ID A0A2J6LV25_LACSA Unreviewed; 298 AA.
AC A0A2J6LV25;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 13-SEP-2023, entry version 19.
DE RecName: Full=Protein-L-isoaspartate O-methyltransferase {ECO:0000256|RuleBase:RU003802};
DE EC=2.1.1.77 {ECO:0000256|RuleBase:RU003802};
GN ORFNames=LSAT_4X78581 {ECO:0000313|EMBL:PLY91190.1};
OS Lactuca sativa (Garden lettuce).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC Lactucinae; Lactuca.
OX NCBI_TaxID=4236 {ECO:0000313|EMBL:PLY91190.1};
RN [1] {ECO:0000313|EMBL:PLY91190.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28401891; DOI=10.1038/ncomms14953;
RA Reyes-Chin-Wo S., Wang Z., Yang X., Kozik A., Arikit S., Song C., Xia L.,
RA Froenicke L., Lavelle D.O., Truco M.J., Xia R., Zhu S., Xu C., Xu H.,
RA Xu X., Cox K., Korf I., Meyers B.C., Michelmore R.W.;
RT "Genome assembly with in vitro proximity ligation data and whole-genome
RT triplication in lettuce.";
RL Nat. Commun. 8:14953-14953(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-L-isoaspartate + S-adenosyl-L-methionine =
CC [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:12705, Rhea:RHEA-COMP:12143, Rhea:RHEA-
CC COMP:12144, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:90596,
CC ChEBI:CHEBI:90598; EC=2.1.1.77;
CC Evidence={ECO:0000256|RuleBase:RU003802};
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. L-
CC isoaspartyl/D-aspartyl protein methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005369, ECO:0000256|RuleBase:RU003802}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLY91190.1}.
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DR EMBL; NBSK01002178; PLY91190.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2J6LV25; -.
DR STRING; 4236.A0A2J6LV25; -.
DR EnsemblPlants; rna-gnl|WGS:NBSK|LSAT_4X78581_mrna; cds-PLY91190.1; gene-LSAT_4X78581.
DR Gramene; rna-gnl|WGS:NBSK|LSAT_4X78581_mrna; cds-PLY91190.1; gene-LSAT_4X78581.
DR OrthoDB; 303909at2759; -.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004719; F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity; IBA:GO_Central.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000682; PCMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR00080; pimt; 1.
DR PANTHER; PTHR11579; PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR11579:SF28; PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE 1; 1.
DR Pfam; PF01135; PCMT; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS01279; PCMT; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|RuleBase:RU003802};
KW S-adenosyl-L-methionine {ECO:0000256|RuleBase:RU003802};
KW Transferase {ECO:0000256|RuleBase:RU003802}.
SQ SEQUENCE 298 AA; 32462 MW; 1DC88355E43510A1 CRC64;
MKMSSSVVAY SFRHIPPLKQ RSIRYFSHQS PLRRRPLCSP CSVLVATSTS SCSLPNSASF
TGNSLFRRME RYWAASSINK NKGMVEHLQR YGVIQSKKVA EVMETVDRAL FVPDGSSAYE
DSPMQIGFNA TISAPHMHAT CLQLLEKNLQ PGMHALDVGS GTGYLTACFA LMVGPQGHAI
GVDHIPELVT MSIKNIEKSA AAPLLKDGSL ALHVGDGREG WVEFAPYDAI HVGAAAPEIP
QPLIDQLKPG GRLVIPVGNV FQELKVVDKK EDGSVSVRSE TSVRYVPLTS REAQLRGY
//
