ID   A0A2J6M3F8_LACSA        Unreviewed;       686 AA.
AC   A0A2J6M3F8;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE            EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN   ORFNames=LSAT_5X17060 {ECO:0000313|EMBL:PLY94148.1};
OS   Lactuca sativa (Garden lettuce).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC   Lactucinae; Lactuca.
OX   NCBI_TaxID=4236 {ECO:0000313|EMBL:PLY94148.1};
RN   [1] {ECO:0000313|EMBL:PLY94148.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=28401891; DOI=10.1038/ncomms14953;
RA   Reyes-Chin-Wo S., Wang Z., Yang X., Kozik A., Arikit S., Song C., Xia L.,
RA   Froenicke L., Lavelle D.O., Truco M.J., Xia R., Zhu S., Xu C., Xu H.,
RA   Xu X., Cox K., Korf I., Meyers B.C., Michelmore R.W.;
RT   "Genome assembly with in vitro proximity ligation data and whole-genome
RT   triplication in lettuce.";
RL   Nat. Commun. 8:14953-14953(2017).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PLY94148.1}.
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DR   EMBL; NBSK01001489; PLY94148.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2J6M3F8; -.
DR   STRING; 4236.A0A2J6M3F8; -.
DR   EnsemblPlants; rna-gnl|WGS:NBSK|LSAT_5X17060_mrna; cds-PLY94148.1; gene-LSAT_5X17060.
DR   Gramene; rna-gnl|WGS:NBSK|LSAT_5X17060_mrna; cds-PLY94148.1; gene-LSAT_5X17060.
DR   OrthoDB; 5489991at2759; -.
DR   UniPathway; UPA00143; -.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd16664; RING-Ubox_PUB; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR045210; RING-Ubox_PUB.
DR   InterPro; IPR003613; Ubox_domain.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR23315:SF116; RING-TYPE E3 UBIQUITIN TRANSFERASE; 1.
DR   PANTHER; PTHR23315; U BOX DOMAIN-CONTAINING; 1.
DR   Pfam; PF00514; Arm; 1.
DR   Pfam; PF04564; U-box; 1.
DR   SMART; SM00185; ARM; 3.
DR   SMART; SM00504; Ubox; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 1.
DR   PROSITE; PS51698; U_BOX; 1.
PE   4: Predicted;
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          277..351
FT                   /note="U-box"
FT                   /evidence="ECO:0000259|PROSITE:PS51698"
FT   REPEAT          421..463
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
SQ   SEQUENCE   686 AA;  76181 MW;  488FDD842DEE0E2A CRC64;
     MLKRFDDNSR RILRFPAVLP CQDVNPVTLL RSLITLSNSI TNYQSELFAT QRKNVRESIR
     QIGILSMFFC EIMEQDVSGL PDPAVLCFSE LHHSFQKIRF LFEDCTRSGA RVFILMKSHF
     VATQFLTLIR AVATALDILP LNSIKVSTEM KELVEMVAKQ ARRAKMEVDP DDDYAMRRVM
     LILNQFENRF EPDPIIIKRV LYYLGINSWS DCHSEIRFLD EEISLVSLEN NERDLHLLST
     LAGFMRYCRG VLFENFVLEN TDDQSAGRSN LEILSCLNPE DFRCPISLEM MIDPVTVSTG
     QTYDRVSIEK WLKSGNLICP KTGKKLATTE LVPNLNLRKV IQQYCIDHGV SITKFQKQAR
     DISSTILPGS PSSAEAIKFL SEYLVRKLRN GTEKQKSKAA YEIRLLAKSN IYNRFCLIGA
     GAIPLLLTRL SSSDSTIQEN AIAALLKLSK HSNGKKVIIN NGGLNSILEV LKNGSKQESK
     QIAAATIFYL SSVQANQKLI GEIPDAIPAL IEQIKTGTSC GKKNSLAALF GILLYPRNHQ
     TALSSGIVPL LSSLISCSDK PEIITDSLAV LATLAESFDG SDTIMKASSL PLIIKTLQTS
     PSRAAKEYCV SILLALCNNM GVEVIAVLAN NANLIGFLYT MSTNGGSQAG KKARSLIQVM
     HRFHETSSSG MVANWDSSRI ATIHSC
//