ID   A0A2J6Q2C3_9HELO        Unreviewed;       350 AA.
AC   A0A2J6Q2C3;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 13.
DE   SubName: Full=NAD(P)-binding protein {ECO:0000313|EMBL:PMD20366.1};
GN   ORFNames=NA56DRAFT_646491 {ECO:0000313|EMBL:PMD20366.1};
OS   Hyaloscypha hepaticicola.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Hyaloscyphaceae; Hyaloscypha.
OX   NCBI_TaxID=2082293 {ECO:0000313|EMBL:PMD20366.1, ECO:0000313|Proteomes:UP000235672};
RN   [1] {ECO:0000313|EMBL:PMD20366.1, ECO:0000313|Proteomes:UP000235672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 7357 {ECO:0000313|EMBL:PMD20366.1,
RC   ECO:0000313|Proteomes:UP000235672};
RG   DOE Joint Genome Institute;
RA   Martino E., Morin E., Grelet G., Kuo A., Kohler A., Daghino S., Barry K.,
RA   Choi C., Cichocki N., Clum A., Copeland A., Hainaut M., Haridas S.,
RA   Labutti K., Lindquist E., Lipzen A., Khouja H.-R., Murat C., Ohm R.,
RA   Olson A., Spatafora J., Veneault-Fourrey C., Henrissat B., Grigoriev I.,
RA   Martin F., Perotto S.;
RT   "A degradative enzymes factory behind the ericoid mycorrhizal symbiosis.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004406}.
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|ARBA:ARBA00009219}.
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DR   EMBL; KZ613485; PMD20366.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2J6Q2C3; -.
DR   STRING; 1745343.A0A2J6Q2C3; -.
DR   OrthoDB; 1133at2759; -.
DR   Proteomes; UP000235672; Unassembled WGS sequence.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR   PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000235672}.
FT   DOMAIN          9..271
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
SQ   SEQUENCE   350 AA;  38027 MW;  5016F22DD75DCE53 CRC64;
     MSLDNRIVLI TGGCGQVGFA IAEYLQTRHP TTKIHILDLS LPSTQSQKIT CHTGSITDVS
     AISSLFSLIK PEVVFHTAGL IPSIAIRLGL NTEKDFKEVN LEGTRIVLEE AKKVGVKAFV
     YTSSADVVKG NSWQDLKGVD EDMSIPEVFD SAYGKSKALA EALVLSTSTP TFPTTALRTH
     AVFSAKDTNL IPLMLAAPRN LHLGPGTNLY DFTYAPNLAQ AHVLAAINLL TIPPPTSSAA
     GKPFFVTNAE PLPFRVFLKM LWTEFDGKEP EKGISVPTKV AVVMVKLSER IAGWTGKKPV
     LTVKDLGDSL AERWFDCKRA KEVLGWEPLV SIKDGLKEAA EESRRGKEGR
//