNAIDP RFLLQLTNIL
LGGSSSKDKI KDTEAAAVGA ACSFLHVTFT IFPLERIMTV LAYRTELVSV LWSFMKRCYE
SQNWSSLSAM SAYLPGDAFG WLLPMAVFCP VYRHMLTIVD NEEFYEQEKP LSLKDIRLLI
VILRQSLWQI LWLNPVAPMK FTKINLSLKK HRVEFVQYRV SVVASELLSQ LQDWNNRRQF
AHPSNFHADG VNDHFISQAM IENTRAYDIL KQAPFLVPFT SRVKLFTSQL AAIKERLGSH
SLFNRSTFKI RRDHILEDAF NQLSTLSEED LRGVIRVTFV NEFGVEEAGI DGGGIFKDFM
ENITRAAFDM QYGLFKETID HLLYPNPGSG MIHEQHLQFF HFLGIILGKA MFEGILVDIP
FATFFLSKLK QKHNYLNDLP SLDPELYRHL IFLKRYEGDL SELELYFVIV NNEFGEQTSE
ELIPGGKNIR VVNDNVITFI HLVANHRLNT QIRLQSSHFL RGFQQLIQKD WIDMFNEHEL
QLLISGSVDG FDVDDLRSNT NYAGGYHREH YVIDMFWEIL KNFSLENQHK FLKFVTGCSR
GPLLGFKYLE PLFCIQRAAG SASEEALDRL PTSATCMNLL KLPPYRRFVI LF
//