ID A0A2J6L132_LACSA Unreviewed; 2004 AA.
AC A0A2J6L132;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 13-SEP-2023, entry version 21.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN ORFNames=LSAT_9X109381 {ECO:0000313|EMBL:PLY80974.1};
OS Lactuca sativa (Garden lettuce).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC Lactucinae; Lactuca.
OX NCBI_TaxID=4236 {ECO:0000313|EMBL:PLY80974.1};
RN [1] {ECO:0000313|EMBL:PLY80974.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28401891; DOI=10.1038/ncomms14953;
RA Reyes-Chin-Wo S., Wang Z., Yang X., Kozik A., Arikit S., Song C., Xia L.,
RA Froenicke L., Lavelle D.O., Truco M.J., Xia R., Zhu S., Xu C., Xu H.,
RA Xu X., Cox K., Korf I., Meyers B.C., Michelmore R.W.;
RT "Genome assembly with in vitro proximity ligation data and whole-genome
RT triplication in lettuce.";
RL Nat. Commun. 8:14953-14953(2017).
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLY80974.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NBSK01005436; PLY80974.1; -; Genomic_DNA.
DR STRING; 4236.A0A2J6L132; -.
DR EnsemblPlants; rna-gnl|WGS:NBSK|LSAT_9X109381_mrna; cds-PLY80974.1; gene-LSAT_9X109381.
DR Gramene; rna-gnl|WGS:NBSK|LSAT_9X109381_mrna; cds-PLY80974.1; gene-LSAT_9X109381.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004430; F:1-phosphatidylinositol 4-kinase activity; IBA:GO_Central.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IBA:GO_Central.
DR GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1457..1636
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1710..1988
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 187..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2004 AA; 221183 MW; 07EDA58A7357DF72 CRC64;
MEALTELCDL IAQNPNQFSD KIAWICSRCP PSESLLSGSP RISRSQLNAV LVTARFISKC
GNYSDTRPRT IALEFIRAIP ASFEQSFWPK SFGNSSIASF YAEFFGYVCK AAELYPEFDS
DVARFMGDIV FIAVNDRCGD IAISKAFLSV LSESFPPIIP SDANKLVTSL LDGLDFALPS
SSSPKAIMGS NSSSQSSPVS VSNVAASSSS NGGVDDANSK AIVTNGGTTG GWATIGTPSG
SDRRGAAYFE EELVENLEKQ EIAFKLIGHI LDKTQIDPKL LERLHIITKD QLKSISSFLK
IRKRDWSEQG SLLKARINTK LSVYKAAVKL KVRSLASLDS DGKSAKKLLH GALALLVEAA
EACVYSVWRK LRICEDLFSS LLDGISKIAV TRGGHLLRVL FIRFKPLVLT TCAQADTWAS
SQGAMFESVL KASCEIIDYG WTKDRAPVDT FIMGLATSIR ERNDYEEEDN AKEKQAVPIV
QLNVIRLLAE LNVQVKKTEV VDTILPLFIE SLEEGDASTP GLLRLRLLDA VSRIASLGFE
KSYREAVVLM IRSYLSKLST IGSAESRTLP PEANTERVEM LTGSITFKTL PAGFQSIAKG
LTNEKLRVDF RHRLLSLCSD VGLAAESKSG SSGADFLGPL LPAVAEICSD FDPTVDVEPS
LMKLFRNLWF YIALFGLAPP ILRSPVSVKP NSTTLNNGGN TTAVALQAVG GPYMWNPQWS
SAVQRISQGT PPLVVSSVKW LEDELELNAL HNPGSRRGNG NEKAAVNQRT ALSAALGGRV
EVGSMTTISG VKATYLLAVA FVEIIRFSSN GGILNHGPNS TASRSAFSCV FEYLKSPNLM
PAVLQCLMAI VHRAFETALS WLEAQICETG DAAEVRESTL AVHACFLIKS LSVREEHIRD
VSVNLLSQLR ERFPQILWKS SCLDSLLFSV NGDPPSSLVN DPASVASVRS LYQSVVKEWI
VDSLSYAPCT TQGLLQEQLC KANTWQKAQP TTDVVSLLSE IKIGTGKTDC WKGKKTANIP
AVMASAAAAS GGNLKSTEAF NIEVLSTAIV SATVKCNHAG EIAGMKRLYE NIDGADDDDD
DDKGSEVAPK KQSFGEILLN KFVRLLQKFV SMAEKGGSVD KSSFRETCSQ ATALLLSSLA
SDAKPNAESF SQLLRLLCWC PAYISTPDAM ETGIFIWTWL VSAAPELGCV VLAELVDAWL
WTIDTKRGLF ASQVRFHGPA AKLRPQLAPG EPESPPEKDP VQEILAHRLW LGFFIDRFEV
VRHNSVEQLL LLGRMLQGTT KFPWRFSRHP AATGSFFTLM LLGLKLCSCQ FQGNLHKFKL
GLQLLEDRIY RASLGWFCHQ PEWFETNNGN FAHSEAQSVH SFVQFLLNQR MDVPQNDSKL
QGQENGNALL NMKDSYHPVW GTMENYAVGR AQRKQLLLML CQHEAERLDV WAMPVPLPGS
KEIITSWKPK INPEKWIEHA RTAFAVDPRI AFSLGARFPT NSPLKMELTH LVQTHILEIR
TIPEALPYFV TPKAVDEDSP LLQQLTHWAA CSITQALEYF TPAYKGHPRV MAYILRVLES
YPPSRVTFFM PQLIQALRYD DEKLVEGYLI RAAQRSDVFS HILIWHLQGE TCTPEQVGKE
GVSAKTTAFL GLLPLVRQHI IDGFSPKARD IFQREFDFFE KVTSISGVLY PLPKEERRAG
IKRELEKIQL DGDDLYLPTA PNKLVKGIQV NSGIPLQSAA KVPIMITFDV ADRNGDPNDL
KPQACIFKVG DDCRQDVLAL QVISLLKDIF EAVGLDLYLF PYGVLPTDPE RGIIEVVPNT
RSRSQMGETT DGGLYEIFQQ DFGAVGSPSF EAARHNFIIS SAGYAVASLL LQPKDRHNGN
LLFDSCGRLV HIDFGFILET SPGGNMRFES AHFKLSHEMT QLLDPSKAMR SETWILFVSL
CVKGYLAARR YMEGIISTVL MMKESGLPCF SRGDPIGNLR KRFHPEMSER EAASFMMRVC
VDAYDKWSTA GYDLIQYLQQ GIEK
//
