ID A0A2J6MIS3_LACSA Unreviewed; 1112 AA.
AC A0A2J6MIS3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=TOG domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LSAT_1X67421 {ECO:0000313|EMBL:PLY99357.1};
OS Lactuca sativa (Garden lettuce).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC Lactucinae; Lactuca.
OX NCBI_TaxID=4236 {ECO:0000313|EMBL:PLY99357.1};
RN [1] {ECO:0000313|EMBL:PLY99357.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28401891; DOI=10.1038/ncomms14953;
RA Reyes-Chin-Wo S., Wang Z., Yang X., Kozik A., Arikit S., Song C., Xia L.,
RA Froenicke L., Lavelle D.O., Truco M.J., Xia R., Zhu S., Xu C., Xu H.,
RA Xu X., Cox K., Korf I., Meyers B.C., Michelmore R.W.;
RT "Genome assembly with in vitro proximity ligation data and whole-genome
RT triplication in lettuce.";
RL Nat. Commun. 8:14953-14953(2017).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLY99357.1}.
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DR EMBL; NBSK01000043; PLY99357.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2J6MIS3; -.
DR STRING; 4236.A0A2J6MIS3; -.
DR EnsemblPlants; rna-gnl|WGS:NBSK|LSAT_1X67421_mrna; cds-PLY99357.1; gene-LSAT_1X67421.
DR Gramene; rna-gnl|WGS:NBSK|LSAT_1X67421_mrna; cds-PLY99357.1; gene-LSAT_1X67421.
DR OrthoDB; 24319at2759; -.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040122; Importin_beta.
DR InterPro; IPR041653; Importin_rep_4.
DR InterPro; IPR041389; Importin_rep_6.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR PANTHER; PTHR10527:SF5; IMPORTIN-5 ISOFORM X1; 1.
DR Pfam; PF02985; HEAT; 1.
DR Pfam; PF13513; HEAT_EZ; 2.
DR Pfam; PF18808; Importin_rep_4; 1.
DR Pfam; PF18829; Importin_rep_6; 1.
DR SMART; SM00913; IBN_N; 1.
DR SMART; SM01349; TOG; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 37..111
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|SMART:SM00913"
FT DOMAIN 365..602
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 416..454
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ SEQUENCE 1112 AA; 123097 MW; 8FD601F0F7B37C7C CRC64;
MDPQVQQTQL AAILGADPAP FETLISHLMS SSNEQRSQAE LLFNLCKQTD PNTLVLKLAQ
LLQLSPHMEA RAMSAILLRK QLTQDDSLMW NMLSPATQAS LKSVLVTCVQ NEEAKTIMKK
LCDTISELGA SILPENGWPE LLPFMFQCVS SDSPKLQESA FLIFAQLSQY VGDTLVPHIK
HLHGVFLQCL TTSASSDVRI AALSAVINFI QCLSSSGDRD RFQDLLPAMM RTLTEALNGG
QEATAQEALE LLIELAGTEP RFLRRQLVEV VGSMLQIAEA ETLEEGTRHL AIEFVITLAE
ARERAPGMMR KLPQFISRLF AILMQMLLDI EDEPAWHSAE NEDEDAGESS NYSVGQECLD
RLAIALGGNT IVPVASEQLP AYLAAPEWQK HHAALVALAQ IAEGCSKVMI KNLEQVVTMV
LNSFQDPHPR VRWSAINAIG QLSTDLGPDL QVQYHQRVLP ALASAMDDFQ NPRVQAHAAS
AVLNFSENCT PDILTPYLDG IVSKLLVLLQ NGKQMVQEGA LTALASVADS SQEHFQKYYD
AVMPYLKAIL VNANDKANRM LRAKAMECIS LVGMAVGKEK FRDDAKQVME VLMSLQGTQM
ENDDPTTSYM LQAWARLCKC LGQDFLPYMS VVMPPLLQSA QLKPDVIITS ADSDDEIESD
DESIETITLG DKRIGIKTSV LEEKATACNM LCCYADELKE GFYPWIDQVA PTLVPLLKFY
FHEEVRKAAV SAMPELLRSA KLAIEKGLAQ GRDGSYIKQL SDYIIPALVE ALHKEPDTEI
CANMLDALNE CLQISGQVLD ENQVRSIVDE IKQVITASSS RKKERAERTN AEDFDAEEGE
LLKEENEQEE EVFDQVGEIL GTLVKTFKAS FLPFFDELSS YIMPMWGKDK TTEERRIAIC
IFDDVAEQCR EAALKYYDTY VPFLLDACND ENPDIRQAAV YGLGVCAEHG GSVIKPLVGE
VLSRLNFVIR HPNALQPDNI MAYDNAVSAL GKVCQFHRDT IDSAQVIPAW LSCLPIKGDL
IEAKVVHDLL CSMVERSDVE ILGPNNQYLP KIVSIFAEIL CGGKELASEQ TVSRIINLLR
QLQQTLPPAT LASTWSTLQP QQQLALQSIL SS
//
