ID A0A2J6L119_LACSA Unreviewed; 822 AA.
AC A0A2J6L119;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 13-SEP-2023, entry version 18.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN ORFNames=LSAT_9X107620 {ECO:0000313|EMBL:PLY81028.1};
OS Lactuca sativa (Garden lettuce).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC Lactucinae; Lactuca.
OX NCBI_TaxID=4236 {ECO:0000313|EMBL:PLY81028.1};
RN [1] {ECO:0000313|EMBL:PLY81028.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28401891; DOI=10.1038/ncomms14953;
RA Reyes-Chin-Wo S., Wang Z., Yang X., Kozik A., Arikit S., Song C., Xia L.,
RA Froenicke L., Lavelle D.O., Truco M.J., Xia R., Zhu S., Xu C., Xu H.,
RA Xu X., Cox K., Korf I., Meyers B.C., Michelmore R.W.;
RT "Genome assembly with in vitro proximity ligation data and whole-genome
RT triplication in lettuce.";
RL Nat. Commun. 8:14953-14953(2017).
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLY81028.1}.
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DR EMBL; NBSK01005436; PLY81028.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2J6L119; -.
DR STRING; 4236.A0A2J6L119; -.
DR EnsemblPlants; rna-gnl|WGS:NBSK|LSAT_9X107620_mrna; cds-PLY81028.1; gene-LSAT_9X107620.
DR Gramene; rna-gnl|WGS:NBSK|LSAT_9X107620_mrna; cds-PLY81028.1; gene-LSAT_9X107620.
DR OrthoDB; 1967517at2759; -.
DR GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF107; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 425..449
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 470..487
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 550..571
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 583..606
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 639..657
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 759..780
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT COILED 103..130
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 822 AA; 92391 MW; 55F4E8D7A397D6EB CRC64;
MAEHGGGGGC CPPMDLFRSE PMHLIQVIIP IESARLTVSY LGDIGLIQFK DLNVEKSPFQ
RTYAGQIKRC AELARKLRFF KDQMSKADII PSGKLDTKAG LNLDDLEVNL GDLEAELVEI
NANSEKLQRG YNELVEYKLV LQKAGEFFKV AQSSASEHQG EGSSHQGAEE SLETPLLNDQ
ESTVDQGKQV KLGYITGLVA KEKAMAFERI LFRATRGNVF LRQSSVDEAV TDPSSGEKVQ
KSVFVVFFSG ERAKSKILKI CEAFGANRYP FPEDLSKQAQ MITEVSGRLS ELKTTIDTGL
VHRTNLLETI AKQYEQWNDL VRKEKSIYHT LNMLSIDVTK KCLVAEGWSP IFATQQIQEA
LQQATIDAKS QVGAIFQVLH TKEMPPTYFR TNKFTESFQT IVDAYGVARY QEANPGVYTV
VTFPFLFAVM FGDWGHGICI LIAALFLILK EKKYSSQKLG DIMEMTFGGR YVIFLMALFS
IYTGLIYNEF FSVPFELFSP SAYACRDDAC SEATTIGLIK VGDTYPFGVD PVWHGSRSEL
PFLNSLKMKM SILLGVAQMN LGIVLSFFNA IYFKNSVNVW FQFIPQMIFL NGLFGYLSLL
IILKWITGSK ADLYHVMIYM FLSPTDDLAE NELFPNQKTV QLVLLLLSLI AVPWMLLPKP
FILKAQHNRT HQGDSYVALE GTDESLVEGG HHGSHDHEEE FEFSEVFVHQ LIHTIEFVLG
AVSNTASYLR LWALSLAHSE LSTVFYEKVL LLAWGYNNVI ILGVGIIVFV FATVGVLLVM
ETLSAFLHAL RLHWVEFQNK FYEGDGYKFA PFSFALLVNE DE
//
