ID A0A2J6LNG0_LACSA Unreviewed; 442 AA.
AC A0A2J6LNG0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Cysteine protease {ECO:0008006|Google:ProtNLM};
GN ORFNames=LSAT_5X25740 {ECO:0000313|EMBL:PLY88863.1};
OS Lactuca sativa (Garden lettuce).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC Lactucinae; Lactuca.
OX NCBI_TaxID=4236 {ECO:0000313|EMBL:PLY88863.1};
RN [1] {ECO:0000313|EMBL:PLY88863.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28401891; DOI=10.1038/ncomms14953;
RA Reyes-Chin-Wo S., Wang Z., Yang X., Kozik A., Arikit S., Song C., Xia L.,
RA Froenicke L., Lavelle D.O., Truco M.J., Xia R., Zhu S., Xu C., Xu H.,
RA Xu X., Cox K., Korf I., Meyers B.C., Michelmore R.W.;
RT "Genome assembly with in vitro proximity ligation data and whole-genome
RT triplication in lettuce.";
RL Nat. Commun. 8:14953-14953(2017).
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLY88863.1}.
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DR EMBL; NBSK01002922; PLY88863.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2J6LNG0; -.
DR STRING; 4236.A0A2J6LNG0; -.
DR EnsemblPlants; rna-gnl|WGS:NBSK|LSAT_5X25740_mrna; cds-PLY88863.1; gene-LSAT_5X25740.
DR Gramene; rna-gnl|WGS:NBSK|LSAT_5X25740_mrna; cds-PLY88863.1; gene-LSAT_5X25740.
DR OrthoDB; 5472443at2759; -.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IBA:GO_Central.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 2.10.25.160; Granulin; 1.
DR InterPro; IPR000118; Granulin.
DR InterPro; IPR037277; Granulin_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF414; OS05G0508300 PROTEIN; 1.
DR Pfam; PF00396; Granulin; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00277; GRAN; 1.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF57277; Granulin repeat; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022807};
KW Protease {ECO:0000256|ARBA:ARBA00022807}; Signal {ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..442
FT /note="Cysteine protease"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018532869"
FT DOMAIN 30..87
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 120..335
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
FT DOMAIN 352..409
FT /note="Granulins"
FT /evidence="ECO:0000259|SMART:SM00277"
FT REGION 420..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 442 AA; 49219 MW; 8592BC4CEF0D75A5 CRC64;
MGWLWWISAL FFFFLFPLTS LSTSYTSDLF RQWCQQHGKS YSTEEENLYR FNVFEDNYAY
IIRHNSNSNS SYTLSLNSFA DLTHHEFKLA RLRGLSASAA SDDLIRLNRG SSLIESSSYL
PKSLDWRDKG AVTNVKDQGS CGACWSFSAT GAMEGINQIV TGSLISLSEQ ELVDCDKSFN
SGCEGGLMDY AYEFVIKNKG IDTEDDYPYQ AKQTSCNKNK RKRNIVTIDG YNDIPENNED
QLLKAVANQP VSVGICGSER AFQLYSKGIF TGPCSTALDH AVLIVGYDSK DGVDYWIIKN
SWGNSWGING YMYMARNTGD SHGLCGINML ASYPIKTSPN PPPSPTPKPV KCNLFSWCSE
GETCCCASNF LGICLKWTCC ELNAAVCCKD HRHCCPSDYP ICDSERNLCL KQTNNGTLAI
QPKKNSDSGN SGGRSTLHKQ YF
//
