ID A0A2J6KXD4_LACSA Unreviewed; 859 AA.
AC A0A2J6KXD4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Glutamate receptor {ECO:0000256|PIRNR:PIRNR037090};
GN ORFNames=LSAT_5X128901 {ECO:0000313|EMBL:PLY79667.1};
OS Lactuca sativa (Garden lettuce).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC Lactucinae; Lactuca.
OX NCBI_TaxID=4236 {ECO:0000313|EMBL:PLY79667.1};
RN [1] {ECO:0000313|EMBL:PLY79667.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28401891; DOI=10.1038/ncomms14953;
RA Reyes-Chin-Wo S., Wang Z., Yang X., Kozik A., Arikit S., Song C., Xia L.,
RA Froenicke L., Lavelle D.O., Truco M.J., Xia R., Zhu S., Xu C., Xu H.,
RA Xu X., Cox K., Korf I., Meyers B.C., Michelmore R.W.;
RT "Genome assembly with in vitro proximity ligation data and whole-genome
RT triplication in lettuce.";
RL Nat. Commun. 8:14953-14953(2017).
CC -!- FUNCTION: Glutamate-gated receptor that probably acts as non-selective
CC cation channel. {ECO:0000256|PIRNR:PIRNR037090}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685, ECO:0000256|PIRNR:PIRNR037090}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLY79667.1}.
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DR EMBL; NBSK01005841; PLY79667.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2J6KXD4; -.
DR EnsemblPlants; rna-gnl|WGS:NBSK|LSAT_5X128901_mrna; cds-PLY79667.1; gene-LSAT_5X128901.
DR Gramene; rna-gnl|WGS:NBSK|LSAT_5X128901_mrna; cds-PLY79667.1; gene-LSAT_5X128901.
DR OrthoDB; 511851at2759; -.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR CDD; cd13686; GluR_Plant; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR017103; Iontropic_Glu_rcpt_pln.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966:SF584; IONOTROPIC GLUTAMATE RECEPTOR, METAZOA, PERIPLASMIC BINDING PROTEIN-LIKE I-RELATED; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF00497; SBP_bac_3; 2.
DR PIRSF; PIRSF037090; Iontro_Glu-like_rcpt_pln; 2.
DR SMART; SM00062; PBPb; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR037090-50};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|PIRNR:PIRNR037090};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|PIRNR:PIRNR037090};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|PIRNR:PIRNR037090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR037090};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037090};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR037090}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..859
FT /note="Glutamate receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014322002"
FT TRANSMEM 526..544
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 556..574
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 586..607
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 764..785
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 409..750
FT /note="Solute-binding protein family 3/N-terminal"
FT /evidence="ECO:0000259|SMART:SM00062"
FT DOMAIN 409..743
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DISULFID 691..746
FT /evidence="ECO:0000256|PIRSR:PIRSR037090-50"
SQ SEQUENCE 859 AA; 96471 MW; 0649370A332A2858 CRC64;
MLKTLFCLAF LSSCFLLQAK IIDGTSIGAI FDQTSRPGKE AKVAIEIAIQ DFNIKTNQTS
VLYLQNSRNK PGQAAIAAKH LIDEHKVKAI LGGHTWEEAS AIAEVISDCN HDFPVFLSLA
GTAPPQVPHQ WPFFVQAVPT ESTQMKAVAA VLQSLGMRKV TLIYETLPLA SSSASIISHL
SQAFRQTGSE LIHILPLASG SSFLDEELDV LKRQQRKVFV IHTSMELGIR LFQTAKKMEM
TGDGYLWIAT NGITDLFHSI NSTMITSLKG MVGVKSYFPE NTPEFQDFRK KFRHKFRSDY
PEEEKDEPGI FAVQGYNAVE LLEKNSPENF GHWRSIPATT VEIVNVIGKG YHSVYWTEGS
GFSETIEEDI NGATTYTHSI DNVGQALWPG QPWYANSRRR NLAESSENRI RVGVPGRSLF
NQFVKVDVNT GDITGFVVSV FEEVMRKMNQ SFDYIPFYGS YDQLIQQIPN KNFDAIAGDV
TILSDRHEFV DFTQPYTESG LEMIVPVRSR VSNQAWLFLK PFTPTMWWLI AGITLYNGFI
IWLIEKNYVK DLRGSIINQV GVIIWLSFST LFTLRGDKLH SNLSRMAAVV WLFVALIITQ
SYTASLASML TAERLEPTIS SVEMLRNMNA TVGYCNGSFV DRYLTGVLGF PNVKTNSYNS
THQYAEALNS GEIAAIFLEV PATKVFLAQY CRSFIRTGET FKVGGFGFAF PKEYDRLSEA
NEALMNVAES GRLKELEEVH IISEKCIDED SAPNEEDSLS ARSFWVLFVL TVGVSTVALV
IYIIIRIKEV KKSDEENKGF LELISTFFKD LKRQMKRSSS IVVNVESARH ASHGDRSAQD
DIDDIQETDD DSIFYEVRI
//
