ID   A0A2J6L275_LACSA        Unreviewed;       712 AA.
AC   A0A2J6L275;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain domain-containing protein {ECO:0000259|SMART:SM01228};
GN   ORFNames=LSAT_3X126721 {ECO:0000313|EMBL:PLY81422.1};
OS   Lactuca sativa (Garden lettuce).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC   Lactucinae; Lactuca.
OX   NCBI_TaxID=4236 {ECO:0000313|EMBL:PLY81422.1};
RN   [1] {ECO:0000313|EMBL:PLY81422.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=28401891; DOI=10.1038/ncomms14953;
RA   Reyes-Chin-Wo S., Wang Z., Yang X., Kozik A., Arikit S., Song C., Xia L.,
RA   Froenicke L., Lavelle D.O., Truco M.J., Xia R., Zhu S., Xu C., Xu H.,
RA   Xu X., Cox K., Korf I., Meyers B.C., Michelmore R.W.;
RT   "Genome assembly with in vitro proximity ligation data and whole-genome
RT   triplication in lettuce.";
RL   Nat. Commun. 8:14953-14953(2017).
CC   -!- FUNCTION: Involved in the 5-carboxymethylaminomethyl modification
CC       (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.
CC       {ECO:0000256|ARBA:ARBA00002739}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- SIMILARITY: Belongs to the MnmG family.
CC       {ECO:0000256|ARBA:ARBA00007653}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PLY81422.1}.
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DR   EMBL; NBSK01005263; PLY81422.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2J6L275; -.
DR   STRING; 4236.A0A2J6L275; -.
DR   EnsemblPlants; rna-gnl|WGS:NBSK|LSAT_3X126721_mrna; cds-PLY81422.1; gene-LSAT_3X126721.
DR   Gramene; rna-gnl|WGS:NBSK|LSAT_3X126721_mrna; cds-PLY81422.1; gene-LSAT_3X126721.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IBA:GO_Central.
DR   GO; GO:0030488; P:tRNA methylation; IBA:GO_Central.
DR   GO; GO:0002098; P:tRNA wobble uridine modification; IBA:GO_Central.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   Gene3D; 1.10.150.570; GidA associated domain, C-terminal subdomain; 1.
DR   Gene3D; 1.10.10.1800; tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG/GidA; 1.
DR   HAMAP; MF_00129; MnmG_GidA; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR049312; GIDA_C_N.
DR   InterPro; IPR004416; MnmG.
DR   InterPro; IPR002218; MnmG-rel.
DR   InterPro; IPR020595; MnmG-rel_CS.
DR   InterPro; IPR026904; MnmG_C.
DR   InterPro; IPR047001; MnmG_C_subdom.
DR   InterPro; IPR044920; MnmG_C_subdom_sf.
DR   InterPro; IPR040131; MnmG_N.
DR   NCBIfam; TIGR00136; gidA; 1.
DR   PANTHER; PTHR11806; GLUCOSE INHIBITED DIVISION PROTEIN A; 1.
DR   PANTHER; PTHR11806:SF0; PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL; 1.
DR   Pfam; PF01134; GIDA; 1.
DR   Pfam; PF13932; GIDA_C; 1.
DR   Pfam; PF21680; GIDA_C_1st; 1.
DR   PRINTS; PR00411; PNDRDTASEI.
DR   SMART; SM01228; GIDA_assoc_3; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   PROSITE; PS01280; GIDA_1; 1.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630}.
FT   DOMAIN          614..685
FT                   /note="tRNA uridine 5-carboxymethylaminomethyl modification
FT                   enzyme C-terminal subdomain"
FT                   /evidence="ECO:0000259|SMART:SM01228"
SQ   SEQUENCE   712 AA;  79612 MW;  1845819DAD17D2FC CRC64;
     MATAAVSLLQ FSRISRRFSL FPFLRPPRSS SISLRRSCKP RLCFSFFRAD SPRHFSVTAS
     SSPDWKNHDT TGDETYDVIV VGGGHAGCEA ALASARLGAK TLLLTINIDR IAWQPCNPAV
     GGPAKSQLVH EVDALGGEIG KMADRCYLQK RVLNISRGPA VRALRAQTDK REYAIEMKKI
     VESTPNLSIR EAMVTDLLMG TNDDVKGVKT FFGMNFYSKS VVLTTGTFMS GKVWVGRTSM
     AAGRAGESAS HGLTEHLQSL GFETDRLKTG TPARVDSRTV DFSVLEPQHG DEEVNWFSFD
     TDYHIEREQM CCYLTRTTEV THQLIRDNLH ETPTYGGWVE AKGPRYCPSI EDKIVRFQDK
     DSHQIFLEPE GRSVPDLYVQ GFSTGLPERL QLPLLRTLPG LEKCSMLRPA YAVEYDYLPA
     HQCARSLMTK KIQGLFFSGQ INGTTGYEEA AAQGIISGIN AARHSDGKPL IVLERESSYI
     GTLIDDLVTK DLREPYRMLT SRSEYRLILR SDNADSRLTP LGREIGLIDD KRWTSYQGKQ
     ARILEEKKRL KTVRVTSEEL AAEVSCLSGQ PVKDHSTLEG LLKKPHIEYK VLEKHGFGNN
     ELSRIEKECI EIDIKYEGLI ARQHSQLQQM VHRQHKPLPA DLDYNSMNTL SHEAREKLSK
     VRPQTIGQAS RVGGVSPADI TALLIIMESN RRKAQELKKH QILASVISGD ST
//