ID A0A2J6L194_LACSA Unreviewed; 758 AA.
AC A0A2J6L194;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN ORFNames=LSAT_6X80160 {ECO:0000313|EMBL:PLY81081.1};
OS Lactuca sativa (Garden lettuce).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC Lactucinae; Lactuca.
OX NCBI_TaxID=4236 {ECO:0000313|EMBL:PLY81081.1};
RN [1] {ECO:0000313|EMBL:PLY81081.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28401891; DOI=10.1038/ncomms14953;
RA Reyes-Chin-Wo S., Wang Z., Yang X., Kozik A., Arikit S., Song C., Xia L.,
RA Froenicke L., Lavelle D.O., Truco M.J., Xia R., Zhu S., Xu C., Xu H.,
RA Xu X., Cox K., Korf I., Meyers B.C., Michelmore R.W.;
RT "Genome assembly with in vitro proximity ligation data and whole-genome
RT triplication in lettuce.";
RL Nat. Commun. 8:14953-14953(2017).
CC -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLY81081.1}.
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DR EMBL; NBSK01005415; PLY81081.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2J6L194; -.
DR STRING; 4236.A0A2J6L194; -.
DR EnsemblPlants; rna-gnl|WGS:NBSK|LSAT_6X80160_mrna; cds-PLY81081.1; gene-LSAT_6X80160.
DR Gramene; rna-gnl|WGS:NBSK|LSAT_6X80160_mrna; cds-PLY81081.1; gene-LSAT_6X80160.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0042300; F:beta-amyrin synthase activity; IBA:GO_Central.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IBA:GO_Central.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR002365; Terpene_synthase_CS.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF58; BETA-AMYRIN SYNTHASE-RELATED; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|RuleBase:RU362003};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 99..361
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 417..752
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
SQ SEQUENCE 758 AA; 87123 MW; 800CAA36CDA94F25 CRC64;
MWRLKIAEGG NDPYLYSTNN FVGRQIWEFD SNHGNPEELA EVEQARTHYW NHRHQVKPNS
DLLWRMQFLK EKQFKQTIPQ VKIEDSEEIS YEKATTALRR SVNFFAALQA SDGHWPAENA
GPMYFMQPLV MCLYITGHLD TVFPAEYRKE ILRYLYCHQN EDGGWGFHIE GHSTMFGTTL
SYICMRLLGE GVDGGLNGAC TKARKWILDH GTVTTIPSWG KTWLSILGVC EWAGTNPMPP
EFWLLPSLLP MYPAKMWCYC RLVYMPMSYL YGKRFVGPIT PLILQLRDEL YAQPYNEINW
KSIRHLCAKE DLYYPHPLLQ DLMWDSLYIC TEPLLNRWPF NKLRQKALDT TMKHIHYEDE
NSRYITIGSV EKALCMLACW VEDPNGICFK KHLARIPDYI WVAEDGMKMQ SFGSQEWDAG
LAIQALLAAD LTEEIGPTLM KGHEFIKASQ VKDNPSGDFE SMHRHISKGS WTFSDQDHGW
QVSDCTADGL KCCLIFSTMP PEIVGEVMKP EQLYDAVNII LSLQSKNGGL AAWEPAGSSE
WLEILNPTEF FADIVIEHEY VECTSAAIQA LVLFKKLYPQ HRRKEIESFL TSACGYLEKI
QMQDGSWYGN WGVCFTYGTW FALGGLTAVN KTFENCHAIR KGVKFLLETQ LEDGGWGESY
KSCPEKKYVP LEGGRSNLVH TAWAMMGLIH SRQMERDVTP LHKAAKLLIN SQLENGDFPQ
QEIAGVFMKN CMLHYALYRN IYPMWALADY RKLVLKGI
//
