ID   A0A2J6MJQ5_LACSA        Unreviewed;       615 AA.
AC   A0A2J6MJQ5;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:PLY99830.1};
GN   ORFNames=LSAT_5X51160 {ECO:0000313|EMBL:PLY99830.1};
OS   Lactuca sativa (Garden lettuce).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC   Lactucinae; Lactuca.
OX   NCBI_TaxID=4236 {ECO:0000313|EMBL:PLY99830.1};
RN   [1] {ECO:0000313|EMBL:PLY99830.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=28401891; DOI=10.1038/ncomms14953;
RA   Reyes-Chin-Wo S., Wang Z., Yang X., Kozik A., Arikit S., Song C., Xia L.,
RA   Froenicke L., Lavelle D.O., Truco M.J., Xia R., Zhu S., Xu C., Xu H.,
RA   Xu X., Cox K., Korf I., Meyers B.C., Michelmore R.W.;
RT   "Genome assembly with in vitro proximity ligation data and whole-genome
RT   triplication in lettuce.";
RL   Nat. Commun. 8:14953-14953(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PLY99830.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; NBSK01000009; PLY99830.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2J6MJQ5; -.
DR   STRING; 4236.A0A2J6MJQ5; -.
DR   EnsemblPlants; rna-gnl|WGS:NBSK|LSAT_5X51160_mrna; cds-PLY99830.1; gene-LSAT_5X51160.
DR   Gramene; rna-gnl|WGS:NBSK|LSAT_5X51160_mrna; cds-PLY99830.1; gene-LSAT_5X51160.
DR   UniPathway; UPA00053; UER00087.
DR   GO; GO:0003855; F:3-dehydroquinate dehydratase activity; IEA:InterPro.
DR   GO; GO:0004764; F:shikimate 3-dehydrogenase (NADP+) activity; IBA:GO_Central.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IBA:GO_Central.
DR   GO; GO:0009793; P:embryo development ending in seed dormancy; IEA:EnsemblPlants.
DR   GO; GO:0019632; P:shikimate metabolic process; IBA:GO_Central.
DR   CDD; cd00502; DHQase_I; 1.
DR   CDD; cd01065; NAD_bind_Shikimate_DH; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   Gene3D; 3.40.50.10860; Leucine Dehydrogenase, chain A, domain 1; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   HAMAP; MF_00214; AroD; 1.
DR   HAMAP; MF_00222; Shikimate_DH_AroE; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR   InterPro; IPR001381; DHquinase_I.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR013708; Shikimate_DH-bd_N.
DR   InterPro; IPR022893; Shikimate_DH_fam.
DR   InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR   NCBIfam; TIGR01093; aroD; 1.
DR   PANTHER; PTHR21089:SF1; BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE_SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC; 1.
DR   PANTHER; PTHR21089; SHIKIMATE DEHYDROGENASE; 1.
DR   Pfam; PF01487; DHquinase_I; 1.
DR   Pfam; PF01488; Shikimate_DH; 1.
DR   Pfam; PF08501; Shikimate_dh_N; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
DR   SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
FT   DOMAIN          256..336
FT                   /note="Shikimate dehydrogenase substrate binding N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08501"
FT   DOMAIN          380..450
FT                   /note="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA
FT                   reductase"
FT                   /evidence="ECO:0000259|Pfam:PF01488"
SQ   SEQUENCE   615 AA;  67399 MW;  5297E35824F41B6E CRC64;
     MELVTPAIEK MGGREGIRRN STLICAPIMA DTVDQMLIQM NSAKSYGADL VEIRLDSLKG
     FNAREAIQTL VKLSPLPTLF TYRPTWEGGQ YNGDEESRLD ALRLAMELGA DHIDVELQAV
     DDFNNLIQGD KPTKCKLIVS SHNYENTPSV EELGNLVAKI QSTGADIVKF ATTAVDITDV
     ARVFQITAHS QVPIIAMVMG EKGLMSRVLC PKFGGYLTFG TLEHGKVSAP GQPTIRDLLD
     LFNFRQLGPD TKVFGIIGKP VGHSKSPLLY NQAFRSVGFN GVYVHMLVDN VKNFLDTYSS
     TDFAGFSCTI PHKESIVQCC DEVDPVAKSI GAVNCVVRRQ SDGKLYGCNT DYVGAISAIE
     DGLRGPGVQN GVRGSSSPLA GRLFVVIGAG GAGKALAYGA KEKGARIVIA NRTYDRAREL
     AEIIGGEALS LADLSSYAPE EGMILANTTS IGMQPNIHET PISKEALKSY ALVFDAVYTP
     KITRLLREAG ECGAKIVTGV EMFIGQAYEQ YERFTGLPVR LWQSIDCCGP FTLKLEALKQ
     YVVYKVVHTG NRKKIIPILI SASFVIVSSS FLTPFHKALR HLCKEPFKKI IRQHPLHFNT
     LYPYHHFNNS YPYIN
//