ID A0A2J6KQC1_LACSA Unreviewed; 1041 AA.
AC A0A2J6KQC1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN ORFNames=LSAT_4X97440 {ECO:0000313|EMBL:PLY77270.1};
OS Lactuca sativa (Garden lettuce).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC Lactucinae; Lactuca.
OX NCBI_TaxID=4236 {ECO:0000313|EMBL:PLY77270.1};
RN [1] {ECO:0000313|EMBL:PLY77270.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28401891; DOI=10.1038/ncomms14953;
RA Reyes-Chin-Wo S., Wang Z., Yang X., Kozik A., Arikit S., Song C., Xia L.,
RA Froenicke L., Lavelle D.O., Truco M.J., Xia R., Zhu S., Xu C., Xu H.,
RA Xu X., Cox K., Korf I., Meyers B.C., Michelmore R.W.;
RT "Genome assembly with in vitro proximity ligation data and whole-genome
RT triplication in lettuce.";
RL Nat. Commun. 8:14953-14953(2017).
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLY77270.1}.
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DR EMBL; NBSK01006460; PLY77270.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2J6KQC1; -.
DR STRING; 4236.A0A2J6KQC1; -.
DR EnsemblPlants; rna-gnl|WGS:NBSK|LSAT_4X97440_mrna; cds-PLY77270.1; gene-LSAT_4X97440.
DR Gramene; rna-gnl|WGS:NBSK|LSAT_4X97440_mrna; cds-PLY77270.1; gene-LSAT_4X97440.
DR OrthoDB; 38995at2759; -.
DR GO; GO:0097361; C:CIA complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IBA:GO_Central.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IBA:GO_Central.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR024687; MMS19_C.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 50..314
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT DOMAIN 661..990
FT /note="MMS19 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12460"
SQ SEQUENCE 1041 AA; 116894 MW; CDDEA3FE8D6F04B5 CRC64;
MGDSTTINCV KHIETYVDSS SSKSPAEQDA SLDAIAKLVM NDMITLESLV REMGMYLTTT
DNIIRARGIL LLAELLTRIS SKPLENATIH SLIGFFAERL SDWRALRGAL VGCLALMRRK
GDISSSDATA VAQSFMQNLQ VQSLGQHDRK LCFELLECLI DCYPNTVMTM EDDFVYVICE
AIDGEKDPQC LLLTFHLVEM LSHLYPDSSN SLTSYAEDLF NILGSYFPIH FTHPKGEDDV
KREELSRALM LAFASTPLFE PFSIPLLLEK LSSSLPSSKV ESLKYLSYCT LKYGPHRMLQ
HLESLWSSLK EAIFTSDQSN SNKIASEALV LLQNLIQQDN GVFVNLILKD ADINLTLNSL
SNYNNHDDSP MPDQQRLNSI GQILHVSSAA SMASCNAIFQ SFFSGLVNGL EKDYASEKPK
FGCLYICVEL LAACRILVMK NDEVSYNENE TWCIMLHSFC DSLISSFVKS IKESNEDSYT
QSGVRGLKIL ASFPGSFSPV SKSTFENILR EFISIIILKF NNTSLWSSIL DSLTEIGSFI
EKSQDSEKMP SFDAIIVDKM VDLLSSDDST MPFSLKVKSV SEIGLINLKY MMKIVQELNK
TIITSLHKSW IDGDSKSVEH AMILLECYDD KILPWFQNIK DSDDVATNFA LKIWDEIEDN
TLFYDTLVEK KLLETTMNTM KHAVATCSEE NQTKILEKSF KVNESNLVNK VSQPRNKWII
SLFNSVIIAL HPKTNIKNPK KTLETLIESL TNGHTSSAHA LGSFFNKIPS NEAIIDNTFS
HLIKFSNVNA IIGLSWMGKG LLMRGHEKVK DLIKFFLDFL ILNSPQDQEM VDLMRSVADS
FGIMMSDSEF CLNKRLNSVI KPLYKQRLFS IVMPILSSSI VKLDSPVTRS MQHRALAHVI
SNAPLSAVLG EAKKLIPLML DGLTILSEDV ENRDILYNLL LVLSGILTNK NGEEVIVENA
YIIIRCINKL VAYPHMMLVR ETAVQCLTAM SEVSYARVYP FRPEVLQALS RALDDPKRSV
RQEAVRCRQA WASVSSRSLH I
//