ID A0A2J6MDP5_LACSA Unreviewed; 3370 AA.
AC A0A2J6MDP5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Vacuolar protein sorting-associated protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LSAT_8X5081 {ECO:0000313|EMBL:PLY97712.1};
OS Lactuca sativa (Garden lettuce).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC Lactucinae; Lactuca.
OX NCBI_TaxID=4236 {ECO:0000313|EMBL:PLY97712.1};
RN [1] {ECO:0000313|EMBL:PLY97712.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28401891; DOI=10.1038/ncomms14953;
RA Reyes-Chin-Wo S., Wang Z., Yang X., Kozik A., Arikit S., Song C., Xia L.,
RA Froenicke L., Lavelle D.O., Truco M.J., Xia R., Zhu S., Xu C., Xu H.,
RA Xu X., Cox K., Korf I., Meyers B.C., Michelmore R.W.;
RT "Genome assembly with in vitro proximity ligation data and whole-genome
RT triplication in lettuce.";
RL Nat. Commun. 8:14953-14953(2017).
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLY97712.1}.
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DR EMBL; NBSK01000377; PLY97712.1; -; Genomic_DNA.
DR STRING; 4236.A0A2J6MDP5; -.
DR EnsemblPlants; rna-gnl|WGS:NBSK|LSAT_8X5081_mrna; cds-PLY97712.1; gene-LSAT_8X5081.
DR Gramene; rna-gnl|WGS:NBSK|LSAT_8X5081_mrna; cds-PLY97712.1; gene-LSAT_8X5081.
DR OrthoDB; 449127at2759; -.
DR GO; GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0045053; P:protein retention in Golgi apparatus; IBA:GO_Central.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF93; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 1.
DR Pfam; PF06650; VPS13_VAB; 2.
PE 3: Inferred from homology;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 2..115
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12624"
FT DOMAIN 137..368
FT /note="Vacuolar protein sorting-associated protein 13
FT extended chorein"
FT /evidence="ECO:0000259|Pfam:PF16908"
FT DOMAIN 596..819
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1990..2296
FT /note="Vacuolar protein sorting-associated protein 13 VPS13
FT adaptor binding"
FT /evidence="ECO:0000259|Pfam:PF06650"
FT DOMAIN 2368..2632
FT /note="Vacuolar protein sorting-associated protein 13 VPS13
FT adaptor binding"
FT /evidence="ECO:0000259|Pfam:PF06650"
FT DOMAIN 2925..3093
FT /note="Vacuolar protein sorting-associated protein 13 DH-
FT like"
FT /evidence="ECO:0000259|Pfam:PF16909"
SQ SEQUENCE 3370 AA; 377958 MW; 2C616FBC1297215F CRC64;
MFEGLVRQLI LGYLGQYIKD IHREQLKITL WNEEVFLENV ELILEAFDYL ELPFALKQGR
VGRLSIRIPW KKLGWDPIII ILEDILVCAS QREDEEWSVD DVERREFAGK KAKLATAELA
KLSQRVCDND NQTGKSFISY ITAKIIDGIQ VTIRNVHVVY RDISNDKAQT VFGLKLASLT
AMKQNLVGVL NGKVRAGQVN KLVEIQGLEI YCKTFHGSAE DLYTNNGEDS MSMVAASFEN
DEHVHLLSPV DVSASLSVNR SGRLENNAAQ YSVDIELSGL VLSLDEDQLQ QILYLYDYLC
TCRLREKYGR YRPWGIPISD RPLGWQIQWW HYAQNSVLSD VRKRMKKTSW KYLGERLGRK
RRYVKLYKLK LECLRKEQPL DDEIVLELDQ MEKVSDIEDI LSYRSAAEHE LQEFLVDSAS
GFGNSEANAT IDKSMDDDQT SGKPQGWLKW LSRGMLGAGG TDDSSQFSGV VSDEVIKDIY
EATKFHPAPS PVLDAAGSDR LLLSSIKCSI HRISATLRNK DLDCSIGELV FEENLVECMI
WEESAVVTAS INGVEMINSL NKQVVLRVKR AISEENFIQV EKPSLNFQAY IPQANREGDL
TLKVLLEPIE MTCDPTYLVN FVELYTVLAS FQSHEGRVLN SLNGIKDMKS RLISKAEYML
SGRKRMMWDI SLINIKIIIP WENGKSEIHK LVLGLTAVTF SSKHDVSCFA PDINVPSQFM
RNLIDDNSSS ELLEGTQIQD LYDLMEIKLV DFQINLFVSF YPTHYFPILE KLNASSALAL
CIVQDESLLK AMEVYVVVAP FLGHLSPSII GSVLKLVETI DMLHHASHLG TTSATSDKPN
NFSSVSVVAN LESGSFIVDL ENGLEESCTL TVSLQDLDMR LITVKQAQSF WICTRAFKVM
SRLLKNGDDM DLINVSPNGL SQLNNGCLML HYDGDLSIWL TDLDLHCYPH IIGLLIEFFD
KLPEYSPSHS HDDKNQEFVG RNSNSVLSGS YFGCSNFYDT CSSDWESISV DHYPFVTIHN
DRSLVSLESS LININPDWKK VLKIREGKIS CSKKEFQKLS VSDPDLVVIN LDLRSIRLHL
HDSSSIVAYF TLPTAKSCIS IHESCLDVLC STEGLSLSSQ WFPQTLQDSL WGPALLNLSP
VINIRVRKGN HGMELDFSIQ NVSCILPTEF LAVLIGYFSM PDWNLNAKES SGIDCSKDTD
SFPFTYNYKF EILDSVLFTP VANADYQFLK LNIPQMYFTF IENSDSDILL KEIPLECSVP
PGFIGDQNYC LNVFGRDLSL HHTLWKDNAS EVTSVSIIAP FSGDIWITIP YGSDSPSATC
MMSKVNKCQF IVEGSEILGC FDALLDVIDQ FTSVENLSMC FTSDVSEFLN SKDSFKENHV
LQVPTESSSV SFTEIRCSVE SMSVELYSDK IQSNANEHIA KTDMKFTCSV SLKNEKPLSL
DVSFTCLTLS SMFTSVVLLE CTSYTKKVPV LYMKLLMSDE GENHLRFSLP CVDIWLFLSE
WSQVVDLVNS CYENLPKTAI QNEEPEKSIS EPVSRVDTAE NSPQSISVSS FLSPEDRFSL
TVKSDHIGIK IRVPVQVSGE AFKYFGAPQV REQNSFVGRD DGSFLYIYLQ SRCTEANING
EKVNLKSNLG KAMGTVELFQ NKSVHSWPLF QLLEIDIEAE AGNDDMDLMH LKTEVHCDNL
DIWLSHHTFY LWPTTPEDSG SSQLSVGSVN FRFHLRKVSI LLTDEKWSSN GPLLEILMGS
LLFHGIITAN VMEGWVDSEL QVNYNNIHKV LWEPFLEPWK FQVSLRREQG KSALENSPVM
TDVHLESTMN LNINVTESFI EVAFRTFDMI TDAWDLMSLN VFPENSRLTA AAHTNENTNT
LASRYAPYTL ENLTSLPLVF YISKADGFNI LKDGKYVQPG SSYPVYIDDN TDEQTFGFKP
SHSTDNLGDK KFADAQHHYI VIQLEGTSTL SAPVSIDLVG VSFFEVDFSN SVVNSRDISK
GVNSGYVVPL VIDVSVQRYT KLVRLYSTVI LTNATTMPFE VRFDIPFGVS PKILDPVYPG
HEFPLPLHLA ESGRIRWRPL GNTYLWSEAY SISNILSNES KIGHLRSFVC YPSLPSSHPF
RCCVSVHDVC LPSAGTGRVN KGSNLYIHDA IADKIENQDQ SNKRCIHLIT LSNPLIVKNY
LPVEVSVMIE SGGVSCSMLL SEVETSFYHI DSSHDLSLTF DIHGFRPSVL KFPRAEKFSE
IAKFSGTKFS SSESINFTAD ISKGPLYVTM EKVMDAFSGA REICIFVPFL LYNCCGFPLT
IANSTNDLTM RDTLPSCYDL DEEDPFLGKK DGLSLLSSHQ ILNNDGMTMR RFPLNNNLVS
TRKESFSSSG SNKKNIISTP YDEEKSLVSN NQQIDLDETS RKKVNFRMYS PDPNIASSEI
MVRVSRSHSE SDVASTSNYT WSSEFFLVPP TGSTTVLVPR SSANSSYVIS VASSAISGPY
SGRTRIINFQ PRYVISNACS KDLCYRQKGS DFIYHLKVGQ HSHIHWTDVT RELLVSARFD
EPGWQWSGCF LPEHLGDTQL KMRNYVTGAV SMVRVEVQNA DDAIRDDKIV GNPHGDSGTN
LILLSDDDTG FMPYRIDNFS KERLRVYQQK CEAFETVIHS YTSCPYAWDE PSYPHRLTVE
VFAERVVGSY TLDDAKEYKP VVLPSTSEKP ERRLLISVHA EGALKVLSII DSSYHIFDDI
KISRSPRLTD KKEDDQKQES CERLSVSIPF IGISVMSSQP QELLFACARN TSIDLVQSLD
QQKFSLKIFA LQIDNQLPTT PYPVILSFDH EYKQMATSQI KSKDASCEPV FSLAAAKWRN
KDRALLSFEH INLKMTDFHL ELEQDVILSL FDLFKAVSSR FHSRGMPHMD TVLLPLSSNL
SVNNKKNKFS DTEKEDSESF PLLPSIVPIG APWQKIYLLA RKQKKIYVEL LEVAPITLTL
SFSSSPWMLR NGILTSGEFL IHRGLMALAD VEGARIHLRR LTISHQLASL ESIREILIIH
YTRQLLHEMY KVFGSAGVIG NPMGFARSVG VGIKDFLSVP ARSFMKSPAG LITGMAQGTT
SLVSNTVYAI SDAATQVSRA AHKGIVAFTM DDDPSASEME RQQKKGMSSH GKGVINEVLE
GLTGLLQSPI RGAEKHGLPG VLSGIALGVT GLVARPAASI LQVTEKTARS IRNRSKLYHM
GSQRLRVRLP RPLSPNYPLK PYSWEQSIGI SVIISSDSNT LKDETLVLSK SLKHGGKFII
ITQRLILIVT SASLVNLGKP EFKGVPADPD WVIEAEIRLD SVIHVDVDDE VVHIVGSSSD
VVVRQNINQG GGGKQRWYNP PTPLPLFQTN LECSGKEEAG ELLKVLLVTI EKGKERGWGC
VYRLHQSSVR
//
