ID A0A2J6LMN4_LACSA Unreviewed; 326 AA.
AC A0A2J6LMN4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LSAT_7X6320 {ECO:0000313|EMBL:PLY88580.1};
OS Lactuca sativa (Garden lettuce).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC Lactucinae; Lactuca.
OX NCBI_TaxID=4236 {ECO:0000313|EMBL:PLY88580.1};
RN [1] {ECO:0000313|EMBL:PLY88580.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28401891; DOI=10.1038/ncomms14953;
RA Reyes-Chin-Wo S., Wang Z., Yang X., Kozik A., Arikit S., Song C., Xia L.,
RA Froenicke L., Lavelle D.O., Truco M.J., Xia R., Zhu S., Xu C., Xu H.,
RA Xu X., Cox K., Korf I., Meyers B.C., Michelmore R.W.;
RT "Genome assembly with in vitro proximity ligation data and whole-genome
RT triplication in lettuce.";
RL Nat. Commun. 8:14953-14953(2017).
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLY88580.1}.
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DR EMBL; NBSK01003032; PLY88580.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2J6LMN4; -.
DR STRING; 4236.A0A2J6LMN4; -.
DR EnsemblPlants; rna-gnl|WGS:NBSK|LSAT_7X6320_mrna; cds-PLY88580.1; gene-LSAT_7X6320.
DR Gramene; rna-gnl|WGS:NBSK|LSAT_7X6320_mrna; cds-PLY88580.1; gene-LSAT_7X6320.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0030267; F:glyoxylate reductase (NADP+) activity; IBA:GO_Central.
DR GO; GO:0016618; F:hydroxypyruvate reductase activity; IBA:GO_Central.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR CDD; cd12156; HPPR; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR PANTHER; PTHR10996:SF255; GLYOXYLATE_HYDROXYPYRUVATE REDUCTASE HPR3-LIKE; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719}.
FT DOMAIN 40..325
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 121..293
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 326 AA; 35337 MW; E66BF135D47488B2 CRC64;
MAQEDHQSPP YLGQVLVIRP PPVFSVHEQY ISSKFQILKA YESPLPTHDF LQTYAQSVKV
VLCSGGSPIT ADVLHDLPAL QLVVSSTTGV NHIDMAECRR REIRVTNTGD LFSDDVADGA
VGLLIDVMRR ISAGDRFVRG GRWPAISEYP LGSKLGGKRV GIVGLGNIGS SVATRLEAMG
CIVSYTSRQK KNSTHYTFYP NVLQLASNSD ALIICCALTN DTRHMINNTV LRALGKTGVI
VNVARGAIID EVELVECLVE GEVGGAGLDV FEKEPKVPNE LFELDNVVLS SHSTACTREC
FYDAAQTVVA NLEAFFMSKP LLTPVS
//
