ID A0A2J6M5M7_LACSA Unreviewed; 381 AA.
AC A0A2J6M5M7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Fatty acid desaturase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LSAT_2X101240 {ECO:0000313|EMBL:PLY94794.1};
OS Lactuca sativa (Garden lettuce).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC Lactucinae; Lactuca.
OX NCBI_TaxID=4236 {ECO:0000313|EMBL:PLY94794.1};
RN [1] {ECO:0000313|EMBL:PLY94794.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28401891; DOI=10.1038/ncomms14953;
RA Reyes-Chin-Wo S., Wang Z., Yang X., Kozik A., Arikit S., Song C., Xia L.,
RA Froenicke L., Lavelle D.O., Truco M.J., Xia R., Zhu S., Xu C., Xu H.,
RA Xu X., Cox K., Korf I., Meyers B.C., Michelmore R.W.;
RT "Genome assembly with in vitro proximity ligation data and whole-genome
RT triplication in lettuce.";
RL Nat. Commun. 8:14953-14953(2017).
CC -!- PATHWAY: Lipid metabolism; polyunsaturated fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005105}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the fatty acid desaturase type 1 family.
CC {ECO:0000256|ARBA:ARBA00009295}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLY94794.1}.
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DR EMBL; NBSK01001275; PLY94794.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2J6M5M7; -.
DR STRING; 4236.A0A2J6M5M7; -.
DR EnsemblPlants; rna-gnl|WGS:NBSK|LSAT_2X101240_mrna; cds-PLY94794.1; gene-LSAT_2X101240.
DR Gramene; rna-gnl|WGS:NBSK|LSAT_2X101240_mrna; cds-PLY94794.1; gene-LSAT_2X101240.
DR OrthoDB; 4215at2759; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR GO; GO:0016717; F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd03507; Delta12-FADS-like; 1.
DR InterPro; IPR005804; FA_desaturase_dom.
DR InterPro; IPR021863; FAS_N.
DR InterPro; IPR012171; Fatty_acid_desaturase.
DR PANTHER; PTHR32100:SF13; DELTA(12)-FATTY-ACID DESATURASE; 1.
DR PANTHER; PTHR32100; OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC; 1.
DR Pfam; PF11960; DUF3474; 1.
DR Pfam; PF00487; FA_desaturase; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 55..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 86..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..66
FT /note="Fatty acid desaturase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11960"
FT DOMAIN 85..345
FT /note="Fatty acid desaturase"
FT /evidence="ECO:0000259|Pfam:PF00487"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 381 AA; 43901 MW; 53948675067791D9 CRC64;
MGAGGCMSVS ETKPEEKKNP LKRVPCAKPP FTISDIKKAI PPHCFNRSLT RSFSYVIYDL
VISFLLYHIA TTYFHRLPTP LSSLAWLAYW VVQGCVLTGV WVLAHECGHH AFSDYQWVDD
TVGFLLHSAL LVPYFSWKYS HRRHHSNTGS LERDEVFVPK PRSKIPWYSK YLNNPLGRIM
SLFATLTLGW PLYLAFNVSG RPYDRFACHY SPNSPIYNDR ERLQIWLSDV GIITMSLFLY
RVALVKGVSW VIFVYGIPLL IVNGFLVLIT YLQHTHPSLP HYDGSEWDWL RGALATVDRD
YGVLNKVFHN ITDTHVVHHL FSTMPHYNAM EATKAVMPVL GEYYQLDETP FYVAMWREAK
ECLFVEAEGE GGGVFWYKNK M
//
